Biochemical evidence for the 5-HT agonist properties of PAT (8-hydroxy-2-(di-n-propylamino)tetralin) in the rat brain

scientific article published on May 4, 1984

Biochemical evidence for the 5-HT agonist properties of PAT (8-hydroxy-2-(di-n-propylamino)tetralin) in the rat brain is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/0014-2999(84)90002-5
P953full work available at URLhttps://api.elsevier.com/content/article/PII:0014299984900025?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:0014299984900025?httpAccept=text/xml
P698PubMed publication ID6203761

P2093author name stringC. Goetz
H. Gozlan
M. Hamon
S. Bourgoin
A. S. Horn
F. Artaud
M. D. Hall
P2860cites workProtein measurement with the Folin phenol reagentQ20900776
The role of intraneuronal 5-HT and of tryptophan hydroxylase activation in the control of 5-HT synthesis in rat brain slices incubated in K+-enriched mediumQ28291623
Effect of nerve activity on the in vivo release of [3H]serotonin continuously formed from l-[3H]tryptophan in the caudate nucleus of the catQ40229408
Solubilization of brain muscarinic, dopaminergic and serotonergic receptors: a critical analysisQ40338361
Autoreceptor-mediated inhibition of 3H-5-hydroxytryptamine release from rat brain cortex slices by analogues of 5-hydroxytryptamineQ42252300
Effect of guanine nucleotides on striatal dopamine receptorsQ44614204
Effects of some derivatives of 2-aminotetralin on dopamine-sensitive adenylate cyclase and on the binding of [3H]haloperidol to neuro-leptic receptors in the rat striatumQ44945527
A highly sensitive adenylate cyclase assayQ47871494
Dopamine receptor binding: specificity, localization and regulation by ions and guanyl nucleotidesQ48168538
Paradoxical decrease of brain 5-HT turnover by metergoline, a central 5-HT receptor blockerQ48190336
The effects of quipazine on 5-HT metabolism in the rat brainQ48375758
Effects of LSD on synthesis and release of 5-HT in rat brain slicesQ48564450
Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PATQ48738976
Evidence for common pharmacological properties of [3H]5-hydroxytryptamine binding sites, presynaptic 5-hydroxytryptamine autoreceptors in CNS and inhibitory presynaptic 5-hydroxytryptamine receptors on sympathetic nervesQ48742796
Pharmacological characterization of presynaptic alpha-adrenoceptors modulating [3H]noradrenaline and [3H]5-hydroxytryptamine release from slices of the hippocampus of the rat.Q48932837
The serotonin autoreceptor: antagonism by quipazineQ48950128
Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brainQ51231323
Effects of m-chlorophenylpiperazine on receptor binding and brain metabolism of monoamines in rats.Q53950653
8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonistQ70564470
Serotonin-receptor-mediated modulation of Ca2+-dependent 5-hydroxytryptamine release from neurones of the rat brain cortexQ70772189
Serotonin-sensitive adenylate cyclase and [3H]serotonin binding sites in the CNS of the rat--IQ71350772
Discrimination of multiple [3H]5-hydroxytryptamine binding sites by the neuroleptic spiperone in rat brainQ71482384
Substituted piperazines as central serotonin agonists: comparative specificity of the postsynaptic actions of quipazine and m-trifluoromethylphenylpiperazineQ72641839
Further evidence for negative feedback control of serotonin release in the central nervous systemQ72645228
8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition siteQ72789858
Are 5-HT receptors involved in the sprouting of serotoninergic terminals following neonatal 5,7-dihydroxytryptamine treatment in the rat?Q84268466
Alterations in central neurotransmitter receptor binding sites following estradiol implantation in female ratsQ84269018
P433issue3-4
P407language of work or nameEnglishQ1860
P921main subjectpharmacologyQ128406
P304page(s)263-276
P577publication date1984-05-01
1984-05-04
P1433published inEuropean Journal of PharmacologyQ1376712
P1476titleBiochemical evidence for the 5-HT agonist properties of PAT (8-hydroxy-2-(di-n-propylamino)tetralin) in the rat brain
P478volume100

