Salvianolic acid B inhibits hepatic stellate cell activation through transforming growth factor beta-1 signal transduction pathway in vivo and in vitro.

scientific article published on 4 September 2013

Salvianolic acid B inhibits hepatic stellate cell activation through transforming growth factor beta-1 signal transduction pathway in vivo and in vitro. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1177/1535370213498979
P698PubMed publication ID24006304

P2093author name stringLi Shen
Cheng-Hai Liu
Yan-Yan Tao
Wen-Wei Fu
Qing-Lan Wang
P2860cites workCloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptorQ28507865
Effects of salvianolic acid B on expressions of TGF-beta1 and its receptors in liver of rats with dimethylnitrosamine-induced hepatic fibrosisQ28566912
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liverQ29616840
A solid-phase extraction method for high-performance liquid chromatographic determination of salvianolic acid B in rabbit plasma: application to pharmacokinetic studyQ33269113
Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injuryQ33822590
Salvianolic Acid B Inhibits ERK and p38 MAPK Signaling in TGF-β1-Stimulated Human Hepatic Stellate Cell Line (LX-2) via Distinct PathwaysQ35163498
Hepatic fibrosis: molecular mechanisms and drug targetsQ35911848
Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B.Q36308206
Salvianolic Acid B Attenuates Rat Hepatic Fibrosis via Downregulating Angiotensin II SignalingQ36456025
Effects of Fuzheng Huayu 319 recipe on liver fibrosis in chronic hepatitis B.Q36601226
Hepatic fibrosis -- overviewQ37228945
Effect of Fuzheng Huayu formula and its actions against liver fibrosisQ37289563
Pathogenesis of liver fibrosisQ37809079
TGF-β/TGF-β receptor system and its role in physiological and pathological conditions.Q37880150
Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta ) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent.Q38358348
Effect of salvianolic-acid B on inhibiting MAPK signaling induced by transforming growth factor-β1 in activated rat hepatic stellate cellsQ39685359
Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activationQ40728276
C. L. Oakley Lecture (1993). Cellular and molecular aspects of hepatic fibrosis.Q40831781
Liver injury related to amoxycillin-clavulanic acid: interlobular bile-duct lesions and extrahepatic manifestationsQ42279177
Gene expression of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine in the rat.Q42856019
Therapeutic efficacy of Traditional Chinese Medicine 319 recipe on hepatic fibrosis induced by carbon tetrachloride in rats.Q45980038
In vitro protective effects of salvianolic acid B on primary hepatocytes and hepatic stellate cellsQ46824760
P433issue11
P304page(s)1284-1296
P577publication date2013-09-04
P1433published inExperimental Biology and MedicineQ15716535
P1476titleSalvianolic acid B inhibits hepatic stellate cell activation through transforming growth factor beta-1 signal transduction pathway in vivo and in vitro.
P478volume238

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cites work (P2860)
Q38588143A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives
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Q38326327Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis
Q50055024Salvianolate reduces glucose metabolism disorders in dimethylnitrosamine-induced cirrhotic rats
Q37039390Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3K/Akt/Nrf2 Pathway
Q53634280Salvianolic Acid B Protects Normal Human Dermal Fibroblasts Against Ultraviolet B Irradiation-Induced Photoaging Through Mitogen-Activated Protein Kinase and Activator Protein-1 Pathways.
Q64229967Salvianolic Acids: Potential Source of Natural Drugs for the Treatment of Fibrosis Disease and Cancer
Q41520562Salvianolic acid B regulates gene expression and promotes cell viability in chondrocytes
Q36232847Salvianolic acid B-induced microRNA-152 inhibits liver fibrosis by attenuating DNMT1-mediated Patched1 methylation.
Q47334982Simvastatin augments activation of liver regeneration through attenuating transforming growth factor-β1 induced-apoptosis in obstructive jaundice rats
Q38257833Traditional Chinese medicine for treatment of liver diseases: progress, challenges and opportunities

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