Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice

scholarly article by E Kip et al published 29 August 2018 in Journal of Virology

Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.00720-18
P932PMC publication ID6206481
P698PubMed publication ID30158289

P50authorJens StaalQ37834573
Steven Van GuchtQ87609328
P2093author name stringR Beyaert
M Baens
M Romano
C Libert
M Kalai
A Hamouda
K Lemeire
L Verstrepen
V Suin
E Kip
H G Tima
P2860cites workEstimating the global burden of endemic canine rabiesQ21090117
Ambivalent role of the innate immune response in rabies virus pathogenesisQ24300579
Transmission dynamics and prospects for the elimination of canine rabiesQ27331839
Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspaseQ27685382
5'-Triphosphate RNA is the ligand for RIG-IQ28131726
Differential Requirement for Malt1 in T and B Cell Antigen Receptor SignalingQ28505229
Regulation of NF-κB-Dependent Lymphocyte Activation and Development by ParacaspaseQ28591729
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitisQ29615108
RabiesQ31165356
Inducible nitric oxide synthase inhibition delays death of rabies virus-infected miceQ32091319
Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis.Q33958556
Attenuated rabies virus activates, while pathogenic rabies virus evades, the host innate immune responses in the central nervous systemQ33984263
T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1.Q34174201
Local nitric oxide production in viral and autoimmune diseases of the central nervous systemQ34209628
Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.Q34211312
Alzheimer's disease, inflammation and non-steroidal anti-inflammatory drugsQ34297166
Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activationQ34346617
Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiationQ34441762
Microglia in human immunodeficiency virus-associated neurodegeneration.Q34963796
Immune responses to RNA-virus infections of the CNS.Q35140815
NF-κB signaling pathways regulated by CARMA family of scaffold proteinsQ35347919
Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptorQ35546855
Neuronal dysfunction and death in rabies virus infectionQ36086332
In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseasesQ36214276
Structural abnormalities in neurons are sufficient to explain the clinical disease and fatal outcome of experimental rabies in yellow fluorescent protein-expressing transgenic miceQ36424030
Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse BrainQ36788361
Invasion of the peripheral nervous systems of adult mice by the CVS strain of rabies virus and its avirulent derivative AvO1Q36830073
Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignanciesQ36988095
Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies.Q37097294
Immune evasion, a critical strategy for rabies virus.Q37218920
Rabies virus stimulates nitric oxide production and CXC chemokine ligand 10 expression in macrophages through activation of extracellular signal-regulated kinases 1 and 2.Q37348438
The roles of chemokines in rabies virus infection: overexpression may not always be beneficialQ37410626
Lyssaviruses and rabies: current conundrums, concerns, contradictions and controversiesQ37664750
Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease.Q37682941
MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivoQ37699271
Evasive strategies in rabies virus infection.Q37877950
Rabies virus clearance from the central nervous system.Q37877951
From MALT lymphoma to the CBM signalosome: three decades of discoveryQ37900457
The AIDS dementia complex and HIV-1 brain infection: a pathogenetic model of virus-immune interactionQ37915262
MALT1--a universal soldier: multiple strategies to ensure NF-κB activation and target gene expressionQ38495157
Targeting MALT1 Proteolytic Activity in Immunity, Inflammation and Disease: Good or Bad?Q38703574
CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral InfectionQ38788570
Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.Q39226671
The type I interferon response bridles rabies virus infection and reduces pathogenicityQ39497376
Collaboration of antibody and inflammation in clearance of rabies virus from the central nervous system.Q39578252
Failure to thrive, wasting syndrome, and immunodeficiency in rabies: a hypophyseal/hypothalamic/thymic axis effect of rabies virusQ39618245
The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA.Q40211782
Human rabies: clinical aspects, pathogenesis, and potential therapy.Q40595402
Correlation of inducible nitric oxide synthase (iNOS) inhibition with TNF-α, caspase-1, FasL and TLR-3 in pathogenesis of rabies in mouse modelQ40862930
The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cellsQ41522425
Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritisQ41717303
Microglia, seen from the CX3CR1 angleQ43226619
Pathogenesis of experimental rabies in mice: an immunohistochemical studyQ43460491
Microglial activation and recruitment, but not proliferation, suffice to mediate neurodegenerationQ44055767
Parkinson disease: mechanisms of cell deathQ44400386
Conditional gene targeting in macrophages and granulocytes using LysMcre mice.Q44554898
The histopathogenesis of paralytic rabies in six-week-old C57BL/6J mice following inoculation of the CVS-11 strain into the right triceps surae muscleQ45133551
A non-invasive intranasal inoculation technique using isoflurane anesthesia to infect the brain of mice with rabies virusQ45252583
The effect of selected molecules influencing the detrimental host immune response on a course of rabies virus infection in a murine model.Q45324632
In situ apoptosis of adaptive immune cells and the cellular escape of rabies virus in CNS from patients with human rabies transmitted by Desmodus rotundusQ45369680
Pathology of the spinal cord of C57BL/6J mice infected with rabies virus (CVS-11 strain).Q45385486
Inflammatory responses in the nervous system of mice infected with a street isolate of rabies virus.Q45393367
Apoptosis and rabies virus neuroinvasion.Q45710584
Absence of the p55 Kd TNF-alpha receptor promotes survival in rabies virus acute encephalitisQ45738739
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defenceQ46064734
Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelinationQ46118529
The CARMA3-Bcl10-MALT1 Signalosome Drives NF-κB Activation and Promotes Aggressiveness in Angiotensin II Receptor-positive Breast CancerQ47233799
MALT1 controls attenuated rabies virus by inducing early inflammation and T cell activation in the brain.Q47549174
Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia culturesQ47973688
MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signalingQ48103382
The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition.Q49852317
Role of Malt1 protease activity in pathogenesis of inflammatory disorders mediated by FcγR signalingQ50134625
The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling.Q52878989
Activation of microglial cells by beta-amyloid protein and interferon-gamma.Q53202007
Borna disease. An immunopathologic response to viral infection in the CNSQ67997441
Furious and paralytic rabies of canine origin: neuroimaging with virological and cytokine studiesQ81176782
P433issue22
P407language of work or nameEnglishQ1860
P921main subjectrabiesQ39222
immunologyQ101929
rabies virusQ698976
neuronitisQ17157137
P577publication date2018-08-29
P1433published inJournal of VirologyQ1251128
P1476titleInhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice
P478volume92

Reverse relations

cites work (P2860)
Q93047664MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner
Q60924644Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function
Q91808429Monophosphoryl-Lipid A (MPLA) is an Efficacious Adjuvant for Inactivated Rabies Vaccines
Q89899084The dual role of TLR7 in the pathogenesis of rabies virus in a mouse model

Search more.