Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA

scientific article published on 27 August 2019

Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA is …
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scholarly articleQ13442814

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P356DOI10.3389/FMICB.2019.01966
P932PMC publication ID6719525
P698PubMed publication ID31507571

P50authorSøren LindemoseQ57207616
Vasili HauryliukQ37380082
P2093author name stringMohammad Roghanian
Ievgen Dzhygyr
Kathryn Jane Turnbull
P2860cites workThe RelA/SpoT homolog (RSH) superfamily: distribution and functional evolution of ppGpp synthetases and hydrolases across the tree of lifeQ21135259
Synthesis of Guanosine Tetra- and Pentaphosphate Requires the Presence of a Codon-Specific, Uncharged Transfer Ribonucleic Acid in the Acceptor Site of RibosomesQ24564295
Ribosome formation from subunits studied by stopped-flow and rayleigh light scatteringQ24805320
The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesisQ27705295
Thermodynamic characterization of ppGpp binding to EF-G or IF2 and of initiator tRNA binding to free IF2 in the presence of GDP, GTP, or ppGppQ28290627
Gene disruption in Escherichia coli: TcR and KmR cassettes with the option of Flp-catalyzed excision of the antibiotic-resistance determinantQ29615039
Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resourcesQ33551343
ppGpp conjures bacterial virulenceQ33909091
Regulation of Escherichia coli RelA requires oligomerization of the C-terminal domainQ33995334
Intramolecular regulation of the opposing (p)ppGpp catalytic activities of Rel(Seq), the Rel/Spo enzyme from Streptococcus equisimilisQ34312090
The nucleotide-binding site of bacterial translation initiation factor 2 (IF2) as a metabolic sensorQ35080376
Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA.Q51747914
High concentrations of ppGpp decrease the RNA chain growth rate. Implications for protein synthesis and translational fidelity during amino acid starvation in Escherichia coli.Q54640072
Overexpression of the relA gene in Escherichia coli.Q54700280
The physiology of stringent factor (ATP:GTP 3'-diphosphotransferase) in Escherichia coli.Q54781207
Birth and Resuscitation of (p)ppGpp Induced Antibiotic Tolerant Persister CellsQ64115436
The Escherichia coli relBE genes belong to a new toxin-antitoxin gene familyQ77394553
Activation of the Stringent Response by Loading of RelA-tRNA Complexes at the Ribosomal A-SiteQ88292774
The Rel stringent factor from Thermus thermophilus: crystallization and X-ray analysisQ92518326
Regulation of (p)ppGpp hydrolysis by a conserved archetypal regulatory domainQ93367430
ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteriaQ35948392
Recent functional insights into the role of (p)ppGpp in bacterial physiologyQ36319374
Molecular dissection of the mycobacterial stringent response protein RelQ36458404
Genome Sequence and Analysis of Escherichia coli MRE600, a Colicinogenic, Nonmotile Strain that Lacks RNase I and the Type I Methyltransferase, EcoKIQ36780152
Biochemical bases for the antimetabolite action of L-serine hydroxamateQ36795865
The quantitative and condition-dependent Escherichia coli proteomeQ36956238
Ribosome•RelA structures reveal the mechanism of stringent response activation.Q37152941
Immobilized-metal affinity chromatography (IMAC): a reviewQ37628094
ppGpp: magic beyond RNA polymeraseQ37984220
Characterization of the tRNA and ribosome-dependent pppGpp-synthesis by recombinant stringent factor from Escherichia coliQ38331457
Rapid Curtailing of the Stringent Response by Toxin-Antitoxin Module-Encoded mRNases.Q39801859
Clustering of genes involved in replication, copy number control, incompatibility, and stable maintenance of the resistance plasmid R1drd-19.Q39978177
Analysis of the relA Gene Product of Escherichia coliQ40084061
Isoleucine and valine metabolism in Escherichia coli. XI. Valine inhibition of the growth of Escherichia coli strain K-12Q40259842
Correlation between the serine sensitivity and the derepressibility of the ilv genes in Escherichia coli relA- mutantsQ40958783
Ribosome-dependent activation of stringent controlQ41601756
CRP-dependent positive autoregulation and proteolytic degradation regulate competence activator Sxy of Escherichia coliQ41710433
The ribosome triggers the stringent response by RelA via a highly distorted tRNAQ41809118
Positive allosteric feedback regulation of the stringent response enzyme RelA by its productQ41850367
Biochemical studies on Francisella tularensis RelA in (p)ppGpp biosynthesisQ41888462
Dimerization of the RelA protein of Escherichia coliQ43859794
Dissection of the mechanism for the stringent factor RelA.Q44206960
Guanosine tetraphosphate inhibits protein synthesis in vivo. A possible protective mechanism for starvation stress in Escherichia coliQ46263543
The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA.Q49489064
Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrestQ50132954
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageQuantQ112270642
P921main subjectEscherichia coliQ25419
P304page(s)1966
P577publication date2019-08-27
P1433published inFrontiers in MicrobiologyQ27723481
P1476titleIntramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA
P478volume10

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cites work (P2860)
Q90622160Bacterial cell cycle and growth phase switch by the essential transcriptional regulator CtrA
Q90411042The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of 'Long' RelA-SpoT Homolog Enzymes by Ribosomal Complexes

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