Bryostatin-1 alleviates experimental multiple sclerosis.

scientific article published on 12 February 2018

Bryostatin-1 alleviates experimental multiple sclerosis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1073/PNAS.1719902115
P932PMC publication ID5834718
P698PubMed publication ID29440425

P50authorPeter CalabresiQ7173149
Matthew D SmithQ39186985
Michael D. KornbergQ40354759
P2093author name stringSolomon H Snyder
Hasti Atashi Shirazi
Paul M Kim
P2860cites workCognitive impairment in multiple sclerosisQ28300777
Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitisQ28591514
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrowQ29615498
Bryostatins: biological context and biotechnological prospects.Q34145397
Bryostatin-1, a naturally occurring antineoplastic agent, acts as a Toll-like receptor 4 (TLR-4) ligand and induces unique cytokines and chemokines in dendritic cellsQ34452508
Therapeutic effects of PKC activators in Alzheimer's disease transgenic miceQ34549472
The clinical development of the bryostatinsQ34789777
Virtues and pitfalls of EAE for the development of therapies for multiple sclerosisQ36254088
Bryostatin-1: pharmacology and therapeutic potential as a CNS drug.Q36533472
A phase II trial of bryostatin-1 administered by weekly 24-hour infusion in recurrent epithelial ovarian carcinomaQ36671119
Tamoxifen accelerates the repair of demyelinated lesions in the central nervous systemQ37198963
M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelinationQ37687158
Progressive multiple sclerosis: pathology and pathogenesisQ38046113
The "memory kinases": roles of PKC isoforms in signal processing and memory formationQ38183975
Relapsing and progressive forms of multiple sclerosis: insights from pathologyQ38203770
Animal models of Multiple Sclerosis.Q38396248
A basic overview of multiple sclerosis immunopathologyQ38587668
E6020, a synthetic TLR4 agonist, accelerates myelin debris clearance, Schwann cell infiltration, and remyelination in the rat spinal cordQ38934165
Acute oral Bryostatin-1 administration improves learning deficits in the APP/PS1 transgenic mouse model of Alzheimer's diseaseQ39071776
IL-10 mediates resistance to adoptive transfer experimental autoimmune encephalomyelitis in MyD88(-/-) miceQ39769143
Reduction of beta-amyloid levels by novel protein kinase C(epsilon) activatorsQ39784350
Protein Kinase Cϵ (PKCϵ) Promotes Synaptogenesis through Membrane Accumulation of the Postsynaptic Density Protein PSD-95Q42037616
PKC ε activation prevents synaptic loss, Aβ elevation, and cognitive deficits in Alzheimer's disease transgenic miceQ44962410
Bryostatin-1 restores hippocampal synapses and spatial learning and memory in adult fragile x miceQ44995758
Type II monocytes modulate T cell-mediated central nervous system autoimmune diseaseQ46463050
Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiationQ74405327
P4510describes a project that usesImageJQ1659584
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)2186-2191
P577publication date2018-02-12
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleBryostatin-1 alleviates experimental multiple sclerosis
P478volume115

Reverse relations

cites work (P2860)
Q93101907Bryostatin-1 ameliorated experimental colitis in Il-10-/- Mice by protecting the intestinal barrier and limiting immune dysfunction
Q92992603Glutamine antagonism attenuates physical and cognitive deficits in a model of MS
Q55483693Inhibition of Inflammation, Suppression of Matrix Metalloproteinases, Induction of Neurogenesis, and Antioxidant Property Make Bryostatin-1 a Therapeutic Choice for Multiple Sclerosis.
Q60934126Regulation of Neural Stem Cell Fate by Natural Products
Q92711767Scopoletin Suppresses Activation of Dendritic Cells and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Inhibiting NF-κB Signaling
Q92092942Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy
Q64061544Targeting Microglia and Macrophages: A Potential Treatment Strategy for Multiple Sclerosis

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