NG2 regulates directional migration of oligodendrocyte precursor cells via Rho GTPases and polarity complex proteins.

scientific article published in June 2013

NG2 regulates directional migration of oligodendrocyte precursor cells via Rho GTPases and polarity complex proteins. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.5010-12.2013
P932PMC publication ID6618486
P698PubMed publication ID23804106

P50authorDominik SakryQ52145536
Valérie JolivelQ59664342
Leda DimouQ96223416
P2093author name stringJacqueline Trotter
Fabien Binamé
P2860cites workMelanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130casQ22010904
The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs LostQ24293049
The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2Q24609951
CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cellsQ24632780
Intracellular localization of the P21rho proteinsQ24642838
RHGF-2 is an essential Rho-1 specific RhoGEF that binds to the multi-PDZ domain scaffold protein MPZ-1 in Caenorhabditis elegansQ27308965
Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowthQ28201468
The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signalingQ28216364
Regulation of ezrin localization by Rac1 and PIPK in human epithelial cellsQ28283727
Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motilityQ28289670
The mystery and magic of glia: a perspective on their roles in health and diseaseQ28300305
Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cellsQ28504854
The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cellsQ28505865
A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotypeQ28507258
Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzetaQ28583531
Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylationQ28590637
Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelinationQ28591752
Cell-surface glycoprotein of oligodendrocyte progenitors involved in migrationQ28592563
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factorsQ29547630
Random versus directionally persistent cell migrationQ29616686
Rho GTPases and cell migrationQ29616714
Coordination of Rho GTPase activities during cell protrusionQ29618432
Spatiotemporal dynamics of RhoA activity in migrating cellsQ29618433
Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migrationQ30433120
The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPaseQ30438135
Localized RhoA activation as a requirement for the induction of membrane rufflingQ30476117
Transforming growth factor beta controls the directional migration of hepatocyte cohorts by modulating their adhesion to fibronectin.Q30481397
The NG2 proteoglycan promotes oligodendrocyte progenitor proliferation and developmental myelinationQ33761196
The inhibitory effects of chondroitin sulfate proteoglycans on oligodendrocytesQ34208617
Generation of truncated forms of the NG2 proteoglycan by cell surface proteolysisQ34454342
Progeny of Olig2-expressing progenitors in the gray and white matter of the adult mouse cerebral cortex.Q34848711
Contact inhibition of locomotion in vivo controls neural crest directional migrationQ34902880
Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticityQ34908170
RhoA and RhoC have distinct roles in migration and invasion by acting through different targetsQ35196063
Roles of Rho-family GTPases in cell polarisation and directional migrationQ35547373
Reduced inflammation accompanies diminished myelin damage and repair in the NG2 null mouse spinal cord.Q35588967
PATJ regulates directional migration of mammalian epithelial cellsQ35632826
Asymmetry-defective oligodendrocyte progenitors are glioma precursorsQ35814886
Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system developmentQ36118630
Differential phosphorylation of NG2 proteoglycan by ERK and PKCalpha helps balance cell proliferation and migrationQ36118785
Mechanism and role of localized activation of Rho-family GTPases in growth factor-stimulated fibroblasts and neuronal cells.Q36206370
A Rac switch regulates random versus directionally persistent cell migrationQ36320639
Neuron-glia communication in the control of oligodendrocyte function and myelin biogenesisQ36639361
Crosstalk between small GTPases and polarity proteins in cell polarization.Q37306478
Polarity proteins in migration and invasionQ37333610
A role for the NG2 proteoglycan in glioma progressionQ37406681
Role of the oligodendroglial cytoskeleton in differentiation and myelinationQ37489705
Rho and Ras GTPases in axon growth, guidance, and branchingQ37698277
What makes cells move: requirements and obstacles for spontaneous cell motility.Q37710995
Functional and Clinical Relevance of Chondroitin Sulfate Proteoglycan 4Q37808799
The stem cell potential of glia: lessons from reactive gliosisQ37830315
Postnatal neurogenesis and gliogenesis in the olfactory bulb from NG2-expressing progenitors of the subventricular zone.Q38334176
Control of neurite outgrowth by RhoA inactivationQ38469173
Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactionsQ39393613
Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectorsQ39588446
FGF-2 and Anosmin-1 are selectively expressed in different types of multiple sclerosis lesions.Q39695167
Specific induction of migration and invasion of pancreatic carcinoma cells by RhoC, which differs from RhoA in its localisation and activityQ39818884
Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins.Q39877904
The neuronal RhoA GEF, Tech, interacts with the synaptic multi-PDZ-domain-containing protein, MUPP1.Q39974418
N-WASP regulates extension of filopodia and processes by oligodendrocyte progenitors, oligodendrocytes, and Schwann cells-implications for axon ensheathment at myelinationQ40150333
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.Q40456149
The Rac exchange factor Tiam1 is required for the establishment and maintenance of cadherin-based adhesionsQ40557093
Biosensors for characterizing the dynamics of rho family GTPases in living cellsQ41177591
Lines of murine oligodendroglial precursor cells immortalized by an activated neu tyrosine kinase show distinct degrees of interaction with axons in vitro and in vivo.Q41341474
Rho- and rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: an essential role for ezrin/radixin/moesin proteinsQ42796333
p85 beta-PIX is required for cell motility through phosphorylations of focal adhesion kinase and p38 MAP kinaseQ42814734
A local coupling model and compass parameter for eukaryotic chemotaxis.Q42818498
Chondroitin sulfate and cytoplasmic domain-dependent membrane targeting of the NG2 proteoglycan promotes retraction fiber formation and cell polarization.Q43700324
Signaling from integrins to Fyn to Rho family GTPases regulates morphologic differentiation of oligodendrocytes.Q44684981
NG2 proteoglycan-expressing cells of the adult rat brain: possible involvement in the formation of glial scar astrocytes following stab woundQ45115534
NG2-expressing cells in the nervous system revealed by the NG2-EYFP-knockin mouseQ46314223
In vitro assay of primary astrocyte migration as a tool to study Rho GTPase function in cell polarization.Q46940023
Roles of STEF/Tiam1, guanine nucleotide exchange factors for Rac1, in regulation of growth cone morphology.Q47450289
Tenascin C and tenascin R similarly prevent the formation of myelin membranes in a RhoA-dependent manner, but antagonistically regulate the expression of myelin basic protein via a separate pathwayQ47752933
Monoclonal antibodies against myelin proteolipid protein: identification and characterization of two major determinantsQ48635003
Analysis of cell migration and its regulation by Rho GTPases and p53 in a three-dimensional environment.Q50640570
A functional role for EGFR signaling in myelination and remyelination.Q50674097
The apical polarity determinant Crumbs 2 is a novel regulator of ESC-derived neural progenitors.Q54576271
Progenitors in the adult cerebral cortex: Cell cycle properties and regulation by physiological stimuli and injuryQ57031628
Interaction of Syntenin-1 and the NG2 Proteoglycan in Migratory Oligodendrocyte Precursor CellsQ57957953
Oligodendrocytes Direct Glycosyl Phosphatidylinositol-anchored Proteins to the Myelin Sheath in Glycosphingolipid-rich ComplexesQ57980238
RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathwayQ73694339
Dissociation of LPA-induced cytoskeletal contraction from stress fiber formation by differential localization of RhoAQ73970772
Guidance of glial precursor cell migration by secreted cues in the developing optic nerveQ74485535
Different roles for RhoA during neurite initiation, elongation, and regeneration in PC12 cellsQ78170170
Engagement of the NG2 proteoglycan triggers cell spreading via rac and p130casQ78431424
A role for the polysialic acid-neural cell adhesion molecule in PDGF-induced chemotaxis of oligodendrocyte precursor cellsQ79307968
Responses of reactive astrocytes containing S100beta protein and fibroblast growth factor-2 in the border and in the adjacent preserved tissue after a contusion injury of the spinal cord in rats: implications for wound repair and neuroregenerationQ79629953
P4510describes a project that usesImageJQ1659584
P433issue26
P407language of work or nameEnglishQ1860
P921main subjectoligodendrocyteQ916698
P304page(s)10858-10874
P577publication date2013-06-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleNG2 regulates directional migration of oligodendrocyte precursor cells via Rho GTPases and polarity complex proteins
P478volume33

