mAb806 binding to epidermal growth factor receptor: a computational study

scientific article published on 18 November 2014

mAb806 binding to epidermal growth factor receptor: a computational study is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/PROT.24714
P698PubMed publication ID25370927
P5875ResearchGate publication ID267812399

P50authorDavid P. LaneQ909289
P2093author name stringGloria Fuentes
Chandra S Verma
Srinivasaraghavan Kannan
Yao Zong Ng
P2860cites workAn allosteric mechanism for activation of the kinase domain of epidermal growth factor receptorQ24293598
EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerizationQ24296900
Crystal structure of the complex of human epidermal growth factor and receptor extracellular domainsQ24307661
Interaction of antibodies with ErbB receptor extracellular regionsQ37320814
Characterization of Glycosylation Sites of the Epidermal Growth Factor ReceptorQ37396323
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Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicityQ39908130
Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptorQ40568272
HER-2/neu and hTERT cryptic epitopes as novel targets for broad spectrum tumor immunotherapyQ40730426
Cryptic T-cell epitopes and their role in the pathogenesis of autoimmune diseasesQ41664274
Epitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional propertiesQ41966195
HIVgp120 activates autoreactive CD4-specific T cell responses by unveiling of hidden CD4 peptides during processingQ42942993
Structural basis for inhibition of the epidermal growth factor receptor by cetuximabQ45345151
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Electrostatics-defying interaction between arginine termini as a thermodynamic driving force in protein-protein interactionQ46489549
Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR geneQ48647863
Structural model of the mAb 806-EGFR complex using computational docking followed by computational and experimental mutagenesisQ51249291
Generalized born model with a simple smoothing functionQ52009475
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How can cryptic epitopes trigger autoimmunity?Q24678950
Comparison of simple potential functions for simulating liquid waterQ26778447
Structure of the extracellular region of HER2 alone and in complex with the Herceptin FabQ27640593
Antibodies specifically targeting a locally misfolded region of tumor associated EGFRQ27654155
Structures of adnectin/protein complexes reveal an expanded binding footprintQ27677197
Two potential therapeutic antibodies bind to a peptide segment of membrane-bound IgE in different conformationsQ27688964
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapyQ27824812
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VMD: visual molecular dynamicsQ27860554
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HADDOCK: a protein-protein docking approach based on biochemical or biophysical informationQ27860814
Ligand-induced, receptor-mediated dimerization and activation of EGF receptorQ28646134
Erlotinib in previously treated non-small-cell lung cancerQ29547546
Comparative protein structure modeling using ModellerQ29615142
HADDOCK versus HADDOCK: new features and performance of HADDOCK2.0 on the CAPRI targetsQ29615981
Anatomy of hot spots in protein interfacesQ29616238
EGF-ERBB signalling: towards the systems levelQ29619032
Steered molecular dynamics investigations of protein function.Q30328260
Long-timescale molecular dynamics simulations of protein structure and function.Q30376113
Binding pathway of retinal to bacterio-opsin: a prediction by molecular dynamics simulationsQ33907934
Molecular dynamics study of unbinding of the avidin-biotin complexQ33915230
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complexQ34314489
A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptorQ34470390
Functional dissection of the epidermal growth factor receptor epitopes targeted by panitumumab and cetuximab.Q34504860
Synergy between trastuzumab and pertuzumab for human epidermal growth factor 2 (Her2) from colocalization: an in silicobased mechanismQ35558065
Regulation of the catalytic activity of the EGF receptor.Q35597077
Is allostery an intrinsic property of all dynamic proteins?Q35894622
Epidermal growth factor receptor targeting in cancerQ36557269
The epidermal growth factor receptor pathway: a model for targeted therapyQ36603677
Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer.Q36710542
Architecture and membrane interactions of the EGF receptorQ36923502
Overcoming the inadequacies or limitations of experimental structures as drug targets by using computational modeling tools and molecular dynamics simulationsQ36931811
Principles of protein-protein interactions: what are the preferred ways for proteins to interact?Q37114752
Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growthQ37138521
Structure-based view of epidermal growth factor receptor regulationQ37197992
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)153-168
P577publication date2014-11-18
P1433published inProteinsQ7251514
P1476titlemAb806 binding to epidermal growth factor receptor: a computational study
P478volume83

Reverse relations

cites work (P2860)
Q38795554Role of N-glycosylation in EGFR ectodomain ligand binding
Q64231035Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket

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