A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte Clearance

scientific article published in August 2017

A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte Clearance is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/INFDIS/JIX237
P8608Fatcat IDrelease_ifnnva2blrgvlo2qkw5zsny7fe
P932PMC publication ID5853855
P698PubMed publication ID28931236

P50authorAlassane DickoQ72250716
Will StoneQ84532639
Roly GoslingQ90760327
Joelle BrownQ114369292
Kjerstin H W LankeQ114401434
Halimatou DiawaraQ114402289
Patrick SawaQ116791378
Ingrid ChenQ117278017
Almahamoudou MahamarQ117278018
Teun BousemaQ44168464
Marga van de Vegte-BolmerQ45380602
Giulia SicilianoQ56351405
Chris J DrakeleyQ56774786
Wouter GraumansQ56781303
John BradleyQ64605853
P2093author name stringPietro Alano
Victor Osoti
Rob Woestenenk
Robin Oriango
Maureen Nyaurah
Paul Osodo
Sanna Rijpma
P2860cites workThe effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015Q28267425
Primaquine clears submicroscopic Plasmodium falciparum gametocytes that persist after treatment with sulphadoxine-pyrimethamine and artesunateQ28469316
Modelling the impact of artemisinin combination therapy and long-acting treatments on malaria transmission intensityQ28474141
Mosquito feeding assays to determine the infectiousness of naturally infected Plasmodium falciparum gametocyte carriersQ28482471
Substantial contribution of submicroscopical Plasmodium falciparum gametocyte carriage to the infectious reservoir in an area of seasonal transmissionQ33520254
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individualsQ33826283
Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugsQ33898575
A sub-microscopic gametocyte reservoir can sustain malaria transmission.Q33939379
Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trialQ34038938
Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and eliminationQ34177472
Primaquine therapy for malariaQ34360516
The plasticity of Plasmodium falciparum gametocytaemia in relation to age in Burkina FasoQ34488590
Microsporidians as evolution-proof agents of malaria control?Q34963147
Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malariaQ34968407
Improving statistical inference on pathogen densities estimated by quantitative molecular methods: malaria gametocytaemia as a case studyQ35016799
Single low dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission after artemether-lumefantrine in children with asymptomatic infection: a randomised, double-blind, placebo-controlled trialQ35948587
Factors determining the occurrence of submicroscopic malaria infections and their relevance for controlQ36503207
Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is commonQ36538990
Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trialsQ36800842
Predicting mosquito infection from Plasmodium falciparum gametocyte density and estimating the reservoir of infectionQ36864852
Plasmodium falciparum gametocyte sex ratios in children with acute, symptomatic, uncomplicated infections treated with amodiaquineQ36889810
Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugsQ36969808
Comparison of molecular quantification of Plasmodium falciparum gametocytes by Pfs25 qRT-PCR and QT-NASBA in relation to mosquito infectivityQ37400894
Population structure of Plasmodium falciparum gametocyte sex ratios in malarious children in an endemic areaQ37434808
Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repressionQ37623775
Gametocytocidal and sporontocidal effects of primaquine upon two strains of Plasmodium falciparumQ38896552
Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trialQ38904423
Quantification of female and male Plasmodium falciparum gametocytes by reverse transcriptase quantitative PCR.Q39438001
Primaquine to prevent transmission of falciparum malariaQ39589821
Effect of gametocyte sex ratio on infectivity of Plasmodium falciparum to Anopheles gambiaeQ43482943
Submicroscopic Plasmodium falciparum gametocyte carriage is common in an area of low and seasonal transmission in TanzaniaQ43736591
Effect of antimalarial drugs on Plasmodium falciparum gametocytes.Q44148341
Plasmodium falciparum gametocyte carriage, emergence, clearance and population sex ratios in anaemic and non-anaemic malarious childrenQ44160005
Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparumQ44167789
Malaria transmission after artemether-lumefantrine and dihydroartemisinin-piperaquine: a randomized trialQ44168825
Submicroscopic Plasmodium falciparum gametocyte densities frequently result in mosquito infection.Q44171862
Artesunate combinations for treatment of malaria: meta-analysisQ44728450
(Sub)microscopic Plasmodium falciparum gametocytaemia in Kenyan children after treatment with sulphadoxine-pyrimethamine monotherapy or in combination with artesunateQ46962726
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectPlasmodium falciparumQ311383
P304page(s)457-467
P577publication date2017-08-01
P1433published inJournal of Infectious DiseasesQ4051141
P1476titleA Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte Clearance
P478volume216

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cites work (P2860)
Q47547431A controlled human malaria infection model enabling evaluation of transmission-blocking interventions
Q59801146A multiplex assay for the sensitive detection and quantification of male and female Plasmodium falciparum gametocytes
Q50318730A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model
Q64104023Biology of Plasmodium falciparum gametocyte sex ratio and implications in malaria parasite transmission
Q92429984CYP2D6 Polymorphisms and the Safety and Gametocytocidal Activity of Single-Dose Primaquine for Plasmodium falciparum
Q40105545Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assays
Q64110172DSM265 at 400 Milligrams Clears Asexual Stage Parasites but Not Mature Gametocytes from the Blood of Healthy Subjects Experimentally Infected with
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Q50107885Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial
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Q62738091Gametocyte Sex Ratio: The Key to Understanding Plasmodium falciparum Transmission?
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Q52683433On a mission to block transmission.
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Q48022828Variation in natural exposure to anopheles mosquitoes and its effects on malaria transmission

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