Role of brain tissue localized purine metabolizing enzymes in the central nervous system delivery of anti-HIV agents 2'-beta-fluoro-2',3'-dideoxyinosine and 2'-beta-fluoro-2',3'-dideoxyadenosine in rats

scientific article published on June 1, 1997

Role of brain tissue localized purine metabolizing enzymes in the central nervous system delivery of anti-HIV agents 2'-beta-fluoro-2',3'-dideoxyinosine and 2'-beta-fluoro-2',3'-dideoxyadenosine in rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1023/A:1012110724604
P698PubMed publication ID9210198

P2093author name stringB. D. Anderson
M. E. Morgan
D. Singhal
P2860cites workUptake kinetics of 2',3'-dideoxyinosine into brain and cerebrospinal fluid of rats: intravenous infusion studiesQ49045512
Dose-dependent brain delivery of zidovudine through the use of a zidovudine chemical delivery systemQ71536639
Role of altered metabolism in dideoxynucleoside pharmacokinetics. Studies of 2'-beta-fluoro-2',3'-dideoxyinosine and 2'-beta-fluoro-2',3'-dideoxyadenosine in ratsQ71731685
A STUDY OF THE TISSUE DISTRIBUTION OF ADENOSINE DEAMINASE IN SIX MAMMAL SPECIESQ78342778
Molecular targets for AIDS therapyQ28323494
Potential anti-AIDS drugs. Lipophilic, adenosine deaminase-activated prodrugsQ28327907
Acid-stable 2'-fluoro purine dideoxynucleosides as active agents against HIVQ28329208
Incorporation of analog purine nucleosides into the formed elements of human blood: erythrocytes, platelets, and lymphocytesQ34063521
Metabolism of 2',3'-dideoxyinosine (ddI) in human bloodQ34402837
Central nervous system targeting of 2',3'-dideoxyinosine via adenosine deaminase-activated 6-halo-dideoxypurine prodrugsQ36757759
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Enhancement by 2'-deoxycoformycin of the 5'-phosphorylation and anti-human immunodeficiency virus activity of 2',3'-dideoxyadenosine and 2'-beta-fluoro-2',3'-dideoxyadenosine.Q41430419
2'-Fluoro-2',3'-dideoxyarabinosyladenine: a metabolically stable analogue of the antiretroviral agent 2',3'-dideoxyadenosineQ41739422
2',3'-Dideoxy-2'-fluoro-ara-A. An acid-stable purine nucleoside active against human immunodeficiency virus (HIV).Q42219490
Dideoxycytidine alone and in an alternating schedule with zidovudine in children with symptomatic human immunodeficiency virus infectionQ43514070
Effect of continuous intravenous infusion of zidovudine (AZT) in children with symptomatic HIV infectionQ44134576
Initial studies on the cellular pharmacology of 2',3'-dideoxyadenosine, an inhibitor of HTLV-III infectivityQ44304958
Dideoxyinosine in Children with Symptomatic Human Immunodeficiency Virus InfectionQ45860738
Adenosine metabolism in microvessels from heart and brainQ48417388
Brain, Blood, and Cerebrospinal Fluid Distribution of a Zidovudine Chemical Delivery System in RabbitsQ48663341
Probenecid enhances central nervous system uptake of 2',3'-dideoxyinosine by inhibiting cerebrospinal fluid efflux.Q48712713
Localization of purine metabolizing enzymes in bovine brain microvessel endothelial cells: an enzymatic blood-brain barrier for dideoxynucleosides?Q48846114
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectbrain tissueQ11850260
P304page(s)786-792
P577publication date1997-06-01
P1433published inPharmaceutical ResearchQ7180737
P1476titleRole of brain tissue localized purine metabolizing enzymes in the central nervous system delivery of anti-HIV agents 2'-beta-fluoro-2',3'-dideoxyinosine and 2'-beta-fluoro-2',3'-dideoxyadenosine in rats
P478volume14

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cites work (P2860)
Q33933498Development and optimization of anti-HIV nucleoside analogs and prodrugs: A review of their cellular pharmacology, structure-activity relationships and pharmacokinetics
Q73850558Investigation of distribution, transport and uptake of anti-HIV drugs to the central nervous system
Q74511156Optimization of the local inhibition of intestinal adenosine deaminase (ADA) by erythro-9-(2-hydroxy-3-nonyl)adenine: enhanced oral delivery of an ADA-activated prodrug for anti-HIV therapy
Q37193593Progress in drug delivery to the central nervous system by the prodrug approach.

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