The emerging role of galectins in high-fatality cancers

scientific article published on 8 November 2017

The emerging role of galectins in high-fatality cancers is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00018-017-2708-5
P698PubMed publication ID29119229

P2093author name stringYves St-Pierre
Cherylane Dubé-Delarosbil
P2860cites workNicotine-induced resistance of non-small cell lung cancer to treatment--possible mechanismsQ26768163
Immunotherapy for hepatocellular carcinomaQ26775188
Liver transplantation for hepatocellular carcinomaQ26775214
The Role of Glycosylation in Breast Cancer Metastasis and Cancer ControlQ26777141
Global trends of lung cancer mortality and smoking prevalenceQ26784117
Nuclear transport of galectin-3 and its therapeutic implicationsQ26824889
Glioblastoma cancer stem cells: Biomarker and therapeutic advancesQ26859782
Immunotherapy for brain cancer: recent progress and future promiseQ27015881
Global cancer statistics, 2012Q27860501
Galectins: Double-edged Swords in the Cross-roads of Pregnancy Complications and Female Reproductive Tract Inflammation and NeoplasiaQ28081459
Epidemiologic and molecular prognostic review of glioblastomaQ28395302
Galectin-1-Induced Autophagy Facilitates Cisplatin Resistance of Hepatocellular CarcinomaQ28550036
Expression and functions of galectin-7 in ovarian cancer.Q30594259
Galectin-1 is implicated in the protein kinase C epsilon/vimentin-controlled trafficking of integrin-beta1 in glioblastoma cellsQ33588193
Identification of galectin-7 as a potential biomarker for esophageal squamous cell carcinoma by proteomic analysisQ33603811
Galectin-1 and its involvement in hepatocellular carcinoma aggressivenessQ33692511
Small cell lung cancer: where do we go from here?Q33872327
Galectin-3 facilitates cell motility in gastric cancer by up-regulating protease-activated receptor-1 (PAR-1) and matrix metalloproteinase-1 (MMP-1).Q34037992
Global patterns of cancer incidence and mortality rates and trendsQ34127168
Galectin-4 expression is associated with reduced lymph node metastasis and modulation of Wnt/β-catenin signalling in pancreatic adenocarcinomaQ34221829
Galectin-3 as a marker and potential therapeutic target in breast cancerQ34257030
Galectin-3 is associated with a poor prognosis in primary hepatocellular carcinomaQ34265995
Galectin-1, a gene preferentially expressed at the tumor margin, promotes glioblastoma cell invasion.Q34268364
Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activityQ34343335
Galectins as modulators of tumour progressionQ34381235
Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signalingQ34382553
Plasma levels of galectin-3-binding protein reflect type I interferon activity and are increased in patients with systemic lupus erythematosusQ34583337
Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemiaQ34635334
Novel roles of galectin-1 in hepatocellular carcinoma cell adhesion, polarization, and in vivo tumor growth.Q39578275
Lung cancer-derived galectin-1 mediates dendritic cell anergy through inhibitor of DNA binding 3/IL-10 signaling pathwayQ39614587
Galectin-3 expression is induced in cirrhotic liver and hepatocellular carcinomaQ77392016
Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancerQ80436671
Malignant mesotheliomaQ80961479
Impact of nuclear galectin-3 expression on histological differentiation and vascular invasion in patients with esophageal squamous cell carcinomaQ81253787
Galectin-9 suppresses tumor metastasis by blocking adhesion to endothelium and extracellular matricesQ81522507
Li-cadherin is inversely correlated with galectin-3 expression in gastric cancerQ81591712
Nuclear galectin-3 expression is an independent predictive factor of recurrence for adenocarcinoma and squamous cell carcinoma of the lungQ81653150
A novel approach to first-trimester screening for early pre-eclampsia combining serum PP-13 and Doppler ultrasoundQ82068160
[Expression of galectin-3 mRNA in gastric cancer with peritoneal metastasis]Q82513514
Transient silencing of galectin-3 expression promotes both in vitro and in vivo drug-induced apoptosis of human pancreatic carcinoma cellsQ83436389
Overexpression of galectin-1 is associated with poor prognosis in human hepatocellular carcinoma following resectionQ83701996
CCL2, galectin-3, and SMRP combination improves the diagnosis of mesothelioma in pleural effusionsQ84447721
High expression of Galectin-1 in pancreatic stellate cells plays a role in the development and maintenance of an immunosuppressive microenvironment in pancreatic cancerQ84584414
