Exercise-dependent regulation of the tumour microenvironment

scientific article published in September 2017

Exercise-dependent regulation of the tumour microenvironment is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1091911111
P356DOI10.1038/NRC.2017.78
P698PubMed publication ID28943640

P2093author name stringXiang Zhang
Richard M White
Lee W Jones
Daniela F Quail
Graeme J Koelwyn
P2860cites workSubstantial contribution of extrinsic risk factors to cancer developmentQ22251076
Hallmarks of Cancer: The Next GenerationQ22252312
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasisQ24601575
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic nicheQ24606366
Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancyQ24630087
Exercise and gene expression: physiological regulation of the human genome through physical activityQ24642012
Tumours with PI3K activation are resistant to dietary restrictionQ24650286
Exercise Regulation of Marrow Adipose TissueQ26740675
Exercise and Adipose Tissue Macrophages: New Frontiers in Obesity Research?Q26744600
Autophagy in cellular metabolism and cancerQ26996211
Modulating exercise-induced hormesis: Does less equal more?Q26997325
Effects and potential mechanisms of exercise training on cancer progression: a translational perspectiveQ27004586
Treadmill exercise induces neutrophil recruitment into muscle tissue in a reactive oxygen species-dependent manner. An intravital microscopy studyQ27334687
Targeting HIF-1 for cancer therapyQ27860504
Angiogenesis in cancer and other diseasesQ27861015
Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million AdultsQ28005550
Homeostasis, inflammation, and disease susceptibilityQ28082739
Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. AdultsQ28131763
Endothelial progenitor cells control the angiogenic switch in mouse lung metastasisQ28264314
What makes vessels grow with exercise training?Q28279253
Endurance running and the evolution of HomoQ28294017
Regulation of cancer cell metabolismQ28303890
The contraction induced increase in gene expression of peroxisome proliferator-activated receptor (PPAR)-gamma coactivator 1alpha (PGC-1alpha), mitochondrial uncoupling protein 3 (UCP3) and hexokinase II (HKII) in primary rat skeletal muscle cells iQ28569514
Physical Activity and Survival After Breast Cancer DiagnosisQ29040191
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapyQ29547379
Microenvironmental regulation of tumor progression and metastasisQ29615504
Metabolic control through the PGC-1 family of transcription coactivatorsQ29616509
American College of Sports Medicine roundtable on exercise guidelines for cancer survivorsQ37766069
'Systems biology' in human exercise physiology: is it something different from integrative physiology?Q37827643
Position statement. Part one: Immune function and exercise.Q37858972
Regulation of metabolism by hypoxia-inducible factor 1.Q37904524
Oxygen sensing, homeostasis, and diseaseQ37914865
The contribution of bone to whole-organism physiologyQ37977006
Genes associate with abnormal bone cell activity in bone metastasisQ38019409
Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymesQ38064101
Can we optimise the exercise training prescription to maximise improvements in mitochondria function and content?Q38152885
Tumor-associated macrophages: from mechanisms to therapyQ38230880
Integrative biology of exerciseQ38270563
PPARs and ERRs: molecular mediators of mitochondrial metabolismQ38285171
Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health BenefitsQ38389158
Skeletal muscle hypoxia-inducible factor-1 and exerciseQ38590535
Inflammation during skeletal muscle regeneration and tissue remodeling: application to exercise-induced muscle damage management.Q38622898
Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and RedistributionQ38792580
Bone metastasis: the importance of the neighbourhood.Q38843253
The potential of endurance exercise-derived exosomes to treat metabolic diseases.Q38845636
The role of myeloid cells in cancer therapiesQ38875474
Exercise-induced changes in tumour LDH-B and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c miceQ38882978
Obesity and Cancer Mechanisms: Cancer Metabolism.Q39024765
Metabolic origins of spatial organization in the tumor microenvironment.Q37711597
Anaerobic threshold: review of the concept and directions for future researchQ69887020
Time course of the adaptive responses of aerobic power and heart rate to trainingQ70735681
Relations of life-style with lipids, blood pressure and insulin in adolescents and young adults. The Cardiovascular Risk in Young Finns StudyQ72158542
Effects of an intensive 12-wk training program by elite swimmers on neutrophil oxidative activityQ72336392
PMN cell counts and phagocytic activity of highly trained athletes depend on training periodQ72464581
Effect of the thiol-oxidizing agent diamide on NH2Cl-induced rat colonic electrolyte secretionQ72848622
Acute phase response in exercise. III. Neutrophil and IL-1 beta accumulation in skeletal muscleQ72860138
TOBACCO and carcinoma of the lungQ73368122
Expression of the G-CSF receptor on hematopoietic progenitor cells is not required for their mobilization by G-CSFQ73783182
Immunomodulatory action of chronic exercise on macrophage and lymphocyte cytokine production in miceQ77799163
Effects of dietary calorie restriction or exercise on the PI3K and Ras signaling pathways in the skin of miceQ80655696
Endurance exercise training promotes medullary hematopoiesisQ84830684
Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese miceQ85027038
Acute exercise mobilizes hematopoietic stem and progenitor cells and alters the mesenchymal stromal cell secretomeQ87038757
