Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest

scientific article published on 5 February 2018

Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKY050
P932PMC publication ID5909423
P698PubMed publication ID29415157

P50authorVictoriia MurinaQ64189317
Gemma AtkinsonQ37380056
Vasili HauryliukQ37380082
P2093author name stringMarje Kasari
P2860cites workATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimerQ24602726
Ribosomal protection proteins and their mechanism of tetracycline resistanceQ24628384
Structure, function, and evolution of bacterial ATP-binding cassette systemsQ24643436
Ribosome formation from subunits studied by stopped-flow and rayleigh light scatteringQ24805320
Direct binding targets of the stringent response alarmone (p)ppGppQ26995737
Resistance to linezolid caused by modifications at its binding site on the ribosomeQ27006772
U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:Q27654656
Functional interplay between the ATP binding cassette Msr(D) protein and the membrane facilitator superfamily Mef(E) transporter for macrolide resistance in Escherichia coli.Q50486425
Staphylococcus aureus SH1000 and 8325-4: comparative genome sequences of key laboratory strains in staphylococcal research.Q52847405
Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome.Q54539576
The Specificity of Lincomycin Binding to Ribosomes*Q72221331
Tetracycline antibiotics and resistance mechanisms.Q38185338
Invited review: Architectures and mechanisms of ATP binding cassette proteinsQ38796195
Bacterial Protein Synthesis as a Target for Antibiotic InhibitionQ38915765
Lincosamides, Streptogramins, Phenicols, and Pleuromutilins: Mode of Action and Mechanisms of ResistanceQ38934153
Characterization and prevalence of MefA, MefE, and the associated msr(D) gene in Streptococcus pneumoniae clinical isolatesQ39485994
ABC-F Proteins Mediate Antibiotic Resistance through Ribosomal ProtectionQ39486737
HPLC-based quantification of bacterial housekeeping nucleotides and alarmone messengers ppGpp and pppGppQ40059610
Subinhibitory Concentrations of Bacteriostatic Antibiotics Induce relA-Dependent and relA-Independent Tolerance to β-Lactams.Q40361184
A new evolutionary variant of the streptogramin A resistance protein, Vga(A)LC, from Staphylococcus haemolyticus with shifted substrate specificity towards lincosamidesQ40902773
Molecular analysis of resistance to streptogramin A compounds conferred by the Vga proteins of staphylococciQ41091598
The ABC of Ribosome-Related Antibiotic ResistanceQ42017729
Detailed mutational analysis of Vga(A) interdomain linker: implication for antibiotic resistance specificity and mechanismQ42076814
Structural insights of lincosamides targeting the ribosome of Staphylococcus aureusQ42140527
Macrolide efflux in Streptococcus pneumoniae is mediated by a dual efflux pump (mel and mef) and is erythromycin inducibleQ42564810
Structure and dissemination of a chromosomal insertion element encoding macrolide efflux in Streptococcus pneumoniaeQ42651721
ABC proteins and antibiotic drug resistance: is it all about transport?Q42671724
The conserved glutamate residue adjacent to the Walker-B motif is the catalytic base for ATP hydrolysis in the ATP-binding cassette transporter BmrA.Q44580830
Identification of novel vga(A)-carrying plasmids and a Tn5406-like transposon in meticillin-resistant Staphylococcus aureus and Staphylococcus epidermidis of human and animal origin.Q45234923
Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistanceQ46455040
Hsp110 is a nucleotide-activated exchange factor for Hsp70.Q46792599
Sequence of a staphylococcal plasmid gene, vga, encoding a putative ATP-binding protein involved in resistance to virginiamycin A-like antibioticsQ48162418
Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug actionQ27664697
Revisiting the structures of several antibiotics bound to the bacterial ribosomeQ27664704
Snapshots of the maltose transporter during ATP hydrolysisQ27671623
Mechanism of tetracycline resistance by ribosomal protection protein Tet(O)Q27676345
EttA regulates translation by binding the ribosomal E site and restricting ribosome-tRNA dynamicsQ27681174
The ABC-F protein EttA gates ribosome entry into the translation elongation cycleQ27681176
CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance databaseQ28584458
RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogeniesQ28658397
Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coliQ29615316
Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus RibosomeQ33654525
When an ATPase is not an ATPase: at low temperatures the C-terminal domain of the ABC transporter CvaB is a GTPaseQ33726448
An Enterococcus faecalis ABC homologue (Lsa) is required for the resistance of this species to clindamycin and quinupristin-dalfopristinQ34109292
Peptidyl-Puromycin Synthesis on Polyribosomes from Escherichia coliQ34692966
The evolutionary and functional diversity of classical and lesser-known cytoplasmic and organellar translational GTPases across the tree of lifeQ35127797
Cryo-EM structure of the tetracycline resistance protein TetM in complex with a translating ribosome at 3.9-Å resolutionQ35567060
Antibiotics currently used in the treatment of infections caused by Staphylococcus aureusQ36306700
Molecular basis for differential nucleotide binding of the nucleotide-binding domain of ABC-transporter CvaB.Q36836298
Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteriaQ36931422
Genetic basis for in vitro and in vivo resistance to lincosamides, streptogramins A, and pleuromutilins (LSAP phenotype) in Enterococcus faecium.Q37124174
Outer membrane permeability and antibiotic resistanceQ37227443
Nucleoside triphosphate regeneration decreases the frequency of translation errorsQ37335694
A structural view on the mechanism of the ribosome-catalyzed peptide bond formationQ37549187
UniProt: the universal protein knowledgebaseQ37556842
β-lactamase-mediated resistance: a biochemical, epidemiological and genetic overviewQ38034798
Streptogramins - two are better than one!Q38152022
Ribosome-targeting antibiotics and mechanisms of bacterial resistance.Q38171225
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectantibiotic resistanceQ380775
P304page(s)3753-3763
P577publication date2018-04-01
P1433published inNucleic Acids ResearchQ135122
P1476titleAntibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest
P478volume46

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cites work (P2860)
Q94563357A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes
Q59798774Antibiotic Resistance Mechanisms in Bacteria: Relationships Between Resistance Determinants of Antibiotic Producers, Environmental Bacteria, and Clinical Pathogens
Q64093336High-Level Macrolide Resistance Due to the Mega Element [(E)/] in
Q90050542Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA
Q64106021Omnipresent Maxwell's demons orchestrate information management in living cells
Q53689783Ribosome protection by antibiotic resistance ATP-binding cassette protein.
Q58279739Structural basis for antibiotic resistance mediated by the ABCF ATPase VmlR
Q96686068Target protection as a key antibiotic resistance mechanism
Q90411042The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of 'Long' RelA-SpoT Homolog Enzymes by Ribosomal Complexes
Q91748815Translational control of antibiotic resistance

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