microRNA-22 downregulation of galectin-9 influences lymphocyte apoptosis and tumor cell proliferation in liver cancerQ85713148
Identification of novel markers for the diagnosis of malignant pleural mesotheliomaQ34760760
Galectin-4 Reduces Migration and Metastasis Formation of Pancreatic Cancer CellsQ34793403
Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinomaQ34797866
Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarraysQ34928555
Decreased galectin-9 and increased Tim-3 expression are related to poor prognosis in gastric cancerQ35067641
Galectin-4, a novel predictor for lymph node metastasis in lung adenocarcinomaQ35067654
Pancreatic satellite cells derived galectin-1 increase the progression and less survival of pancreatic ductal adenocarcinomaQ35111396
Galectin-3 up-regulation in hypoxic and nutrient deprived microenvironments promotes cell survivalQ35392528
Alarmin function of galectin-9 in murine respiratory tularemiaQ35515960
Galectin-1 is overexpressed in CD133+ human lung adenocarcinoma cells and promotes their growth and invasiveness.Q35550185
Integrated Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) Quantitative Proteomic Analysis Identifies Galectin-1 as a Potential Biomarker for Predicting Sorafenib ResistQ35692109
Expression of galectin-1 in carcinoma-associated fibroblasts promotes gastric cancer cell invasion through upregulation of integrin β1.Q35713332
Galectin-4 serves as a prognostic biomarker for the early recurrence / metastasis of hepatocellular carcinomaQ35713459
Galectin-3 augments tumor initiating property and tumorigenicity of lung cancer through interaction with β-cateninQ35741579
Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor-associated dendritic cells by expressing heparin-binding EGF-like growth factorQ35879907
Galectin-1 as a potential cancer targetQ36078029
Galectin 3 regulates HCC cell invasion by RhoA and MLCK activationQ36101399
CXCR7 stimulates MAPK signaling to regulate hepatocellular carcinoma progressionQ36291113
Expression of galectin-9 mRNA in hepatocellular carcinomaQ36464828
Survival of patients with non-small cell lung cancer without treatment: a systematic review and meta-analysisQ36630997
Clinicopathological and prognostic significance of galectin-1 and vascular endothelial growth factor expression in gastric cancerQ36759226
Serum markers for predicting pre-eclampsiaQ36833201
Galectin-1 induces hepatocellular carcinoma EMT and sorafenib resistance by activating FAK/PI3K/AKT signalingQ36866377
Galectin signatures contribute to the heterogeneity of breast cancer and provide new prognostic information and therapeutic targetsQ37109711
Potential markers of preeclampsia--a reviewQ37278804
Galectin-7 is epigenetically-regulated tumor suppressor in gastric cancerQ37299306
Lung cancer-derived galectin-1 contributes to cancer associated fibroblast-mediated cancer progression and immune suppression through TDO2/kynurenine axisQ37317333
Transient gene silencing of galectin-3 suppresses pancreatic cancer cell migration and invasion through degradation of β-cateninQ37322616
Galectin-9 plasma levels reflect adverse hematological and immunological features in acute dengue virus infection.Q37432401
First-trimester maternal serum PP13 in the risk assessment for preeclampsia.Q37444801
Proteome screening of pleural effusions identifies galectin 1 as a diagnostic biomarker and highlights several prognostic biomarkers for malignant mesotheliomaQ37623620
Gallbladder cancer: epidemiology and outcomeQ37635412
The role of quantitative mass spectrometry in the discovery of pancreatic cancer biomarkers for translational scienceQ37720601
The progress of proteomic approaches in searching for cancer biomarkersQ38060959
'Sweetening' pregnancy: galectins at the fetomaternal interfaceQ38081185
p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.Q39724417
Silencing of galectin-3 changes the gene expression and augments the sensitivity of gastric cancer cells to chemotherapeutic agentsQ39785502
Galectin-3 increases gastric cancer cell motility by up-regulating fascin-1 expressionQ39789149
Suppression of galectin-3 expression enhances apoptosis and chemosensitivity in liver fluke-associated cholangiocarcinomaQ39805315
Galectin-1-mediated tumor invasion and metastasis, up-regulated matrix metalloproteinase expression, and reorganized actin cytoskeletonsQ39874836
Role of galectin-1 in migration and invasion of human glioblastoma multiforme cell linesQ39955272
Knocking down galectin 1 in human hs683 glioblastoma cells impairs both angiogenesis and endoplasmic reticulum stress responsesQ39989272