Biological robustnessQ29617468
Otto Warburg's contributions to current concepts of cancer metabolismQ29617601
Wnt signalling and its impact on development and cancerQ29619273
Insulin and insulin-like growth factor signalling in neoplasiaQ29619495
Accessories to the crime: functions of cells recruited to the tumor microenvironmentQ29620161
Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesisQ29622851
Exercise Mimetics: Impact on Health and PerformanceQ30240599
Physical Activity and Cancer Outcomes: A Precision Medicine ApproachQ30249018
Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscleQ30397046
The pandemic of physical inactivity: global action for public healthQ30419494
Hunter-gatherer energetics and human obesityQ30419846
Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscleQ30428955
Emergence of spatial structure in the tumor microenvironment due to the Warburg effectQ30558209
Efficacy and Mechanisms of Aerobic Exercise on Cancer Initiation, Progression, and Metastasis: A Critical Systematic Review of In Vivo Preclinical DataQ31112729
Exercise delays allogeneic tumor growth and reduces intratumoral inflammation and vascularizationQ33199510
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory diseaseQ33402434
Effect of aerobic exercise on tumor physiology in an animal model of human breast cancerQ33656658
Randomized controlled trial of aerobic exercise on insulin and insulin-like growth factors in breast cancer survivors: the Yale Exercise and Survivorship studyQ33738383
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viabilityQ33921263
Mechanisms of bone metastasisQ33977526
Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterationsQ34017017
Exercise limitation in health and diseaseQ34018205
Exercise-induced angiogenesis-related growth and transcription factors in skeletal muscle, and their modification in muscle pathologyQ34123171
Effects of life-style modification on serum lipidsQ34127001
Bone marrow fat: linking adipocyte-induced inflammation with skeletal metastasesQ34132305
Global physical activity levels: surveillance progress, pitfalls, and prospectsQ34289497
Marrow fat and bone--new perspectivesQ34326863
Wheel Running–Induced Changes in Plasma Biomarkers and Carcinogenic Response in the 1-Methyl-1-Nitrosourea–Induced Rat Model for Breast CancerQ34332558
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.Q34429912
Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrowQ34755120
Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti-inflammatory influence of exercise?Q34802580
Association of CTNNB1 (beta-catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancerQ34921255
ATS/ACCP Statement on cardiopulmonary exercise testingQ35043791
Ultraviolet radiation and cutaneous malignant melanomaQ35146567
Periodisation of training stress--a reviewQ35232627
Periodisation and the prevention of overtrainingQ35232630
Exercise effects on polyp burden and immune markers in the ApcMin/+ mouse model of intestinal tumorigenesisQ35609240
Effect of aerobic training on the host systemic milieu in patients with solid tumours: an exploratory correlative study.Q35678685
Transcriptional regulatory circuits controlling mitochondrial biogenesis and functionQ35683727
Overtraining syndrome: a practical guideQ36215043
IL-10 triggers changes in macrophage phenotype that promote muscle growth and regenerationQ36252477
Immunological mechanisms of the antitumor effects of supplemental oxygenationQ36269330
Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and β2 integrin interactions.Q36413170
Growth factors and cancerQ36441643
The Emerging Hallmarks of Cancer MetabolismQ36468964
Characterization of the effects of exercise training on hematopoietic stem cell quantity and functionQ36473669
The role of nitric oxide in tumour progressionQ36516414
Survival Benefit of Exercise Differs by Tumor IRS1 Expression Status in Colorectal Cancer.Q36563705
Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ CommunicationQ36701865
Monocyte/Macrophage-derived IGF-1 Orchestrates Murine Skeletal Muscle Regeneration and Modulates Autocrine PolarizationQ36756794
Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise.Q36770262
Genomic landscape of non-small cell lung cancer in smokers and never-smokersQ36851245
Deconvoluting the context-dependent role for autophagy in cancerQ36876716
Blood volume response to physical activity and inactivityQ36881264
The metastatic niche: adapting the foreign soilQ36928869
.VO2max: what do we know, and what do we still need to know?Q37002313
The Colon Health and Life-Long Exercise Change trial: a randomized trial of the National Cancer Institute of Canada Clinical Trials GroupQ37011670
Mechanisms linking physical activity with cancerQ37072358
Navigating the bone marrow niche: translational insights and cancer-driven dysfunction.Q37101382
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.Q37126990
Effect of nonmotorized wheel running on mammary carcinogenesis: circulating biomarkers, cellular processes, and molecular mechanisms in ratsQ37155724
Precision Oncology Framework for Investigation of Exercise As Treatment for CancerQ37163870
Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulationsQ37219491
Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapyQ37238130
Interaction of molecular markers and physical activity on mortality in patients with colon cancerQ37350382
Exercise intolerance in cancer and the role of exercise therapy to reverse dysfunction.Q37501570
Innate immune response adaptation in mice subjected to administration of DMBA and physical activityQ37575163
Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNPQ37587761
Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy.Q37662252
Modulation of blood flow, hypoxia, and vascular function in orthotopic prostate tumors during exercise.Q37696695
Recovery of the immune system after exercise.Q39026513
Effect of exercise training on endothelial function in heart failure patients: A systematic review meta-analysis.Q39089219
Regulation of muscle growth and regeneration by the immune systemQ39120708
The evolution of lifespan and age-dependent cancer riskQ39260251
Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche.Q39321728
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.Q39507131
Interactions between ROS and AMP kinase activity in the regulation of PGC-1alpha transcription in skeletal muscle cellsQ39917673
Adaptation of macrophages to exercise training improves innate immunityQ39983104
Perivascular nitric oxide gradients normalize tumor vasculatureQ40012767
Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesisQ40167680
Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choicesQ40554692
Effects of moderate exercise and oat beta-glucan on lung tumor metastases and macrophage antitumor cytotoxicityQ40555604
New insights into the multidimensional concept of macrophage ontogeny, activation and function.Q40866271
Exercise induces autophagy in peripheral tissues and in the brainQ42531938
A framework for prescription in exercise-oncology researchQ42652182
Mouse models address key concerns regarding autophagy inhibition in cancer therapyQ42660088
Tackling obesity: challenges ahead.Q43536071
Time course-dependent changes in the transcriptome of human skeletal muscle during recovery from endurance exercise: from inflammation to adaptive remodeling.Q43819292
Effect of exercise training intensity on murine T-regulatory cells and vaccination responseQ44019199
Effects of exercise training on fasting insulin, insulin resistance, insulin-like growth factors, and insulin-like growth factor binding proteins in postmenopausal breast cancer survivors: a randomized controlled trialQ44140896
The prognostic value of a nomogram for exercise capacity in womenQ44385161
Effects of exercise dose and type during breast cancer chemotherapy: multicenter randomized trial.Q44757892
Acute aerobic exercise in humans increases cytokine expression in CD27(-) but not CD27(+) CD8(+) T-cellsQ45157017
Short-term exercise in mice increases tibial post-yield mechanical properties while two weeks of latency following exercise increases tissue-level strength.Q45354011
Muscle cytoskeletal disruption occurs within the first 15 min of cyclic eccentric contraction.Q46022186
Orrorin tugenensis femoral morphology and the evolution of hominin bipedalismQ46163791
Extensive inflammatory cell infiltration in human skeletal muscle in response to an ultraendurance exercise bout in experienced athletes.Q46211660
Randomized controlled trial of exercise and blood immune function in postmenopausal breast cancer survivors.Q46384082
Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer.Q46877011
The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (beta2 integrin) and CD53.Q46967108
Exercise-induced redistribution of T lymphocytes is regulated by adrenergic mechanismsQ46970721
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments.Q47914208
Effect of Low-Intensity Physical Activity and Moderate- to High-Intensity Physical Exercise During Adjuvant Chemotherapy on Physical Fitness, Fatigue, and Chemotherapy Completion Rates: Results of the PACES Randomized Clinical Trial.Q48039811
Exercise promotes bone marrow cell survival and recipient reconstitution post-bone marrow transplantation, which is associated with increased survival.Q50489282
Exercise capacity and mortality among men referred for exercise testing.Q50692793
Effects of 6 months of moderate aerobic exercise training on immune function in the elderly.Q51562342
SnapShot: Exercise Metabolism.Q51580588
Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production.Q51664154
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma.Q51915435
RANKL is downregulated in bone cells by physical activity (treadmill and vibration stimulation training) in rat with glucocorticoid-induced osteoporosis.Q53113258
Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial.Q53178295
Structured exercise improves physical functioning in women with stages I and II breast cancer: results of a randomized controlled trial.Q53500431
Muscle performance and enzymatic adaptations to sprint interval training.Q55067535
Aerobic exercise attenuates inducible TNF production in humansQ57117683
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1αQ59066890
Cancer robustness: Tumour tacticsQ59086311
Host Factors and Cancer OutcomeQ60595416
Swim training suppresses tumor growth in miceQ61896364
Effect of aerobic exercise on body weight and composition in patients with breast cancer on adjuvant chemotherapyQ69729362
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)620-632
P577publication date2017-09-01
P1433published inNature Reviews CancerQ641657
P1476titleExercise-dependent regulation of the tumour microenvironment
P478volume17

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cites work (P2860)
Q57296884A Prospective Study of the Association between Physical Activity and Risk of Prostate Cancer Defined by Clinical Features and TMPRSS2:ERG
Q88968371Association of Exercise With Mortality in Adult Survivors of Childhood Cancer
Q90152319Bioinformatics Analysis to Screen the Key Prognostic Genes in Tumor Microenvironment of Bladder Cancer
Q96814341Can Energetic Capacity Help Explain Why Physical Activity Reduces Cancer Risk?
