A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

scientific article published on 27 February 2018

A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.7554/ELIFE.31549
P932PMC publication ID5828662
P698PubMed publication ID29482720

P50authorLisette Meerstein-KesselQ72536115
Christian F OckenhouseQ106991965
Kjerstin H W LankeQ114401434
Karina TeelenQ115215275
Teun BousemaQ44168464
Marga van de Vegte-BolmerQ45380602
Rianne Siebelink-StoterQ45380608
Katharine A CollinsQ55175774
Luc E CoffengQ55188920
Isaie J ReulingQ56384676
Wouter GraumansQ56781303
Robert W SauerweinQ60043950
John BradleyQ64605853
P2093author name stringGeert-Jan van Gemert
Quirijn de Mast
Cornelus C Hermsen
James McCarthy
Karen Ivinson
Sake de Vlas
André J van der Ven
Lisanne A van de Schans
P2860cites workThe relevance and applicability of oocyst prevalence as a read-out for mosquito feeding assaysQ26315349
Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient dataQ28068072
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Reducing Plasmodium falciparum malaria transmission in Africa: a model-based evaluation of intervention strategiesQ28475084
Mosquito feeding assays to determine the infectiousness of naturally infected Plasmodium falciparum gametocyte carriersQ28482471
A transcriptional switch underlies commitment to sexual development in malaria parasitesQ30041370
Genesis, sequestration and survival of Plasmodium falciparum gametocytes: parameter estimates from fitting a model to malariatherapy dataQ30665506
Initiation of gametocytogenesis at very low parasite density in Plasmodium falciparum infection.Q33662226
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Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugsQ33898575
Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and eliminationQ34177472
Operational strategies to achieve and maintain malaria eliminationQ34568019
Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malariaQ34968407
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blueQ35571456
Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria TransmissionQ36215894
A comparison of Plasmodium falciparum circumsporozoite protein-based slot blot and ELISA immuno-assays for oocyst detection in mosquito homogenatesQ36287262
Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugsQ36969808
Piperaquine Monotherapy of Drug-Susceptible Plasmodium falciparum Infection Results in Rapid Clearance of Parasitemia but Is Followed by the Appearance of Gametocytemia.Q37003081
A humanized mouse model for sequestration of Plasmodium falciparum sexual stages and in vivo evaluation of gametocytidal drugsQ37330567
Comparison of molecular quantification of Plasmodium falciparum gametocytes by Pfs25 qRT-PCR and QT-NASBA in relation to mosquito infectivityQ37400894
A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype-genotype association studyQ37607320
New medicines to improve control and contribute to the eradication of malariaQ37615897
Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repressionQ37623775
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Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, UgandaQ38882145
Can field-based mosquito feeding assays be used for evaluating transmission-blocking interventions?Q38917760
Primaquine to prevent transmission of falciparum malariaQ39589821
Synchronization of Plasmodium falciparum gametocytes using an automated suspension culture systemQ68919204
A study of gametocytes in a West African strain of Plasmodium falciparumQ75685108
Semi-high-throughput detection of Plasmodium falciparum and Plasmodium vivax oocysts in mosquitoes using bead-beating followed by circumsporozoite ELISA and quantitative PCR.Q40064136
Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assaysQ40105545
Antimalarial drugs and the mosquito transmission of PlasmodiumQ41639184
Infectivity of cultured Plasmodium falciparum gametocytes to mosquitoesQ41946006
Determinants of treatment response to sulfadoxine-pyrimethamine and subsequent transmission potential in falciparum malariaQ44030140
Mechanisms that reduce transmission of Plasmodium falciparum malaria in semiimmune and nonimmune personsQ44138775
Detection of Plasmodium falciparum malaria parasites in vivo by real-time quantitative PCR.Q44146886
A combination of new screening assays for prioritization of transmission-blocking antimalarials reveals distinct dynamics of marketed and experimental drugsQ44148145
Infectivity of Microscopic and Submicroscopic Malaria Parasite Infections in Areas of Low Malaria EndemicityQ44155243
Experimental human challenge infections can accelerate clinical malaria vaccine developmentQ44156054
A consultation on the optimization of controlled human malaria infection by mosquito bite for evaluation of candidate malaria vaccinesQ44164288
A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte ClearanceQ44168409
Measurement of Plasmodium falciparum growth rates in vivo: a test of malaria vaccinesQ45037329
Quantification of Plasmodium falciparum gametocytes in differential stages of development by quantitative nucleic acid sequence-based amplificationQ47990457
P407language of work or nameEnglishQ1860
P921main subjectmalariaQ12156
Plasmodium falciparumQ311383
antimalarialQ521616
P577publication date2018-02-27
P1433published ineLifeQ2000008
P1476titleA randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model
P478volume7

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cites work (P2860)
Q59801146A multiplex assay for the sensitive detection and quantification of male and female Plasmodium falciparum gametocytes
Q61447733Antibody Responses to Antigenic Targets of Recent Exposure Are Associated With Low-Density Parasitemia in Controlled Human Infections
Q62738091Gametocyte Sex Ratio: The Key to Understanding Plasmodium falciparum Transmission?
Q92463531How delayed and non-adherent treatment contribute to onward transmission of malaria: a modelling study
Q92001627Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites
Q58714876Liver Injury in Uncomplicated Malaria is an Overlooked Phenomenon: An Observational Study
Q52683433On a mission to block transmission.
Q91807410Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial
Q92413853The XN-30 hematology analyzer for rapid sensitive detection of malaria: a diagnostic accuracy study

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