Down-regulation of the amyloid protein precursor of Alzheimer's disease by antisense oligonucleotides reduces neuronal adhesion to specific substrata

scientific article published in October 1997

Down-regulation of the amyloid protein precursor of Alzheimer's disease by antisense oligonucleotides reduces neuronal adhesion to specific substrata is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0006-8993(97)00757-9
P698PubMed publication ID9372205

P50authorElizabeth J. CoulsonQ42526277
P2093author name stringBarrett GL
Bartlett PF
Beyreuther K
Masters CL
Storey E
P2860cites workIsolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursorQ24317632
Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's diseaseQ28236160
Integral membrane heparan sulfate proteoglycansQ28262453
Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extensionQ28513050
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein geneQ28586800
Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursorQ28588379
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid proteinQ29547803
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptorQ29618322
Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brainQ33688786
Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfateQ33845492
The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron developmentQ35578716
Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitroQ36235391
Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowthQ36317817
Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neuronsQ36382469
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's diseaseQ36415791
Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activityQ36415795
beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of lamininQ36636403
Alzheimer's disease amyloid precursor protein on the surface of cortical neurons in primary culture co-localizes with adhesion patch componentsQ36831631
Specificity of antisense oligonucleotides in vivoQ37145033
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transportQ37701379
Plasticity of sensory and motor maps in adult mammalsQ37716911
The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor geneQ38295633
A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowthQ38309410
Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.Q38362649
beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease.Q40384274
Extracellular matrix. 2: Role of extracellular matrix molecules and their receptors in the nervous system.Q40845499
Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein.Q41240734
Distribution of an APP homolog, APLP2, in the mouse olfactory system: a potential role for APLP2 in axogenesis.Q41292922
Transforming growth factor beta mediates increase of mature transmembrane amyloid precursor protein in microglial cellsQ41474645
The expression of amyloid beta protein precursor protects nerve cells from beta-amyloid and glutamate toxicity and alters their interaction with the extracellular matrixQ41509726
Role of amyloid precursor protein (APP): study with antisense transfection of human neuroblastoma cellsQ41630684
Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in cultureQ41656266
An antibody to beta amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell typesQ41687019
Beta amyloid precursor protein mediates neuronal cell-cell and cell-surface adhesionQ41709571
Expression of beta amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR.Q41746563
A heparan sulfate proteoglycan in developing avian axonal tractsQ42505779
A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesionQ42795680
Developmental and differential expression of beta amyloid protein precursor mRNAs in mouse brainQ44236384
Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts.Q45966280
A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitorsQ46046983
Gene inhibition using antisense oligodeoxynucleotidesQ46429559
Secreted forms of beta-amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neuronsQ48151610
Association and release of the amyloid protein precursor of Alzheimer's disease from chick brain extracellular matrixQ48418073
Laminin--developmental expression and role in axonal outgrowth in the peripheral nervous system of the chickQ48454102
The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowthQ48458288
Synapse formation occurs in association with the induction of long-term potentiation in two-year-old rat hippocampus in vitroQ48664500
The amyloid precursor protein of Alzheimer's disease is found on the surface of static but not activity motile portions of neuritesQ48913086
Developmental Regulation of Neural Response to FGF-1 and FGF-2 by Heparan Sulfate ProteoglycanQ52225676
Alzheimer's disease amyloid precursor protein is present in senile plaques and cerebrospinal fluid: immunohistochemical and biochemical characterization.Q53186800
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.Q53188216
Interaction between the zinc (II) and the heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP).Q53205067
APP-collagen interaction is mediated by a heparin bridge mechanism.Q53293826
Alzheimer's disease amyloid precursor protein (ApPP): proteolytic processing, secretases and βA4 amyloid productionQ58266260
Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor proteinQ67292492
Probing the function of novel genes in the nervous system: is antisense the answer?Q71544491
Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cellsQ71971007
Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent mannerQ72632596
Localization of a laminin-binding protein in brainQ72714432
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P1104number of pages9
P304page(s)72-80
P577publication date1997-10-01
P1433published inBrain ResearchQ4955782
P1476titleDown-regulation of the amyloid protein precursor of Alzheimer's disease by antisense oligonucleotides reduces neuronal adhesion to specific substrata
P478volume770

Reverse relations

cites work (P2860)
Q41737049A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis
Q24674865A novel mechanism for the regulation of amyloid precursor protein metabolism
Q39533342APP and APLP1 are degraded through autophagy in response to proteasome inhibition in neuronal cells.
Q34142269Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization
Q48723976Amyloid precursor protein expression in the rat hippocampal dentate gyrus modulates during memory consolidation
Q34731871Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance
Q48228409Amyloid precursor protein of Alzheimer's disease: evidence for a stable, full-length, trans-membrane pool in primary neuronal cultures
Q41913548Antisense inhibition at the beta-secretase-site of beta-amyloid precursor protein reduces cerebral amyloid and acetyl cholinesterase activity in Tg2576.
Q35098524Beta-amyloid and cholinergic neurons
Q26829183Curcuminoids and resveratrol as anti-Alzheimer agents
Q34976286Death and survival of neuronal cells exposed to Alzheimer's insults
Q37405228Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome
Q78693946Down-regulation of amyloid precursor protein by peptide nucleic acid oligomer in cultured rat primary neurons and astrocytes
Q38331415Drug delivery of antisense molecules to the brain for treatment of Alzheimer's disease and cerebral AIDS.
Q34592412Emerging multifunctional aspects of cellular serine proteinase inhibitors in tumor progression and tissue regeneration
Q40817592Expression of mutant amyloid precursor proteins decreases adhesion and delays differentiation of Hep-1 cells
Q34995120Presenilins and APP in neuritic and synaptic plasticity: implications for the pathogenesis of Alzheimer's disease
Q34284352Secretases as therapeutic targets for the treatment of Alzheimer's disease
Q53231417The amyloid beta-protein precursor of Alzheimer's disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons.
Q37845036The many substrates of presenilin/γ-secretase
Q33838961What the evolution of the amyloid protein precursor supergene family tells us about its function
Q24291602c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK

Search more.