MALT1--a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression

scientific article published on 21 May 2015

MALT1--a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1111/FEBS.13325
P698PubMed publication ID25996250
P5875ResearchGate publication ID277025040

P50authorRudi BeyaertQ37382622
P2093author name stringIsabelle Carpentier
Inna S Afonina
Lynn Elton
P2860cites workA novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissueQ22010675
CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa BQ24291024
I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activityQ24298219
Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activationQ24298225
Phosphorylation of the CARMA1 linker controls NF-kappaB activationQ24298828
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosisQ24300707
T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20Q24307779
ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaBQ24336707
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytesQ24338639
NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activationQ24652716
Structural determinants of MALT1 protease activityQ27677492
Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspaseQ27685382
Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activationQ28115331
Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activationQ28189327
Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB inductionQ28198772
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family membersQ28201693
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitinationQ28201717
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiencyQ28204372
Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathwayQ28206030
Regulation and function of IKK and IKK-related kinasesQ28268930
Dectin-1: a signalling non-TLR pattern-recognition receptorQ28286159
A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusionsQ28287278
MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expressionQ28305065
Differential Requirement for Malt1 in T and B Cell Antigen Receptor SignalingQ28505229
The MAGUK family protein CARD11 is essential for lymphocyte activationQ28511124
Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decayQ28588318
Regulation of NF-κB-Dependent Lymphocyte Activation and Development by ParacaspaseQ28591729
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responsesQ29616349
Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis.Q33958556
Mechanism and specificity of the human paracaspase MALT1.Q34151837
Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activationQ34161140
T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1.Q34174201
Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.Q34211312
Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.Q34277639
Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activationQ34346617
Requirement for caspase-8 in NF-kappaB activation by antigen receptor.Q34399988
MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytesQ34432953
Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiationQ34441762
Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma.Q34457270
The proteolytic activity of the paracaspase MALT1 is key in T cell activationQ34748769
Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity.Q34806889
NF-κB signaling pathways regulated by CARMA family of scaffold proteinsQ35347919
Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunityQ35964742
A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiencyQ36979888
Multifunctional roles for MALT1 in T-cell activation.Q37198925
CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processesQ37448141
MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivoQ37699271
A20: from ubiquitin editing to tumour suppressionQ37728850
Regulation of NF-κB signaling by caspases and MALT1 paracaspaseQ37814066
Non-canonical NF-κB signaling pathwayQ37822660
A20-mediated negative regulation of canonical NF-κB signaling pathwayQ38163423
A20 in inflammation and autoimmunityQ38163677
Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation.Q39134494
The protease activity of the paracaspase MALT1 is controlled by monoubiquitination.Q39193083
Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.Q39226671
Cleavage by MALT1 induces cytosolic release of A20.Q39661717
Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cellsQ39785748
A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains.Q39843043
Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activityQ40422412
Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammationQ41240873
The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cellsQ41522425
Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammationQ41629410
The paracaspase MALT1 controls caspase-8 activation during lymphocyte proliferationQ43119003
MALT1/paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-kappaB activationQ44750362
Combined immunodeficiency associated with homozygous MALT1 mutationsQ45734660
Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelinationQ46118529
MALT lymphoma: from morphology to moleculesQ57369685
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
soldierQ4991371
P304page(s)3286-3297
P577publication date2015-05-21
P1433published inFEBS JournalQ1388041
P1476titleMALT1--a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression
P478volume282

Reverse relations

cites work (P2860)
Q26765188API2-MALT1 oncoprotein promotes lymphomagenesis via unique program of substrate ubiquitination and proteolysis
Q58761499Age-Related Chromosomal Aberrations in Patients with Diffuse Large B-Cell Lymphoma: An Approach
Q58777266CARMA3 Is a Critical Mediator of G Protein-Coupled Receptor and Receptor Tyrosine Kinase-Driven Solid Tumor Pathogenesis
Q39056717Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation
Q92798453GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein
Q47645620Identification of MALT1 as both a prognostic factor and a potential therapeutic target of regorafenib in cholangiocarcinoma patients.
Q36364264Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach
Q92021823Impact of co-blocking the costimulatory signals on immune-related genes after high-risk rabbit corneal allograft using 2nd-generation DNA sequencing technology
Q59353657Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice
Q39443989Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome
Q41625334MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage
Q93047664MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner
Q48103382MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling
Q47549174MALT1 controls attenuated rabies virus by inducing early inflammation and T cell activation in the brain.
Q37327533MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-κB and NLRP3 inflammasome activation
Q92669067MALT1 is a critical mediator of PAR1-driven NF-κB activation and metastasis in multiple tumor types
Q60924644Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function
Q39215807MicroRNA-649 promotes HSV-1 replication by directly targeting MALT1.
Q41919605Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Positively Modulates Matrix Metalloproteinase-9 Production in Alveolar Macrophages upon Toll-Like Receptor 7 Signaling and Influenza Virus Infection
Q41717303Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis
Q47119181Novel developments in the pathogenesis and diagnosis of extranodal marginal zone lymphoma
Q34521887Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation.
Q57072726The CBM-opathies-A Rapidly Expanding Spectrum of Human Inborn Errors of Immunity Caused by Mutations in the CARD11-BCL10-MALT1 Complex
Q55302804The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice.
Q46718859The FEBS Journal in 2016: read, reflect and don't feed the wolves.
Q47853157The ten-year evolutionary trajectory of a highly recurrent paediatric high grade neuroepithelial tumour with MN1:BEND2 fusion
Q59792572Treatment of Dextran Sulfate Sodium-Induced Colitis with Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Inhibitor MI-2 Is Associated with Restoration of Gut Immune Function and the Microbiota
Q36239551Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation
Q52538370Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity.

articles: null.

Warning: Trying to access array offset on value of type null in /home/httpd/vhosts/renenyffenegger.ch/opendata.renenyffenegger.ch/Wikimedia/Wikidata/entity/main.php on line 1120 Warning: Trying to access array offset on value of type null in /home/httpd/vhosts/renenyffenegger.ch/opendata.renenyffenegger.ch/Wikimedia/Wikidata/entity/main.php on line 1120

Warning: foreach() argument must be of type array|object, null given in /home/httpd/vhosts/renenyffenegger.ch/opendata.renenyffenegger.ch/Wikimedia/Wikidata/entity/main.php on line 1122

Search more.