The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition.

scientific article published on 21 December 2017

The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/IMCB.1018
P698PubMed publication ID29359407

P50authorAchim SchlapbachQ56168026
Thomas CalzasciaQ56640562
Catherine H RegnierQ57445006
P2093author name stringAdeline Unterreiner
Claire Malinverni
Frédéric Bornancin
Martin Renatus
Maureen Bardet
José M Carballido
Andreas Katopodis
Jiri Kovarik
Jean Quancard
Guido Bold
Daniel Kaiser
Martin A Schneider
Yeter Kolb
Corinne Vedrine
Carole Pissot-Soldermann
Oliver Simic
Anton Glück
Danielle Boesch
Frédérique Lafossas
P2860cites workThe common γ-chain cytokine receptor: tricks-and-treats for T cells.Q38607461
From basic apoptosis discoveries to advanced selective BCL-2 family inhibitorsQ39139792
The protease activity of the paracaspase MALT1 is controlled by monoubiquitination.Q39193083
Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.Q39226671
Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signalsQ40383554
Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammationQ41240873
Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammationQ41629410
Conditional IL-2 Gene Deletion: Consequences for T Cell ProliferationQ42155875
Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivoQ43687301
MALT1/paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-kappaB activationQ44750362
Critical role of TNF receptor type-2 (p75) as a costimulator for IL-2 induction and T cell survival: a functional link to CD28.Q45071243
The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.Q45985299
MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signalingQ48103382
The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling.Q52878989
MALT1 Protease Activity Controls the Expression of Inflammatory Genes in Keratinocytes upon Zymosan Stimulation.Q53209564
Zinc-binding metallothioneins are key modulators of IL-4 production by basophils.Q53572805
Staphylococcal enterotoxinsQ56679620
T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20Q24307779
Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signalingQ24619604
The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and PerspectiveQ26766916
The paracaspase MALT1: biological function and potential for therapeutic inhibitionQ26778357
Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspaseQ27685382
Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct MechanismsQ28116067
Differential Requirement for Malt1 in T and B Cell Antigen Receptor SignalingQ28505229
Regulation of NF-κB-Dependent Lymphocyte Activation and Development by ParacaspaseQ28591729
Sensitivity of metallothionein-null mice to LPS/D-galactosamine-induced lethalityQ31855339
Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2.Q33809396
T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1.Q34174201
Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.Q34211312
Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activationQ34346617
MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytesQ34432953
Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiationQ34441762
The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signallingQ34500164
CD28-mediated co-stimulation: a quantitative support for TCR signallingQ34543577
The proteolytic activity of the paracaspase MALT1 is key in T cell activationQ34748769
Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.Q34806889
The c-Rel Transcription Factor in Development and DiseaseQ35556506
Dendritic-cell control of pathogen-driven T-cell polarizationQ35597117
CARMA1, BCL-10 and MALT1 in lymphocyte development and activation.Q35762426
Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 ActivationQ36239551
Functions of BCL-X L at the Interface between Cell Death and MetabolismQ36702748
Noncanonical NF-κB signaling is limited by classical NF-κB activityQ37651821
MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivoQ37699271
Expression, biological activities and mechanisms of action of A20 (TNFAIP3).Q37769759
From MALT lymphoma to the CBM signalosome: three decades of discoveryQ37900457
The three CARMA sisters: so different, so similar: a portrait of the three CARMA proteins and their involvement in human disorders.Q38174486
P433issue1
P304page(s)81-99
P577publication date2017-12-21
P1433published inImmunology & Cell BiologyQ13731918
P1476titleThe T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition
P478volume96

Reverse relations

cites work (P2860)
Q91259871An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient
Q64087351Germinal center-derived lymphomas: The darkest side of humoral immunity
Q64983436Holding All the CARDs: How MALT1 Controls CARMA/CARD-Dependent Signaling.
Q55265317Impaired Control of Epstein-Barr Virus Infection in B-Cell Expansion with NF-κB and T-Cell Anergy Disease.
Q59353657Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice
Q93047664MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner
Q92669067MALT1 is a critical mediator of PAR1-driven NF-κB activation and metastasis in multiple tumor types
Q60924644Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function
Q57048861Molecular architecture and regulation of BCL10-MALT1 filaments
Q54247368NF-κB Activation in Lymphoid Malignancies: Genetics, Signaling, and Targeted Therapy.
Q95271987Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology
Q89138330Pharmacological inhibition of MALT1 protease activity suppresses endothelial activation via enhancing MCPIP1 expression
Q57072726The CBM-opathies-A Rapidly Expanding Spectrum of Human Inborn Errors of Immunity Caused by Mutations in the CARD11-BCL10-MALT1 Complex

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