Certain secondary antiepileptic drugs can rescue hippocampal injury following a critical growth period despite poor anticonvulsant activity and cognitive deficits

scientific article published on 5 October 2013

Certain secondary antiepileptic drugs can rescue hippocampal injury following a critical growth period despite poor anticonvulsant activity and cognitive deficits is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.YEBEH.2013.08.019
P698PubMed publication ID24103817

P2093author name stringHenry Hong
Linda K Friedman
Eiris Fahim
Karnika Kapoor
Lisa R Halbsgut
P2860cites workAntiepileptic drugs and apoptotic neurodegeneration in the developing brainQ24538604
Pattern of antiepileptic drug-induced cell death in limbic regions of the neonatal rat brainQ24632453
The neurobiology of antiepileptic drugsQ28267900
Effects of neonatal antiepileptic drug exposure on cognitive, emotional, and motor function in adult ratsQ30457770
Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of actionQ33632141
Management of epilepsy in adolescents and adults.Q34079108
Selection of antiepileptic drug polytherapy based on mechanisms of action: the evidence reviewedQ34082054
Lamotrigine reduces spontaneous and evoked GABAA receptor-mediated synaptic transmission in the basolateral amygdala: implications for its effects in seizure and affective disordersQ34123860
Topiramate-induced weight loss: a review.Q34193642
The mechanisms of action of commonly used antiepileptic drugsQ34305846
The new generation of GABA enhancers. Potential in the treatment of epilepsyQ34320951
Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapyQ34652321
The epidemiology of epilepsy in Rochester, Minnesota, 1935 through 1967Q34726303
Current limitations of antiepileptic drug therapy: a conference review.Q35063200
Short term outcomes of topiramate monotherapy as a first-line treatment in newly diagnosed West syndromeQ35649274
Behavioral and psychiatric adverse events associated with antiepileptic drugs commonly used in pediatric patientsQ35939591
Carbamazepine induction of apoptosis in cultured cerebellar neurons: effects of N-methyl-D-aspartate, aurintricarboxylic acid and cycloheximideQ36808939
Triggers of apoptosis in the immature brain.Q37420979
Epidemiology, classification, natural history, and genetics of epilepsyQ37597020
EEG diagnoses of neonatal seizures: clinical correlations and outcome.Q38517514
Outcome in neonates with convulsions treated in an intensive care unitQ38522159
Status epilepticus in children: aetiology, treatment, and outcome.Q40645294
A pharmacological and clinical review on topiramate, a new antiepileptic drugQ41571690
The susceptibility of rats to pilocarpine-induced seizures is age-dependentQ42215641
Effects of combined lamotrigine and valproate on basal and stimulated extracellular amino acids and monoamines in the hippocampus of freely moving ratsQ42473160
Neurodevelopmental impact of antiepileptic drugs and seizures in the immature brainQ42519629
Topiramate pharmacokinetics in infantsQ42603610
Lack of resveratrol neuroprotection in developing rats treated with kainic acidQ42714225
Glutamatergic and morphological alterations associated with early life seizure‐induced preconditioning in young ratsQ42836654
Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat.Q43716931
Synergistic interaction between valproate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice.Q44189175
Effect of topiramate following recurrent and prolonged seizures during early developmentQ44193568
Suppression of hippocampal neurogenesis is associated with developmental stage, number of perinatal seizure episodes, and glucocorticosteroid levelQ44668508
Effect of lamotrigine treatment on epileptogenesis: an experimental study in rat.Q44878785
Therapeutic doses of topiramate are not toxic to the developing rat brainQ44897078
Comparison of changes in the EEG of freely moving rats induced by enciprazine, buspirone and diazepamQ45825008
Topiramate reduces excitability in the basolateral amygdala by selectively inhibiting GluK1 (GluR5) kainate receptors on interneurons and positively modulating GABAA receptors on principal neurons.Q46024705
Effect of topiramate on cognitive function and activity level following neonatal seizuresQ46476285
Perinatal seizures preferentially protect CA1 neurons from seizure-induced damage in prepubescent ratsQ46821923
NR1 knockdown reveals CA1 injury during a developmental period of high seizure susceptibility despite reduced seizure activityQ46902597
Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsyQ46954553
Valproate selectively reduces EEG activity in anterior parts of the cortex in patients with idiopathic generalized epilepsy. A low resolution electromagnetic tomography (LORETA) studyQ48108458
Effects of the conventional anticonvulsants, phenytoin, carbamazepine, and valproic acid, on sodium-potassium-adenosine triphosphatase in acute ischemic brainQ48110459
Phenytoin- and carbamazepine-resistant spontaneous bursting in rat entorhinal cortex is blocked by retigabine in vitroQ48223995
PNU-151774E protects against kainate-induced status epilepticus and hippocampal lesions in the rat.Q48341596
GluR2 hippocampal knockdown reveals developmental regulation of epileptogenicity and neurodegenerationQ48363357
Cellular and molecular actions of lamotrigine: Possible mechanisms of efficacy in bipolar disorderQ48371331
The pathological basis of temporal lobe epilepsy in childhoodQ48400510
Effects of morphine on the differentiation and survival of developing pyramidal neurons during the brain growth spurtQ48424553
Voltage-activated calcium channels: targets of antiepileptic drug therapy?Q48473729
Kainic acid seizures in the developing brain: status epilepticus and spontaneous recurrent seizuresQ48526585
Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure thresholdQ48617665
Lamotrigine reduces voltage-gated sodium currents in rat central neurons in cultureQ48713682
Age-dependent cognitive and behavioral deficits after kainic acid seizuresQ48805284
Phenytoin neurotoxicity in developing mouse cerebellum in tissue cultureQ48925144
Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channelsQ49160604
Prediction of outcome based on clinical seizure type in newborn infants.Q51956034
Outcome after febrile status epilepticus.Q52203968
Long-term behavioral deficits following pilocarpine seizures in immature rats.Q52212860
Prognostic value of the electroencephalogram in term and preterm infants following neonatal seizures.Q54025261
AChE-stained horizontal sections of the rat brain in stereotaxic coordinatesQ58592230
Age-dependent changes in long-term seizure susceptibility and behavior after hypoxia in ratsQ67602575
Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: I. Anticonvulsant profile in mice and ratsQ69616967
Lamotrigine vs. phenytoin for treatment of status epilepticus: comparison in an experimental modelQ71519194
A Reliable and Sensitive Method to Localize Terminal Degeneration and Lysosomes in the Central Nervous SystemQ72627953
P433issue3
P304page(s)466-477
P577publication date2013-10-05
P1433published inEpilepsy BehaviorQ15746410
P1476titleCertain secondary antiepileptic drugs can rescue hippocampal injury following a critical growth period despite poor anticonvulsant activity and cognitive deficits
P478volume29

Reverse relations

cites work (P2860)
Q39298772Effect of lamotrigine on epilepsy-induced cognitive impairment and hippocampal neuronal apoptosis in pentylenetetrazole-kindled animal model
Q48193624Effects of mood-stabilizing drugs on dendritic outgrowth and synaptic protein levels in primary hippocampal neurons
Q53625048Neurodevelopmental Effects of Antiepileptic Drugs.
Q35198051Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture
Q35584573Short-term use of antiepileptic drugs is neurotoxic to the immature brain
Q38564727Third International Congress on Epilepsy, Brain, and Mind: Part 2.

Search more.