Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming.

scientific article published on 26 May 2013

Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NCB2765
P698PubMed publication ID23708003
P5875ResearchGate publication ID236939150

P50authorDuanqing PeiQ5310422
Hui ZhengQ42716126
Jiekai ChenQ42761792
Guangjin PanQ95964169
Chengqian FengQ117269551
Yunqian GuoQ117269552
Dajiang QinQ117269554
P2093author name stringWen Li
Jing Liu
Hao Sun
Linli Wang
Jing Qi
Songwei He
Xiaopeng Liu
Chunlan Chen
P2860cites workEvidence for mesenchymal-epithelial transition associated with mouse hepatic stem cell differentiationQ21135539
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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsQ27860937
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.Q28131663
Promotion of reprogramming to ground state pluripotency by signal inhibitionQ28473911
Mechanisms and functional implications of adult neurogenesisQ29547295
Generation of mouse induced pluripotent stem cells without viral vectorsQ29614342
Immunogenicity of induced pluripotent stem cellsQ29616185
Generation of induced pluripotent stem cells using recombinant proteinsQ29619162
A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanogQ33509682
Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: roles of transforming growth factor (TGF)-beta and bone morphogenetic protein (BMP).Q33823445
Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expressionQ34030950
Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genomeQ34034406
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblastsQ34125363
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogrammingQ34125369
Critical and reciprocal regulation of KLF4 and SLUG in transforming growth factor β-initiated prostate cancer epithelial-mesenchymal transitionQ34243311
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phaseQ34299819
Mesenchymal-epithelial transition during somitic segmentation is regulated by differential roles of Cdc42 and Rac1.Q34347783
Mesenchyme to epithelium transition during development of the mammalian kidney tubuleQ34423679
Transitions between epithelial and mesenchymal states in development and diseaseQ34761972
Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologueQ35227331
Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kineticsQ35469739
Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cellsQ35947171
Reprogramming of murine and human somatic cells using a single polycistronic vectorQ37068363
Mouse meningiocytes express Sox2 and yield high efficiency of chimeras after nuclear reprogramming with exogenous factorsQ37142823
Role of the epithelial-mesenchymal transition regulator Slug in primary human cancersQ37410395
Induced pluripotent stem cells: developmental biology to regenerative medicineQ37801268
MET signalling: principles and functions in development, organ regeneration and cancerQ37811895
The EMT regulator slug and lung carcinogenesisQ37888326
Transcriptional activation of ZEB1 by Slug leads to cooperative regulation of the epithelial-mesenchymal transition-like phenotype in melanomaQ38587374
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCsQ39234437
Copy number variation and selection during reprogramming to pluripotencyQ39582693
A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identityQ39618673
Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation.Q39619885
Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition.Q40457821
A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancerQ42522113
Vitamin C enhances the generation of mouse and human induced pluripotent stem cellsQ43207059
Generation of induced pluripotent stem cells from adult rhesus monkey fibroblastsQ47209086
The challenge of immunogenicity in the quest for induced pluripotency.Q51776242
The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner.Q53204519
A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewalQ56067490
Generation of induced pluripotent stem cell lines from adult rat cellsQ83039078
Vitamin C improves the quality of somatic cell reprogrammingQ83761829
Expression of the E-cadherin repressors Snail, Slug and Zeb1 in urothelial carcinoma of the urinary bladder: relation to stromal fibroblast activation and invasive behaviour of carcinoma cellsQ84596555
Thrombin induces slug-mediated E-cadherin transcriptional repression and the parallel up-regulation of N-cadherin by a transcription-independent mechanism in RPE cellsQ84623878
P433issue7
P304page(s)829-838
P577publication date2013-05-26
P1433published inNature Cell BiologyQ1574111
P1476titleSequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming.
P478volume15

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