Physician-initiated clinical study of limb ulcers treated with a functional peptide, SR-0379: from discovery to a randomized, double-blind, placebo-controlled trial.

scientific article published on 13 February 2018

Physician-initiated clinical study of limb ulcers treated with a functional peptide, SR-0379: from discovery to a randomized, double-blind, placebo-controlled trial. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1100901771
P356DOI10.1038/S41514-018-0021-7
P932PMC publication ID5809414
P698PubMed publication ID29449960

P50authorHironori NakagamiQ30505241
Hiromi RakugiQ35703947
Misa HayashiQ87800983
Eiji KiyoharaQ87800987
P2093author name stringKen Sugimoto
Ayumi Nakamura
Ichiro Katayama
Minoru Takemoto
Tamotsu Ebihara
Koutaro Yokote
Hiroshi Ando
Takahiro Ishikawa
Yoichi Takami
Hideki Hanaoka
Masaya Koshizaka
Yasushi Takeya
Mitsunori Nishikawa
Taku Fujimoto
Koichi Yamamoto
Toshifumi Yamaoka
Yuta Terabe
Xiang Jing Yao
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The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 and ERK MAPK activation in primary human keratinocytesQ28262941
Novel anti-microbial peptide SR-0379 accelerates wound healing via the PI3 kinase/Akt/mTOR pathwayQ28541612
Positional cloning of the Werner's syndrome geneQ29618393
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An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.Q34534186
Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers. A phase III randomized placebo-controlled double-blind studyQ34747226
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PR39, a peptide regulator of angiogenesisQ73308219
Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trialQ73435807
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Physician-initiated first-in-human clinical study using a novel angiogenic peptide, AG30/5C, for patients with severe limb ulcersQ40219195
Guar gum as a new antimicrobial peptide delivery system against diabetic foot ulcers Staphylococcus aureus isolates.Q40585339
IWGDF guidance on the diagnosis and management of foot infections in persons with diabetesQ40991248
Treatment with LL-37 is safe and effective in enhancing healing of hard-to-heal venous leg ulcers: a randomized, placebo-controlled clinical trialQ42672939
APD2: the updated antimicrobial peptide database and its application in peptide designQ43122430
Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settingsQ44053817
Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan creamQ46260034
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P921main subjectplaceboQ269829
P304page(s)2
P577publication date2018-02-13
P1433published inNPJ aging and mechanisms of diseaseQ27727292
P1476titlePhysician-initiated clinical study of limb ulcers treated with a functional peptide, SR-0379: from discovery to a randomized, double-blind, placebo-controlled trial
P478volume4

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