Reverse relations

cites work (P2860)
Q35910607A new in vitro mouse oligodendrocyte precursor cell migration assay reveals a role for integrin-linked kinase in cell motility
Q52570583ASCL1 regulates proliferation of NG2-glia in the embryonic and adult spinal cord.
Q50668972Age-related differences in oligodendrogenesis across the dorsal-ventral axis of the mouse hippocampus.
Q38761387Basic fibroblast growth factor promotes melanocyte migration via activating PI3K/Akt-Rac1-FAK-JNK and ERK signaling pathways
Q51762402Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities.
Q93370002Cognitive deficits in mice lacking Nsun5, a cytosine-5 RNA methyltransferase, with impairment of oligodendrocyte precursor cells
Q48482418Critical role of Ror2 receptor tyrosine kinase in regulating cell cycle progression of reactive astrocytes following brain injury
Q46621500ERK1/2 signaling is essential for the chemoattraction exerted by human FGF2 and human anosmin-1 on newborn rat and mouse OPCs via FGFR1.
Q53020934Early phenotypic asymmetry of sister oligodendrocyte progenitor cells after mitosis and its modulation by aging and extrinsic factors.
Q33980507Establishment of epithelial polarity--GEF who's minding the GAP?
Q35323930Expression of polarity genes in human cancer
Q64963645Glial Cell AMPA Receptors in Nervous System Health, Injury and Disease.
Q37722638Impaired geranylgeranyltransferase-I regulation reduces membrane-associated Rho protein levels in aged mouse brain
Q87949028In vivo spatiotemporal dynamics of NG2 glia activity caused by neural electrode implantation
Q52145462Lack of NG2 exacerbates neurological outcome and modulates glial responses after traumatic brain injury.
Q33863489Loss of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice.
Q26767500Low Density Lipoprotein Receptor Related Proteins as Regulators of Neural Stem and Progenitor Cell Function
Q36609965NG2 glia are required for vessel network formation during embryonic development
Q39176941Neuro-psychopharmacological perspective of Orphan receptors of Rhodopsin (class A) family of G protein-coupled receptors
Q55234046Neurofibromatosis type 2 tumor suppressor protein is expressed in oligodendrocytes and regulates cell proliferation and process formation.
Q64059020Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder
Q30425863Oligodendrocyte precursor cells modulate the neuronal network by activity-dependent ectodomain cleavage of glial NG2.
Q34476069Oligodendrocyte precursor cells synthesize neuromodulatory factors
Q33802579Oligodendrocyte precursors migrate along vasculature in the developing nervous system
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Q21710680Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
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Q30667566Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility
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