A functional role for complex gangliosides: motor deficits in GM2/GD2 synthase knockout mice

scientific article published in December 2000

A functional role for complex gangliosides: motor deficits in GM2/GD2 synthase knockout mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1006/EXNR.2000.7504
P698PubMed publication ID11085888
P5875ResearchGate publication ID222561758

P50authorRandy J. NelsonQ37371556
Silvana ChiavegattoQ42755893
Ronald L SchnaarQ42852048
P2093author name stringSun J
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectknockout mouseQ1364740
P304page(s)227-234
P577publication date2000-12-01
P1433published inExperimental NeurologyQ5421127
P1476titleA functional role for complex gangliosides: motor deficits in GM2/GD2 synthase knockout mice
P478volume166

Reverse relations

cites work (P2860)
Q24602345Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes
Q84739890Accelerated clinical disease and pathology in mucopolysaccharidosis type IIIB and GalNAc transferase double knockout mice
Q44175484Anti-ganglioside antibodies bind with enhanced affinity to gangliosides containing very long chain fatty acids
Q34157779Beta1,4-N-acetylgalactosaminyltransferase--GM2/GD2 synthase: a key enzyme to control the synthesis of brain-enriched complex gangliosides
Q35153204Biosynthesis and degradation of mammalian glycosphingolipids
Q34346493Brain gangliosides: functional ligands for myelin stability and the control of nerve regeneration
Q100454969Caveolin 1 is required for axonal outgrowth of motor neurons and affects Xenopus neuromuscular development
Q44102376Complex gangliosides at the neuromuscular junction are membrane receptors for autoantibodies and botulinum neurotoxin but redundant for normal synaptic function.
Q48698146Conditional LoxP-flanked glucosylceramide synthase allele controlling glycosphingolipid synthesis
Q48466996Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans
Q50667993Deficits in cognitive function and hippocampal plasticity in GM2/GD2 synthase knockout mice.
Q47154575Disease-modifying effects of ganglioside GM1 in Huntington's disease models.
Q56356639Diseases of ganglioside biosynthesis: An expanding group of congenital disorders of glycosylation
Q38587703Dissecting the Role of Anti-ganglioside Antibodies in Guillain-Barré Syndrome: an Animal Model Approach.
Q47070636Drosophila egghead encodes a beta 1,4-mannosyltransferase predicted to form the immediate precursor glycosphingolipid substrate for brainiac
Q39229360Effect of ganglioside GM3 synthase gene knockout on the glycoprotein N-glycan profile of mouse embryonic fibroblast
Q46818702Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1.
Q51040506First total synthesis of ganglioside DSG-A possessing neuritogenic activity.
Q35186924Functional role of a specific ganglioside in neuronal migration and neurite outgrowth
Q37494316Functional roles of gangliosides in neurodevelopment: an overview of recent advances
Q30383741Ganglioside GM3 is essential for the structural integrity and function of cochlear hair cells
Q49829715Ganglioside Metabolism and Parkinson's Disease
Q35361488Ganglioside biochemistry
Q34955771Ganglioside function in calcium homeostasis and signaling
Q38352766Ganglioside/calmodulin kinase II signal inducing cdc42-mediated neuronal actin reorganization
Q56772126Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibers
Q38853822Gangliosides of the Vertebrate Nervous System
Q37027396Glycan antagonists and inhibitors: a fount for drug discovery
Q35153220Glycosphingolipid functions: insights from engineered mouse models
Q38155963Glycosphingolipids: synthesis and functions
Q38241672Human genetic disorders of sphingolipid biosynthesis
Q39726453Impaired ganglioside metabolism in Huntington's disease and neuroprotective role of GM1.
Q33334765Impaired hypoglossal nerve regeneration in mutant mice lacking complex gangliosides: down-regulation of neurotrophic factors and receptors as possible mechanisms
Q38859739Increasing acetyl-CoA metabolism attenuates injury and alters spinal cord lipid content in mice subjected to experimental autoimmune encephalomyelitis
Q33863886Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions
Q35931476It's a lipid's world: bioactive lipid metabolism and signaling in neural stem cell differentiation
Q90379387Lipids in the Physiopathology of Hereditary Spastic Paraplegias
Q35161290Mice lacking major brain gangliosides develop parkinsonism
Q35751923Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice.
Q33943783Myelin-associated glycoprotein and its axonal receptors
Q64120650Neuronal Signaling by Thy-1 in Nanodomains With Specific Ganglioside Composition: Shall We Open the Door to a New Complexity?
Q37479514Neuronal expression of GalNAc transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice.
Q48492427Neuroplastin expression in the hippocampus of mice lacking complex gangliosides
Q58555785Parkinsonian GM2 synthase knockout mice lacking mature gangliosides develop urinary dysfunction and neurogenic bladder
Q38218040Pathogenic role of ganglioside metabolism in neurodegenerative diseases
Q37535345Pathophysiological actions of neuropathy-related anti-ganglioside antibodies at the neuromuscular junction
Q37648392Physiological Exploration of the Long Term Evolutionary Selection against Expression of N-Glycolylneuraminic Acid in the Brain
Q26995291Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration
Q35774811Sialylation regulates brain structure and function
Q34577669Simplifying complexity: genetically resculpting glycosphingolipid synthesis pathways in mice to reveal function
Q93169003Sphingolipid dyshomeostasis in the brain of the mouse model of mucopolysaccharidosis type IIIA
Q39342245Sphingolipids: membrane microdomains in brain development, function and neurological diseases.
Q33453583Structural characterization of monosialo-, disialo- and trisialo-gangliosides by negative ion AP-MALDI-QIT-TOF mass spectrometry with MS(n) switching
Q37936732Structures, biosynthesis, and functions of gangliosides--an overview
Q45130172Susceptibility of cerebellar granule neurons from GM2/GD2 synthase-null mice to apoptosis induced by glutamate excitotoxicity and elevated KCl: rescue by GM1 and LIGA20.
Q38900943TALEN mediated targeted editing of GM2/GD2-synthase gene modulates anchorage independent growth by reducing anoikis resistance in mouse tumor cells
Q47144233The Enigmatic Role of GBA2 in Controlling Locomotor Function
Q37152815The chemical neurobiology of carbohydrates
Q41249640The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice
Q35949413The mdx Mutation in the 129/Sv Background Results in a Milder Phenotype: Transcriptome Comparative Analysis Searching for the Protective Factors
Q51722538The regulation of ER export and Golgi retention of ST3Gal5 (GM3/GM4 synthase) and B4GalNAcT1 (GM2/GD2/GA2 synthase) by arginine/lysine-based motif adjacent to the transmembrane domain.
Q38501568The role of gangliosides in neurodevelopment.
Q48639806Therapeutic effects of stem cells and substrate reduction in juvenile Sandhoff mice

Search more.