A novel conformationally restricted protein kinase C inhibitor, Ro 31-8425, inhibits human neutrophil superoxide generation by soluble, particulate and post-receptor stimuli

scientific article published in November 1991

A novel conformationally restricted protein kinase C inhibitor, Ro 31-8425, inhibits human neutrophil superoxide generation by soluble, particulate and post-receptor stimuli is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/0014-5793(91)81178-B
P698PubMed publication ID1660001
P5875ResearchGate publication ID21495738

P50authorSandra OrchardQ47503082
P2093author name stringDavis PD
Elliott LH
Hill CH
Lawton G
Wilkinson SE
Wadsworth J
Dale MM
Kumar H
Muid RE
Twomey BM
P2860cites workStudies with protein kinase C inhibitors presently available cannot elucidate the role of protein kinase C in the activation of NADPH oxidase.Q53042404
The interleukin-2 T-cell system: a new cell growth model.Q55062562
Potent selective inhibitors of protein kinase CQ57005076
The role of protein kinase C in cell surface signal transduction and tumour promotionQ29618532
Calcium influx stimulates a second pathway for sustained diacylglycerol production in leukocytes activated by chemoattractantsQ33557357
K252a is a potent and selective inhibitor of phosphorylase kinaseQ34655234
K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinasesQ34684562
Control of biologically active interleukin 2 messenger RNA formation in induced human lymphocytes.Q36258532
Elaboration of toxic oxygen by-products by neutrophils in a model of immune complex diseaseQ40002259
Self-perpetuating mechanisms of immunoglobulin G aggregation in rheumatoid inflammationQ40921675
The effect of new potent selective inhibitors of protein kinase C on the neutrophil respiratory burstQ41201640
Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinaseQ42216028
Phospholipase D activation is functionally linked to superoxide generation in the human neutrophilQ42543312
The effect of putative protein kinase C inhibitors, K252a and staurosporine, on the human neutrophil respiratory burst activated by both receptor stimulation and post-receptor mechanismsQ42563267
Stimulation of phosphorylcholine turnover and diacylglycerol production in human polymorphonuclear leukocytes. Novel assay for phosphorylcholineQ42836468
The protein kinase C inhibitors H-7 and H-9 fail to inhibit human neutrophil activationQ46299642
Modulation of cellular processes by H7, a non-selective inhibitor of protein kinasesQ48791313
P433issue1-2
P407language of work or nameEnglishQ1860
P304page(s)169-172
P577publication date1991-11-01
P1433published inFEBS LettersQ1388051
P1476titleA novel conformationally restricted protein kinase C inhibitor, Ro 31-8425, inhibits human neutrophil superoxide generation by soluble, particulate and post-receptor stimuli
P478volume293

Reverse relations

cites work (P2860)
Q41408757A cell-based reporter assay for the identification of protein kinase C activators and inhibitors
Q33698833A novel protein kinase target for the lipid second messenger phosphatidic acid
Q27321219A small-molecule screen for enhanced homing of systemically infused cells
Q40896788Activation and tyrosine phosphorylation of protein kinase C delta in response to B cell antigen receptor stimulation
Q31140832Approaches to study posttranslational regulation of intermediate filament proteins.
Q41943052Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes
Q73149488Different sensitivities of neutrophil responses to a selective protein kinase C inhibitor Ro 31-8425; redundancy in signal transduction
Q72285870Effect of a selective protein kinase C inhibitor, Ro 31-8425, on Mac-1 expression and adhesion of human neutrophils
Q28365354Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H(2) receptors
Q28269137Fcgamma receptor signaling in phagocytes
Q36780383Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization
Q33744100Inhibition of development of Myxococcus xanthus by eukaryotic protein kinase inhibitors
Q42017361Inhibition of rabbit aortic smooth muscle cell proliferation by selective inhibitors of protein kinase C
Q51543526Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes.
Q43038640Participation of protein kinases in staurosporine-induced interleukin-6 production by rat peritoneal macrophages
Q46776698Pityriarubins, novel highly selective inhibitors of respiratory burst from cultures of the yeast Malassezia furfur: comparison with the bisindolylmaleimide arcyriarubin A.
Q28569384Prostaglandin E2 induces contraction of liver myofibroblasts by activating EP3 and FP prostanoid receptors
Q42122867Protein kinase C activity is not involved in N-formylmethionyl-leucyl-phenylalanine-induced phospholipase D activation in human neutrophils, but is essential for concomitant NADPH oxidase activation: studies with a staurosporine analogue with improv
Q43847513Protein kinase C increases 11beta-hydroxysteroid dehydrogenase oxidation and inhibits reduction in rat Leydig cells
Q72508371Protein kinase C is not a downstream effector of p21ras in activated T cells
Q38342490Regulation of clusterin gene expression by transforming growth factor beta
Q40900661Therapeutic potential of protein kinase C inhibitors
Q33574672mu-Opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD.

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