Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging

scientific article

Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/JM4001874
P932PMC publication ID3648642
P698PubMed publication ID23521048

P50authorMd Imam UddinQ42783120
P2093author name stringJason R Buck
H Charles Manning
Eliot T McKinley
Joel M Harp
Dewei Tang
Allie Fu
Michael L Nickels
Matthew R Hight
P2860cites work2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands.Q43737788
Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammationQ46119208
Synthesis and in vivo evaluation of a novel peripheral benzodiazepine receptor PET radioligandQ46614777
Halogenated 4-(phenoxymethyl)piperidines as potential radiolabeled probes for sigma-1 receptors: in vivo evaluation of [123I]-1-(iodopropen-2-yl)-4-[(4-cyanophenoxy)methyl]pip eri dineQ48705414
Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammationQ80140819
Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular functionQ24296269
Regulation of translocator protein 18 kDa (TSPO) expression in health and disease statesQ24631648
PET radiotracers: crossing the blood-brain barrier and surviving metabolismQ33585028
Microwave-assisted Organic Synthesis of a High-affinity Pyrazolo-pyrimidinyl TSPO LigandQ33650978
Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammationQ34171364
Biodistribution and radiation dosimetry in humans of a new PET ligand, (18)F-PBR06, to image translocator protein (18 kDa).Q34382894
Quantitative, preclinical PET of translocator protein expression in glioma using 18F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyanilineQ34522608
Quantitative preclinical imaging of TSPO expression in glioma using N,N-diethyl-2-(2-(4-(2-18F-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide.Q36081687
Structural requirements to obtain highly potent and selective 18 kDa Translocator Protein (TSPO) Ligands.Q37835335
Molecular imaging of the translocator protein (TSPO) in a pre-clinical model of breast cancerQ39769015
Targeted molecular imaging agents for cellular-scale bimodal imagingQ40491443
[11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitisQ41863477
Evaluation of the PBR/TSPO radioligand [(18)F]DPA-714 in a rat model of focal cerebral ischemiaQ42414802
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)3429-3433
P577publication date2013-04-03
P1433published inJournal of Medicinal ChemistryQ900316
P1476titleSynthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging
P478volume56

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