Effects of dietary RRR α-tocopherol vs all-racemic α-tocopherol on health outcomes

scientific article published on 29 December 2017

Effects of dietary RRR α-tocopherol vs all-racemic α-tocopherol on health outcomes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NUTRIT/NUX067
P698PubMed publication ID29301023

P2093author name stringJohn W Erdman
Katherine M Ranard
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
A novel human tocopherol-associated protein: cloning, in vitro expression, and characterizationQ22254156
Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesisQ24290876
Tocopherol-associated protein is a ligand-dependent transcriptional activatorQ24291424
Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysisQ24569500
Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trialQ24654699
Options for basing Dietary Reference Intakes (DRIs) on chronic disease endpoints: report from a joint US-/Canadian-sponsored working groupQ28076931
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardicoQ28143207
Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trialQ28182767
Ligand specificity in the CRAL-TRIO protein familyQ28206484
Alpha-tocopherol stereoisomersQ28236428
Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin EQ28344980
Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trialQ30584897
Long-term vitamin E supplementation reduces atherosclerosis and mortality in Ldlr-/- mice, but not when fed Western style dietQ33637932
d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant propertiesQ33654586
Cancer-preventive activities of tocopherols and tocotrienolsQ33814811
Vitamin E and age-related macular degeneration in a randomized trial of womenQ33895488
Bioavailability and potency of natural-source and all-racemic alpha-tocopherol in the human: a disputeQ33929259
Delayed-onset ataxia in mice lacking alpha -tocopherol transfer protein: model for neuronal degeneration caused by chronic oxidative stressQ33953020
MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trialQ33960122
Brain tocopherols related to Alzheimer's disease neuropathology in humansQ34105575
α-Tocopherol supplementation of allergic female mice inhibits development of CD11c+CD11b+ dendritic cells in utero and allergic inflammation in neonates.Q34201241
Vitamin E inadequacy in humans: causes and consequencesQ34300143
Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer proteinQ34308654
Vitamin E consumption and the risk of coronary heart disease in men.Q34363912
Plasma nutrient status of patients with Alzheimer's disease: Systematic review and meta-analysisQ34379154
Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trialQ34403303
Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trialQ34424586
Dietary cosupplementation with vitamin E and coenzyme Q(10) inhibits atherosclerosis in apolipoprotein E gene knockout miceQ43576465
Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community studyQ44036291
Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS).Q44138520
Vitamin C and vitamin E supplement use and bladder cancer mortality in a large cohort of US men and womenQ44225820
A randomized trial of vitamin E supplementation and cognitive function in womenQ44853596
Effects of alpha-tocopherol on an animal model of tauopathiesQ44941231
Supplemental and dietary vitamin E intakes and risk of prostate cancer in a large prospective studyQ45067083
Alpha-tocopherol transfer protein deficiency in mice causes multi-organ deregulation of gene networks and behavioral deficits with age.Q45308919
Vitamin E supplementation increases T helper 1 cytokine production in old mice infected with influenza virusQ45741191
Differential effects of natural and synthetic vitamin E on gene transcription in murine T lymphocytesQ46076047
Dietary vitamin E, brain redox status and expression of Alzheimer's disease-relevant genes in rats.Q46144137
Plasma concentrations of dietary and nondietary antioxidants are low in severe asthmaQ46628219
Effects on neural function of repleting vitamin E-deficient rats with alpha-tocopherolQ46880162
Apolipoprotein E genotype and alpha-tocopherol modulate amyloid precursor protein metabolism and cell cycle regulationQ46887821
Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adultsQ46984811
Pre-treatment and post-treatment with alpha-tocopherol attenuates hippocampal neuronal damage in experimental cerebral hypoperfusionQ48123425
Localization of alpha-tocopherol transfer protein in the brains of patients with ataxia with vitamin E deficiency and other oxidative stress related neurodegenerative disordersQ48259283
Localization of alpha-tocopherol transfer protein in rat brainQ48327681
Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial.Q48362689
Deletion of vitamin E enhances phenotype of Alzheimer disease model mouseQ48402489
Dietary supplementation with vitamin E reverses the age-related deficit in long term potentiation in dentate gyrusQ48445068
A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative StudyQ48725577
