Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway

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Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/EMM.2017.158
P932PMC publication ID5992985
P698PubMed publication ID29303510

P50authorAntonio CiglianoQ43122575
P2093author name stringXin Chen
Meng Xu
Diego F Calvisi
Hui Cao
Frank Dombrowski
Zhong Xu
Silvia Ribback
Junjie Hu
Maria G Pilo
Zixuan Shao
P2860cites workMultiplex genome engineering using CRISPR/Cas systemsQ24609428
mTOR signaling in growth control and diseaseQ24634174
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The mTOR pathway is associated with the poor prognosis of human hepatocellular carcinomaQ46081339
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC.Q53347351
Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinomaQ81128776
The critical role of AKT2 in hepatic steatosis induced by PTEN lossQ33816356
Synergistic role of sprouty2 inactivation and c-Met up-regulation in mouse and human hepatocarcinogenesisQ34062598
IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage.Q34102411
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1cQ34269920
CRISPR-mediated direct mutation of cancer genes in the mouse liverQ34353586
Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotypeQ34619635
Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: the EVOLVE-1 randomized clinical trialQ34663499
Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.Q34672477
c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinomaQ35235798
In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.Q35250612
SKP2 cooperates with N-Ras or AKT to induce liver tumor development in miceQ35273519
Distinct pathways of genomic progression to benign and malignant tumors of the liver.Q35970966
Targeting the HGF/c-MET Pathway in Hepatocellular CarcinomaQ36093497
Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppressionQ36248716
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesisQ36384467
Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice.Q36560210
Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans.Q36922232
Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms.Q37038522
Role of cyclin D1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesisQ37065772
Pivotal role of mTOR signaling in hepatocellular carcinomaQ37183244
Pathogenesis of hepatocellular carcinoma and molecular therapies.Q37456002
Akt-mediated foxo1 inhibition is required for liver regeneration.Q37525730
Potentiation of the anticancer effects of everolimus using a dual mTORC1/2 inhibitor in hepatocellular carcinoma cellsQ37709404
PTEN in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis and cancer.Q37749362
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Hydrodynamic transfection for generation of novel mouse models for liver cancer researchQ38183539
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.Q38534459
Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trialQ38785510
Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humansQ38827148
mTORC1 and mTORC2 in cancer and the tumor microenvironmentQ38982579
Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2.Q39656536
Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascadeQ42468960
Expression and prognostic role of tumor suppressor gene PTEN/MMAC1/TEP1 in hepatocellular carcinomaQ43049041
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P304page(s)e417
P577publication date2018-01-05
P1433published inExperimental and Molecular MedicineQ15758292
P1476titleLoss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway
P478volume50

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cites work (P2860)
Q91857825Activated Fibroblast Program Orchestrates Tumor Initiation and Progression; Molecular Mechanisms and the Associated Therapeutic Strategies
Q92898129Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans
Q90383817Experimental Models to Define the Genetic Predisposition to Liver Cancer
Q64053269Functional role of SGK3 in PI3K/Pten driven liver tumor development
Q58612842Genomic Medicine and Implications for Hepatocellular Carcinoma Prevention and Therapy
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Q58693431Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular Carcinoma
Q89861316Molecular Signaling Pathways and Therapeutic Targets in Hepatocellular Carcinoma
Q92192093Molecular links between non-alcoholic fatty liver disease and hepatocellular carcinoma
Q89531796Oncogene-dependent function of BRG1 in hepatocarcinogenesis
Q94566583Role of the mTOR pathway in liver cancer: from molecular genetics to targeted therapies
Q90240699Validation of miR-20a as a Tumor Suppressor Gene in Liver Carcinoma Using Hepatocyte-Specific Hyperactive piggyBac Transposons

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