Pancreatic stellate cells promote proliferation and invasiveness of human pancreatic cancer cells via galectin-3Q39994161
Evidence of galectin-1 involvement in glioma chemoresistanceQ40006970
Galectin-3 may contribute to Cisplatin resistance in clear cell carcinoma of the ovaryQ40145990
Galectin-7 in lymphoma: elevated expression in human lymphoid malignancies and decreased lymphoma dissemination by antisense strategies in experimental modelQ40158300
Galectin-1 knocking down in human U87 glioblastoma cells alters their gene expression patternQ40392221
Multifaceted role of galectin-3 on human glioblastoma cell motilityQ40489819
Galectin-3: differential expression between small-cell and non-small-cell lung cancerQ40521621
Role of galectin-3 in plasma as a predictive biomarker of outcome after acute intracerebral hemorrhageQ40616519
Galectin-3 expression alters adhesion, motility and invasion in a lung cell line (DLKP), in vitro.Q40677265
Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreasQ40733113
Expression of endogenous galectin-1 and galectin-3 in intrahepatic cholangiocarcinomaQ40817943
Concentrations of galectin-3 in the sera of normal controls and cancer patientsQ40884459
Anginex, a designed peptide that inhibits angiogenesisQ41874982
Targeting Galectin-1 in pancreatic cancer: immune surveillance on guardQ42030543
Expression of adhesion factors and degrading proteins in primary and secondary glioblastomas and their precursor tumorsQ42485404
Galectin-3 germline variant at position 191 enhances nuclear accumulation and activation of β-catenin in gastric cancerQ42730725
Galectin-3 binds to MUC1-N-terminal domain and triggers recruitment of β-catenin in MUC1-expressing mouse 3T3 cellsQ42806313
Anaplastic glioma: how to prognosticate outcome and choose a treatment strategy. [corrected].Q43245400
Role of galectin-3 in adenocarcinoma liver metastasisQ43769106
Deregulated expression of annexin-A2 and galectin-3 is associated with metastasis in gastric cancer patientsQ44253238
Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma.Q45358316
Glioma-derived galectin-1 regulates innate and adaptive antitumor immunity.Q45945651
Expression of Gal-3 and CD82/KAI1 proteins in non-small cell lung cancer and their clinical significanceQ46052125
Expression of galectin-3 involved in prognosis of patients with hepatocellular carcinomaQ46442908
Galectin-1 induces chemokine production and proliferation in pancreatic stellate cellsQ46864651
Galectins: a family of animal beta-galactoside-binding lectinsQ48084852
Galectin-1 modulates human glioblastoma cell migration into the brain through modifications to the actin cytoskeleton and levels of expression of small GTPasesQ48543365
Expression of the endogenous galactose-binding protein galectin-3 correlates with the malignant potential of tumors in the central nervous systemQ48637099
Galectin-1 is highly expressed in human gliomas with relevance for modulation of invasion of tumor astrocytes into the brain parenchymaQ48958266
Galectins are differentially expressed in supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas, and significantly modulate tumor astrocyte migration.Q49108957
Up-regulation of galectin-3 and Sambucus nigra agglutinin binding site is associated with invasion, metastasis and poor-progression of the gallbladder adenocarcinomaQ50174633
Galectin-3 knockdown increases gefitinib sensitivity to the inhibition of EGFR endocytosis in gefitinib-insensitive esophageal squamous cancer cells.Q50997794
Increased levels of galectin-3 were associated with prediabetes and diabetes: new risk factor?Q51311008
RN1, a novel galectin-3 inhibitor, inhibits pancreatic cancer cell growth in vitro and in vivo via blocking galectin-3 associated signaling pathways.Q51518944
[Serum and tissue expressions of galectin-3 in hepatocellular carcinoma and the clinical significances].Q53277840
Galectin-1 Controls the Proliferation and Migration of Liver Sinusoidal Endothelial Cells and Their Interaction With Hepatocarcinoma Cells.Q53284113
Evidence for the role of 34-kDa galactoside-binding lectin in transformation and metastasis.Q53503954
Apoptosis and anergy of T cell induced by pancreatic stellate cells-derived galectin-1 in pancreatic cancer.Q53600526
Clinical significance of galectin-7 in epithelial ovarian cancer.Q54264856
Expression of galectin-1 mRNA correlates with the malignant potential of human gliomas and expression of antisense galectin-1 inhibits the growth of 9 glioma cells.Q55476008