Supplementation with RRR- or all-rac-α-Tocopherol Differentially Affects the α-Tocopherol Stereoisomer Profile in the Milk and Plasma of Lactating WomenQ48786855
Vitamin E consumption and the risk of coronary disease in womenQ50126258
Dietary vitamin E modulates differential gene expression in the rat hippocampus: potential implications for its neuroprotective properties.Q51592809
Dietary intake of selected micronutrients and the risk of pancreatic cancer: an Italian case-control study.Q51612338
Effects of oral micellized natural vitamin E (D-α-tocopherol) v. synthetic vitamin E (DL-α-tocopherol) in feed on α-tocopherol levels, stereoisomer distribution, oxidative stress and the immune response in piglets.Q51752749
Post-seizure α-tocopherol treatment decreases neuroinflammation and neuronal degeneration induced by status epilepticus in rat hippocampus.Q51755394
Age and vitamin E-induced changes in gene expression profiles of T cells.Q51978313
Protective effect of vitamin E supplements on experimental atherosclerosis is modest and depends on preexisting vitamin E deficiency.Q52572721
The role of vitamin E (tocopherol) supplementation in the prevention of stroke. A meta-analysis of 13 randomised controlled trials.Q55053893
Synthetic as compared with natural vitamin E is preferentially excreted as α-CEHC in human urine: studies using deuterated α-tocopheryl acetatesQ58320370
Treatment of ataxia in isolated vitamin E deficiency caused by alpha-tocopherol transfer protein deficiencyQ34490885
Supplemental and dietary vitamin E, beta-carotene, and vitamin C intakes and prostate cancer riskQ34494587
Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trialQ34601546
Dose-response comparison of RRR-alpha-tocopherol and all-racemic alpha-tocopherol on LDL oxidationQ34743416
Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trialQ35031127
Effects of supplementation with the fat-soluble vitamins E and D on fasting flow-mediated vasodilation in adults: a meta-analysis of randomized controlled trialsQ35227875
Vitamin E supplements in asthma: a parallel group randomised placebo controlled trialQ35536924
Re-evaluation of the relative potency of synthetic and natural alpha-tocopherol: experimental and clinical observationsQ35818783
Human plasma vitamin E kinetics demonstrate rapid recycling of plasma RRR-alpha-tocopherolQ35827647
Vitamin E supplementation and the risk of heart failure in womenQ35848591
Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studiesQ36223045
α-Tocopherol bioavailability is lower in adults with metabolic syndrome regardless of dairy fat co-ingestion: a randomized, double-blind, crossover trialQ36223074
Natural-source d-α-tocopheryl acetate inhibits oxidant stress and modulates atopic asthma in humans in vivoQ36333290
This kinetic, bioavailability, and metabolism study of RRR-α-tocopherol in healthy adults suggests lower intake requirements than previous estimatesQ36398641
Vitamin E biokinetics, oxidative stress and cigarette smokingQ36524820
Age-associated changes in immune and inflammatory responses: impact of vitamin E interventionQ36882253
Two faces of vitamin E in the lungQ37186942
Vitamin E reverses impaired linker for activation of T cells activation in T cells from aged C57BL/6 miceQ37271492
Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP(-/-)).Q37316075
The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endotheliumQ37358390
Severe vitamin E deficiency modulates airway allergic inflammatory responses in the murine asthma modelQ37404698
Genome wide responses of murine lungs to dietary alpha-tocopherolQ37435901
Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer diseaseQ37446178
Vitamin E is essential for Purkinje neuron integrityQ37618797
Oxidative stress and oxidative damage in carcinogenesisQ37658133
Dietary alpha-tocopherol and neuromuscular health: search for optimal dose and molecular mechanisms continues!Q37699167
The vitamin E isoforms α-tocopherol and γ-tocopherol have opposite associations with spirometric parameters: the CARDIA studyQ37730799
Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer proteinQ38347471
Vitamin E and neurodegenerationQ38442623
The naturally occurring α-tocopherol stereoisomer RRR-α-tocopherol is predominant in the human infant brainQ39764577
High dosage of ascorbic acid and alpha-tocopherol is not useful for diminishing oxidative stress and DNA damage in healthy elderly adultsQ39844722
Characterization of three human sec14p-like proteins: alpha-tocopherol transport activity and expression pattern in tissuesQ39947480
Alpha-tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activityQ41689122
Effects of maternal natural (RRR alpha-tocopherol acetate) or synthetic (all-rac alpha-tocopherol acetate) vitamin E supplementation on suckling calf performance, colostrum immunoglobulin G, and immune functionQ43056297
alpha-Tocopherol concentrations in equine serum and cerebrospinal fluid after vitamin E supplementationQ43122760
P577publication date2017-12-29
P1433published inNutrition ReviewsQ15765213
P1476titleEffects of dietary RRR α-tocopherol vs all-racemic α-tocopherol on health outcomes