Flupirtine reduces functional deficits and neuronal damage after global ischemia in rats

scientific article published in April 1997

Flupirtine reduces functional deficits and neuronal damage after global ischemia in rats is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0006-8993(97)00096-6
P698PubMed publication ID9134985

P2093author name stringSchwarz M
Pergande G
Block F
P2860cites workPlace navigation impaired in rats with hippocampal lesionsQ29547869
Temporal profile of neuronal damage in a model of transient forebrain ischemiaQ34278838
Selective vulnerability of the hippocampus in brain ischemiaQ36501847
Flupirtine increases the levels of glutathione and Bc1-2 in hNT (human Ntera/D1) neurons: mode of action of the drug-mediated anti-apoptotic effectQ41145481
Neuronal degeneration in hippocampus and cerebellum of mutant spastic Han-Wistar ratsQ42476100
The N-methyl-D-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbilsQ43460736
Protection by NMDA antagonists against selective cell loss following transient ischaemiaQ43530761
Global ischaemia: hippocampal pathology and spatial deficits in the water maze.Q48120828
Depression by flupirtine, a novel analgesic agent, of motor and sensory responses of the nociceptive system in the rat spinal cordQ48184212
The antioxidant LY231617 reduces global ischemic neuronal injury in ratsQ48290608
Quinolinic acid lesion of the striatum induces impairment in spatial learning and motor performance in ratsQ48347045
The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the ratQ48545756
Spatial learning is affected by transient occlusion of common carotid arteries (2VO): comparison of behavioural and histopathological changes after '2VO' and 'four-vessel-occlusion' in ratsQ48759117
Protection against ischemia-induced neuronal damage by the alpha 2-adrenoceptor antagonist idazoxan: influence of time of administration and possible mechanisms of actionQ48874352
Pretreatment but not posttreatment with GYKI 52466 reduces functional deficits and neuronal damage after global ischemia in ratsQ48951360
Memantine reduces functional and morphological consequences induced by global ischemia in ratsQ48987990
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemiaQ49105194
Flupirtine depresses nociceptive activity evoked in rat thalamus.Q51769819
Posttreatment with EPC-K1, an inhibitor of lipid peroxidation and of phospholipase A2 activity, reduces functional deficits after global ischemia in ratsQ52055278
The antioxidant LY 231617 ameliorates functional and morphological sequelae induced by global ischemia in rats.Q52205394
Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia.Q52209617
S-emopamil ameliorates ischemic brain damage in rats: histological and behavioural approaches.Q52243195
Role for gamma-aminobutyric acid in selective vulnerability in gerbilsQ69950543
GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbilsQ70494137
MK-801 (dizocilpine) protects the brain from repeated normothermic global ischemic insults in the ratQ70501475
Flupirtine protects neurons against excitotoxic or ischemic damage and inhibits the increase in cytosolic Ca2+ concentrationQ71377073
Flupirtine protects against ischaemic retinal dysfunction in ratsQ72110358
Immunohistochemical evidence for flupirtine acting as an antagonist on theN-methyl-d-aspartate and homocysteic acid-induced release of GABA in the rabbit retinaQ72111867
The triaminopyridine flupirtine prevents cell death in rat cortical cells induced by N-methyl-D-aspartate and gp120 of HIV-1Q72130473
N-methyl-D-aspartate (NMDA)-mediated muscle relaxant action of flupirtine in ratsQ72498080
Cerebroprotective effect of BW619C89 after focal or global cerebral ischaemia in the ratQ72660431
P433issue1-2
P407language of work or nameEnglishQ1860
P304page(s)279-284
P577publication date1997-04-01
P1433published inBrain ResearchQ4955782
P1476titleFlupirtine reduces functional deficits and neuronal damage after global ischemia in rats
P478volume754

Reverse relations

cites work (P2860)
Q48223080Ameliorative effects of a neuroprotective agent, T-817MA, on place learning deficits induced by continuous infusion of amyloid-beta peptide (1-40) in rats
Q48344766Antioxidant properties of the triaminopyridine, flupirtine
Q42549147Antiparkinsonian and other motor effects of flupirtine alone and in combination with dopaminergic drugs
Q40842227Association of increased bcl-2 expression with rescue from tumor necrosis factor-alpha-induced cell death in the oligodendrocyte cell line OLN-93.
Q60952978Brain Distribution and Metabolism of Flupirtine, a Nonopioid Analgesic Drug with Antiseizure Effects, in Neonatal Rats
Q57816829Disease Modification in Multiple Sclerosis by Flupirtine-Results of a Randomized Placebo Controlled Phase II Trial
Q92376694Effects of a potassium channel opener on brain injury and neurologic outcomes in an animal model of neonatal hypoxic-ischemic injury
Q74317079Flupirtine and retigabine prevent L-glutamate toxicity in rat pheochromocytoma PC 12 cells
Q36943102Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis
Q41724627Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist
Q34322776Flupirtine, a re-discovered drug, revisited
Q33643194Global ischemia and behavioural deficits
Q54546730Hericium erinaceus suppresses LPS-induced pro-inflammation gene activation in RAW264.7 macrophages.
Q34038310Novel approaches in diagnosis and therapy of Creutzfeldt-Jakob disease
Q34747314Pharmacological intervention in age-associated brain disorders by Flupirtine: Alzheimer's and prion diseases
Q48424753Piperphentonamine (PPTA) attenuated cerebral ischemia-induced memory deficits via neuroprotection associated with anti-apoptotic activity
Q44287259Propofol post-conditioning induced long-term neuroprotection and reduced internalization of AMPAR GluR2 subunit in a rat model of focal cerebral ischemia/reperfusion
Q35092261Prospects for antiapoptotic drug therapy of neurodegenerative diseases
Q44650194Protective effects of methanol extract of Acori graminei rhizoma and Uncariae Ramulus et Uncus on ischemia-induced neuronal death and cognitive impairments in the rat
Q35872543The Effects of the KCNQ Openers Retigabine and Flupirtine on Myotonia in Mammalian Skeletal Muscle Induced by a Chloride Channel Blocker
Q41724639The b-wave of the electroretinogram as an index of retinal ischemia
Q42269178The indirect NMDAR inhibitor flupirtine induces sustained post-ischemic recovery, neuroprotection and angioneurogenesis.
Q79760113The neuroprotectant properties of glutamate antagonists and antiglutamatergic drugs
Q41860460The neuroprotective effect of methanol extract of gagamjungjihwan and fructus euodiae on ischemia-induced neuronal and cognitive impairment in the rat

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