Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial

scientific article published on 5 February 2018

Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1473-3099(18)30044-6
P932PMC publication ID5968371
P698PubMed publication ID29422384

P50authorAlassane DickoQ72250716
Roly GoslingQ90760327
Harouna M SoumareQ102203891
Jimee HwangQ102205364
Joelle BrownQ114369292
Kjerstin H W LankeQ114401434
Halimatou DiawaraQ114402289
Sékou TraoréQ114755887
Ingrid ChenQ117278017
Almahamoudou MahamarQ117278018
Koualy SanogoQ117278019
Teun BousemaQ44168464
Chris J DrakeleyQ56774786
Vinay SrinivasanQ57905260
John BradleyQ64605853
P2093author name stringOlaf Müller
Charles McCulloch
Michelle E Roh
Will J R Stone
Sekouba Keita
Daouda T Kone
Djibrilla Issiaka
Kalifa Diarra
P2860cites workStrong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomised controlled trialQ21562479
The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015Q28267425
Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunateQ28469316
Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria: a randomized controlled trial from Burkina FasoQ28472182
A randomised trial to compare the safety, tolerability and efficacy of three drug combinations for intermittent preventive treatment in childrenQ28474568
Reducing Plasmodium falciparum malaria transmission in Africa: a model-based evaluation of intervention strategiesQ28475084
Single Low Dose Primaquine (0.25 mg/kg) Does Not Cause Clinically Significant Haemolysis in G6PD Deficient SubjectsQ28550990
Effectiveness of Seasonal Malaria Chemoprevention in Children under Ten Years of Age in Senegal: A Stepped-Wedge Cluster-Randomised TrialQ28553641
Randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria intermittent preventive treatment in childrenQ33507089
Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugsQ33898575
The effect of primaquine on gametocyte development and clearance in the treatment of uncomplicated falciparum malaria with dihydroartemisinin-piperaquine in South sumatra, Western indonesia: an open-label, randomized, controlled trialQ34486508
Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malariaQ34968407
Mass campaigns with antimalarial drugs: a modelling comparison of artemether-lumefantrine and DHA-piperaquine with and without primaquine as tools for malaria control and eliminationQ35224221
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blueQ35571456
Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugsQ36969808
Short-term Impact of Mass Drug Administration With Dihydroartemisinin Plus Piperaquine on Malaria in Southern Province Zambia: A Cluster-Randomized Controlled TrialQ37480626
Impact of intermittent preventive treatment with dihydroartemisinin-piperaquine on malaria in Ugandan schoolchildren: a randomized, placebo-controlled trialQ37726083
Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trialQ38904423
Efficacy and safety of triple combination therapy with artesunate-amodiaquine-methylene blue for falciparum malaria in children: a randomized controlled trial in Burkina FasoQ38954634
Modelling the benefits of long-acting or transmission-blocking drugs for reducing Plasmodium falciparum transmission by case management or by mass treatmentQ40081071
Malaria Infection and Gametocyte Carriage Rates in Preparation for Transmission Blocking Vaccine Trials in Bancoumana, MaliQ40118476
Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparumQ41944750
Artemisinin resistance on the Thai-Cambodian borderQ43255541
Haemolysis risk in methylene blue treatment of G6PD-sufficient and G6PD-deficient West-African children with uncomplicated falciparum malaria: a synopsis of four RCTsQ43929062
Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparumQ44167789
A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte ClearanceQ44168409
Malaria transmission after artemether-lumefantrine and dihydroartemisinin-piperaquine: a randomized trialQ44168825
Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment TrialQ48022321
P433issue6
P921main subjectMaliQ912
Plasmodium falciparumQ311383
phase II clinical trialQ42824440
P304page(s)627-639
P577publication date2018-02-06
P1433published inLancet Infectious DiseasesQ15724248
P1476titleEfficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial
P478volume18

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cites work (P2860)
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