Highly facile and regio-selective synthesis of pyrazolo[1,5-a]pyrimidines via reactions of 1,2-allenic ketones with aminopyrazoles

scientific article published on 20 February 2014

Highly facile and regio-selective synthesis of pyrazolo[1,5-a]pyrimidines via reactions of 1,2-allenic ketones with aminopyrazoles is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1039/C3OB42445F
P698PubMed publication ID24553740

P2093author name stringLin Gao
Xinying Zhang
Xuesen Fan
Xiaojie Guo
Yunping Song
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Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activityQ34366746
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Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imagingQ34632108
5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activityQ34676027
Parallel synthesis of 7-heteroaryl-pyrazolo[1,5-a]pyrimidine-3-carboxamidesQ34969798
Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structureQ34984243
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Synthesis of pyrazolo[1,5-a]pyrimidine linked aminobenzothiazole conjugates as potential anticancer agents.Q39159646
Mechanistic insights into the gold-catalyzed cycloisomerization of bromoallenyl ketones: ligand-controlled regioselectivityQ39407417
Practical and efficient synthesis of pyrano[3,2-c]pyridone, pyrano[4,3-b]pyran and their hybrids with nucleoside as potential antiviral and antileishmanial agentsQ39753559
Adenosine cyclic 3',5'-monophosphate phosphodiesterase inhibitors. 2. 3-Substituted 5,7-dialkylpyrazolo[1,5-a]pyrimidinesQ39943995
A novel selective GABA(A) alpha1 receptor agonist displaying sedative and anxiolytic-like properties in rodents.Q40362720
Synthesis and SAR of a new series of COX-2-selective inhibitors: pyrazolo[1,5-a]pyrimidines.Q40791298
The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1 ,5-a]-pyrimidine: a corticotropin-releasing factor (hCRF1) antagonistQ40857636
Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitorQ42714215
Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.Q42725692
Synthesis and antimicrobial activity of some new thiazole, thiophene and pyrazole derivatives containing benzothiazole moietyQ42982374
Cross-coupling/cyclization reactions of two different allenic moietiesQ43085650
Ionic liquid mediated and promoted eco-friendly preparation of thiazolidinone and pyrimidine nucleoside-thiazolidinone hybrids and their antiparasitic activitiesQ43263893
Synthesis and initial SAR studies of 3,6-disubstituted pyrazolo[1,5-a]pyrimidines: a new class of KDR kinase inhibitorsQ44128998
Resourceful synthesis of pyrazolo[1,5-a]pyrimidines under ultrasound irradiationQ44697389
Synthesis, antibacterial activity and cytotoxicity of new fused pyrazolo[1,5-a]pyrimidine and pyrazolo[5,1-c][1,2,4]triazine derivatives from new 5-aminopyrazolesQ45741475
Synthesis and anti-tumor activities of some new pyridines and pyrazolo[1,5-a]pyrimidines.Q46034720
Tandem reactions of 1,2-allenic ketones leading to substituted benzenes and α,β-unsaturated nitriles.Q50513457
Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists.Q53792247
Simple approach to the synthesis of 3-fluoro pyrazolo[1,5-a]pyrimidine analoguesQ57082289
P433issue13
P304page(s)2099-2107
P577publication date2014-02-20
P1433published inOrganic and Biomolecular ChemistryQ3355939
P1476titleHighly facile and regio-selective synthesis of pyrazolo[1,5-a]pyrimidines via reactions of 1,2-allenic ketones with aminopyrazoles
P478volume12

Reverse relations

cites work (P2860)
Q47623807A convenient synthesis of 1-aryl-1H-1,2,3-triazoles from aliphatic substrates
Q50972013A facile environment-friendly one-pot two-step regioselective synthetic strategy for 3,7-diarylpyrazolo[1,5-a]pyrimidines related to zaleplon and 3,6-diarylpyrazolo[1,5-a]pyrimidine-7-amines assisted by KHSO[Formula: see text] in aqueous media.
Q53302433A facile, regioselective synthesis of novel 3-(N-phenylcarboxamide)pyrazolo[1,5-a]pyrimidine analogs in the presence of KHSO4 in aqueous media assisted by ultrasound and their antibacterial activities.
Q89701659An efficient and targeted synthetic approach towards new highly substituted 6-amino-pyrazolo[1,5-a]pyrimidines with α-glucosidase inhibitory activity
Q50227293Recent Advances in the Reactions of 1,2-Allenic Ketones and α-Allenic Alcohols

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