STAT1 activation by venous malformations mutant Tie2-R849W antagonizes VEGF-A-mediated angiogenic response partly via reduced bFGF production

scientific article published on 21 October 2012

STAT1 activation by venous malformations mutant Tie2-R849W antagonizes VEGF-A-mediated angiogenic response partly via reduced bFGF production is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S10456-012-9313-X
P698PubMed publication ID23086340
P5875ResearchGate publication ID232533509

P2093author name stringShin-Chen Pan
Wu-Chou Su
Yi-Wen Chen
Li-Wha Wu
Ming-Ping Wu
Yi-Hsien Huang
P2860cites workVEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling.Q42824102
Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesisQ43276960
Vascular endothelial growth factor increases the migration and proliferation of smooth muscle cells through the mediation of growth factors released by endothelial cellsQ44319020
Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cellsQ44802860
Isolation and culture of arterial smooth muscle cells from human placentaQ44900670
Alternative activation of STAT1 and STAT3 in response to interferon-gammaQ45000443
Functional analysis of a mutant form of the receptor tyrosine kinase Tie2 causing venous malformations.Q45138923
VEGF regulates FGF-2 and TGF-beta1 expression in injury endothelial cells and mediates smooth muscle cells proliferation and migrationQ46063173
Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formationQ47745076
Activation of stat3 in human melanoma promotes brain metastasisQ48616814
bFGF and LIF signaling activates STAT3 in proliferating myoblastsQ50113529
Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalizationQ50335796
Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2Q24310216
Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesisQ24313413
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formationQ24316945
Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expressionQ24619748
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylationQ28288257
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesisQ28300359
Angiopoietin and Tie signaling pathways in vascular developmentQ28640803
Molecular regulation of vessel maturationQ29614540
Vascular-specific growth factors and blood vessel formationQ29614780
Hereditary cutaneomucosal venous malformations are caused by TIE2 mutations with widely variable hyper-phosphorylating effectsQ33739356
Angiogenesis in embryonic development--a reviewQ33930024
Mutational switch of an IL-6 response to an interferon-gamma-like responseQ34031049
The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signallingQ34123640
Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway.Q34132787
Molecular mechanisms of blood vessel growthQ34134535
The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development.Q34611010
Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cellsQ35848595
Angiogenesis: now and then.Q35962594
Role of STAT-1 and STAT-3 in ischaemia/reperfusion injury.Q35985573
Opposing actions of STAT-1 and STAT-3.Q36294468
Endothelial cells and VEGF in vascular developmentQ36342350
STAT3: a critical transcription activator in angiogenesis.Q36801186
STAT1 and STAT3 as intracellular regulators of vascular remodelingQ36851312
Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformationsQ37163303
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesisQ38290076
STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytesQ38311269
Tie2-R849W mutant in venous malformations chronically activates a functional STAT1 to modulate gene expressionQ39993471
Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion.Q40308418
STAT1-induced apoptosis is mediated by caspases 2, 3, and 7.Q40615732
Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation responseQ40976813
Nox1 mediates basic fibroblast growth factor-induced migration of vascular smooth muscle cells.Q42513515
Angiopoietin-1 and its receptor Tie-2 participate in the regulation of capillary-like tubule formation and survival of endothelial cellsQ42809627
P433issue1
P304page(s)207-222
P577publication date2012-10-21
P1433published inAngiogenesisQ15753544
P1476titleSTAT1 activation by venous malformations mutant Tie2-R849W antagonizes VEGF-A-mediated angiogenic response partly via reduced bFGF production
P478volume16

Reverse relations

cites work (P2860)
Q92882879Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte Recruitment
Q33807944Disorganized vascular structures in sporadic venous malformations: a possible correlation with balancing effect between Tie2 and TGF-β.
Q50292659Expression of STAT3-upregulated extracellular proteins
Q59333069Galiellalactone inhibits the STAT3/AR signaling axis and suppresses Enzalutamide-resistant Prostate Cancer
Q27333126Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects
Q38205362STAT3 Target Genes Relevant to Human Cancers
Q34831579STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models
Q50420605Transgenic Expression of A Venous Malformation Related Mutation, TIE2-R849W, Significantly Induces Multiple Malformations of Zebrafish
Q37078845Venous malformation-causative TIE2 mutations mediate an AKT-dependent decrease in PDGFB.
Q38706087miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin

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