Q55317070Cancer and Exercise: Warburg Hypothesis, Tumour Metabolism and High-Intensity Anaerobic Exercise.
Q90228167Efficacy and Safety of an mHealth App and Wearable Device in Physical Performance for Patients With Hepatocellular Carcinoma: Development and Usability Study
Q64977821Energy balance and gastrointestinal cancer: risk, interventions, outcomes and mechanisms.
Q57164540Evaluation of the effects of sensorimotor exercise on physical and psychological parameters in breast cancer patients undergoing neurotoxic chemotherapy
Q89690246Exercise and cancer: a position statement from the Spanish Society of Medical Oncology
Q99418687Exercise and immunometabolic regulation in cancer
Q92946073Exercise as a Candidate Antitumor Strategy: A Window into the Future
Q92714829Exercise for advanced prostate cancer: a multicomponent, feasibility, trial protocol for men with metastatic castrate-resistant prostate cancer (EXACT)
Q93182657Exercise medicine for the management of androgen deprivation therapy-related side effects in prostate cancer
Q97423378Exercise modulation of tumour perfusion and hypoxia to improve radiotherapy response in prostate cancer
Q55165862Exercise training as a novel primary treatment for localised prostate cancer: a multi-site randomised controlled phase II study.
Q91557675From NASH to HCC: current concepts and future challenges
Q61809311Hypoxia-elevated circELP3 contributes to bladder cancer progression and cisplatin resistance
Q90577149Identification of Research Priorities in Exercise Oncology: A Consensus Study
Q90480922Impact of cancer rehabilitation on the prognosis of patients with hepatocellular carcinoma
Q92540859Impacts of exercise interventions on different diseases and organ functions in mice
Q50043586Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine
Q94483651LINC01116 promotes tumor proliferation and neutrophil recruitment via DDX5-mediated regulation of IL-1β in glioma cell
Q58712309LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment
Q64248035Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype
Q60912212Metformin prevents cell tumorigenesis through autophagy-related cell death
Q56475873Molecular mechanisms of the preventable causes of cancer in the United States
Q58200565New Insights into the Role of Exercise in Inhibiting mTOR Signaling in Triple-Negative Breast Cancer
Q93000159P4HB, a Novel Hypoxia Target Gene Related to Gastric Cancer Invasion and Metastasis
Q91646491Physical Activity and Colorectal Cancer Prognosis According to Tumor-Infiltrating T Cells
Q58857098Preventable fractions of colon and breast cancers by increasing physical activity in Brazil: perspectives from plausible counterfactual scenarios
Q91975825Prolyl Isomerase Pin1 in Human Cancer: Function, Mechanism, and Significance
Q90307581The Assessment and Relationship Between Quality of Life and Physical Activity Levels in Greek Breast Cancer Female Patients under Chemotherapy
Q92633935The Regulation of the Metastatic Cascade by Physical Activity: A Narrative Review
Q64082822The obese adipose tissue microenvironment in cancer development and progression
Q91696491Toward Normalization of the Tumor Microenvironment for Cancer Therapy
Q55396890Underlying Causes and Therapeutic Targeting of the Inflammatory Tumor Microenvironment.
Q52311744Understanding the tumor immune microenvironment (TIME) for effective therapy.
Q87872287Weight, physical activity and breast cancer survival

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