Clinical significance of circulating galectins as colorectal cancer markersQ56601187
Gallbladder cancerQ57653775
Galectin-3 expression in non-small cell lung carcinomaQ57893121
Comparative analysis of galectins in primary tumors and tumor metastasis in human pancreatic cancerQ73644483
Localization of galectin-3 in normal and diseased pancreatic tissueQ74372136
Immunohistochemical profile of galectin-8 expression in benign and malignant tumors of epithelial, mesenchymatous and adipous origins, and of the nervous systemQ74393002
Management of non-small-cell lung cancer: recent developmentsQ38131165
Treatment of hepatocellular carcinoma: a systematic reviewQ38155508
Intracellular galectins in cancer cells: potential new targets for therapy (Review).Q38180976
Expression, localization and function of galectin-8, a tandem-repeat lectin, in human tumorsQ38201698
Galectin-3 in diabetic patientsQ38221153
Non-small-cell lung cancers: a heterogeneous set of diseasesQ38233321
Galectin-3 inhibitors: a patent review (2008-present).Q38238525
Targeted disruption of the galectin-3 gene results in decreased susceptibility to NNK-induced lung tumorigenesis: an oligonucleotide microarray studyQ38294425
Galectin-3 expressed on different lung compartments promotes organ specific metastasis by facilitating arrest, extravasation and organ colonization via high affinity ligands on melanoma cells.Q38306237
Targeting specific molecular pathways holds promise for advanced gallbladder cancer therapy.Q38339507
Molecular targeted therapy in the treatment of advanced stage non-small cell lung cancer (NSCLC).Q38358410
Targeted therapy for non-small cell lung cancer: current standards and the promise of the futureQ38390200
Galectin-3 and aldosterone as potential tandem biomarkers in pulmonary arterial hypertensionQ38410318
Prognostic value of galectin-3 in patients with heart failureQ38471023
Galectin-1 inhibitors and their potential therapeutic applications: a patent reviewQ38763827
Knockdown of LI-cadherin alters expression of matrix metalloproteinase-2 and -9 and galectin-3.Q38781609
Galectin-9: An anticancer molecule for gallbladder carcinomaQ38800628
Galectin-9 suppresses the proliferation of gastric cancer cells in vitroQ38807956
Galectin-3 modulates the EGFR signalling-mediated regulation of Sox2 expression via c-Myc in lung cancerQ38829578
Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing apoptosis but not cell cycle arrestQ38844680
Galectin-9 suppresses the growth of hepatocellular carcinoma via apoptosis in vitro and in vivoQ38893144
Expression of mucin 1 possessing a 3'-sulfated core1 in recurrent and metastatic breast cancerQ38897800
Galectin-1 triggers epithelial-mesenchymal transition in human hepatocellular carcinoma cellsQ38932655
Peroxisome proliferator-activated receptor γ upregulates galectin-9 and predicts prognosis in intestinal-type gastric cancer.Q38979843
Galectin-3 and matrix metalloproteinase-9: Perspective in management of hepatocellular carcinoma.Q38983451
Role of downregulation of galectin-9 in the tumorigenesis of gastric cancerQ38985834
Downregulation of galectin-3 causes a decrease in uPAR levels and inhibits the proliferation, migration and invasion of hepatocellular carcinoma cellsQ38997262
An EpCAM/CD3 bispecific antibody efficiently eliminates hepatocellular carcinoma cells with limited galectin-1 expressionQ39068110
Galectin-1 promotes lung cancer tumor metastasis by potentiating integrin α6β4 and Notch1/Jagged2 signaling pathwayQ39198397
Galectin-9 acts as a prognostic factor with antimetastatic potential in hepatocellular carcinoma.Q39287639
Galectin-1 promotes lung cancer progression and chemoresistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2.Q39331669
Galectin-9 signaling prolongs survival in murine lung-cancer by inducing macrophages to differentiate into plasmacytoid dendritic cell-like macrophagesQ39426827
Galectin-1 secreted by activated stellate cells in pancreatic ductal adenocarcinoma stroma promotes proliferation and invasion of pancreatic cancer cells: an in vitro study on the microenvironment of pancreatic ductal adenocarcinomaQ39508641
P577publication date2017-11-08
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleThe emerging role of galectins in high-fatality cancers

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cites work (P2860)
Q90073141Galectin-3 as a Next-Generation Biomarker for Detecting Early Stage of Various Diseases
Q91707625Galectin-7 is elevated in endometrioid (type I) endometrial cancer and promotes cell migration

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