Reverse relations

cites work (P2860)
Q429243953H-F13640, a novel, selective and high-efficacy serotonin 5-HT1A receptor agonist radioligand
Q481020625-Hydroxytryptamine inhibits cholinergic transmission through 5-HT1A receptor subtypes in rabbit vesical parasympathetic ganglia
Q484193948-OH-DPAT-induced hyperphagia: its neural basis and possible therapeutic relevance
Q344123728-OH-DPAT-induced mydriasis in mice: a pharmacological characterisation
Q724072998-[3H]hydroxy-2-(di-n-propylamino) tetralin binding sites in goldfish retina
Q48141533A neuronal nitric oxide synthase inhibitor 7-nitroindazole reduces the 5-HT1A receptor against 8-OH-DPAT-elicited hyperphagia in rats
Q41762851Agonist-induced glycogenolysis in rabbit retinal slices and cultures
Q48401265Allosteric inhibition as a model to explain flatter displacement curves in binding experiments: application to "heterogeneous" serotonin receptors
Q48704163Apparent absence of aging and gender effects on serotonin 1A receptors in human neocortex and hippocampus
Q48171324Behavioral, neuroendocrine and serotonergic consequences of single social defeat and repeated fluoxetine pretreatment in the Lewis rat strain.
Q41763990Binding of the novel serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin in normal and Alzheimer brain
Q48915226Changes in exploratory behaviour of hamsters following treatment with 8-hydroxy-2-(di-n-propylamino)tetralin
Q67904124Characterization of a Novel Serotonin Receptor Subtype (5-HTls) in Rat CNS: Interaction with a GTP Binding Protein
Q48427751Characterization of the 5-hydroxytryptamine receptor modulating the release of 5-[3H]hydroxytryptamine in slices of the human neocortex
Q58830771Communications
Q42527119Demonstration of an autoreceptor modulating the release of [3H]5-hydroxytryptamine from a synaptosomal-rich spinal cord tissue preparation
Q34558558Different effects on the responses of functional pre- and postsynaptic 5-HT1A receptors by repeated treatment of rats with the 5-HT1A receptor agonist 8-OH-DPAT
Q48340006Differentiation of pre- and post-synaptic high affinity serotonin receptor binding sites using physico-chemical parameters and modifying agents
Q48245997Dopamine D2 Receptor‐Mediated Regulation of Serotonin Extracellular Concentration in the Dorsal Raphe Nucleus of Freely Moving Rats
Q43903569Effect of antiepileptic and antimyoclonic drugs on serotonin receptors in vitro
Q67902289Effects of 5-HT-1A receptor agonists on CRF-induced behavior
Q48733732Effects of food deprivation on midbrain 5-HT1A autoreceptors in Lewis and SHR rats
Q42849006Evidence for depressant 5-HT1-like receptors on rat brainstem neurones
Q43900742Evidence that 5-HT1A receptors are involved in the adrenaline-releasing effects of 8-OH-DPAT in the conscious rat.
Q43701390Further characterization of 5-HT1A receptors in the goldfish retina: role of cyclic AMP in the regulation of the in vitro outgrowth of retinal explants
Q48339709GR 127935 and (+)-WAY 100135 do not affect TFMPP-induced inhibition of 5-HT synthesis in the midbrain and hippocampus of Wistar-Kyoto rats
Q42209864Identification of 5-hydroxytryptamine1A receptor proteins in bovine frontal cortex
Q48419772Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites
Q42483039In Vivo Brain Dialysis Study of the Somatodendritic Release of Serotonin in the Raphe Nuclei of the Rat: Effects of 8‐Hydroxy‐2‐(Di‐n‐Propylamino)tetralin
Q69453513Inhibition of noradrenaline release via presynaptic 5-HT1B receptors of the rat vena cava
Q42570966Involvement of 5-HT1A- and alpha 2-receptors in the decreased 5-hydroxytryptamine release and metabolism in rat suprachiasmatic nucleus after intravenous 8-hydroxy-2-(n-dipropylamino) tetralin
Q48574385Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat.
Q52219933Modification of 8-OH-DPAT effects on learning by manipulation of the assay conditions.
Q37828699Molecular studies of 5-HT receptors
Q48251635Neuropharmacological reassessment of the discriminative stimulus properties of d-lysergic acid diethylamide (LSD).
Q48423837Para-chlorophenylalanine prevents feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT).
Q39183732Pharmacological analysis of male rat sexual behavior
Q42204053Photoaffinity labelling and solubilization on the central 5-HT1A receptor binding site
Q35087781Positron emission tomography quantification of serotonin(1A) receptor binding in suicide attempters with major depressive disorder
Q24674187Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats
Q48445722Presynaptic serotonin receptor-mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock
Q68948009Rat brain serotonin: biochemical and functional evidence for a sex difference
Q69993412Receptor-mediated effects of serotonin and 5-methoxytryptamine on noradrenaline release in the rat vena cava and in the heart of the pithed rat
Q37407523Serotonin initiates and autoamplifies its own synthesis during mouse central nervous system development
Q42208613Serotonin receptor subtype mediation of the interoceptive discriminative stimuli induced by 5-methoxy-N,N-dimethyltryptamine
Q46952122Species differences in presynaptic serotonin autoreceptors: mainly 5-HT1B but possibly in addition 5-HT1D in the rat, 5-HT1D in the rabbit and guinea-pig brain cortex
Q52243743Structure-activity relationships of MDMA and related compounds: a new class of psychoactive drugs?
Q69062043The 5-HT 1A receptor agonist, 8-OH-DPAT, preferentially activates cell body 5-HT autoreceptors in rat brain in vivo
Q34099158The 5-HT1A receptor and the stimulus effects of LSD in the rat.
Q48306382The 5-HT1A receptor selective ligands, (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons
Q40618777The 5-Hydroxytryptamine(1A) Receptor Is Stably Palmitoylated, and Acylation Is Critical for Communication of Receptor with Gi Protein
Q38004415The central 5-HT1A receptors: pharmacological, biochemical, functional, and regulatory properties.
Q48419501The effects of a 5-HT1 receptor ligand isapirone (TVX Q 7821) on 5-HT synthesis and the behavioural effects of 5-HT agonists in mice and rats
Q42088389[(3)H]-8-OH-DPAT binding in the rat brain raphe area: involvement of 5-HT(1A) and non-5-HT(1A) receptors
Q42203427[3H]1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine: a selective radioligand for 5-HT1A receptors in rat brain
Q48485057[3H]8-hydroxy-2-(di-n-propylamino)tetralin binding to pre- and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain

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