Increased lymphocyte apoptosis in mouse models of colitis upon ABT-737 treatment is dependent upon BIM expression.

scientific article published on 19 May 2015

Increased lymphocyte apoptosis in mouse models of colitis upon ABT-737 treatment is dependent upon BIM expression. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/CEI.12635
P932PMC publication ID4516450
P698PubMed publication ID25845418

P50authorMartin HausmannQ73799368
P2093author name stringM Fried
G Rogler
C Lutz
M Mozaffari
B L McRae
C L Graff
M Caj
P Cippà
V Tosevski
P2860cites workLamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosisQ74463009
Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathwayQ77061247
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The BH3-mimetic ABT-737 inhibits allogeneic immune responsesQ84201771
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Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasisQ28589263
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Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancerQ33400716
Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cellsQ34039998
Bcl-2-regulated cell death signalling in the prevention of autoimmunityQ34545377
Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft modelsQ34783875
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Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's diseaseQ35364122
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T- and B-cell abnormalities in systemic lupus erythematosusQ36161314
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Bim and the pro-survival Bcl-2 proteins: opposites attract, ERK repelsQ36946423
Bim upregulation by histone deacetylase inhibitors mediates interactions with the Bcl-2 antagonist ABT-737: evidence for distinct roles for Bcl-2, Bcl-xL, and Mcl-1.Q37451892
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Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 2: current managementQ38049776
CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytesQ39744964
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.Q40717909
Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance.Q40943884
Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease.Q41941349
In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy.Q42003082
The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stagesQ42091535
The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugsQ43206184
Imbalanced secondary mucosal antioxidant response in inflammatory bowel diseaseQ44569723
Bystander virus infection prolongs activated T cell survivalQ45750055
The Bcl-2 family antagonist ABT-737 significantly inhibits multiple animal models of autoimmunity.Q45983884
Early preservation of effector functions followed by eventual T cell memory depletion: a model for the delayed onset of the effect of thiopurinesQ46333985
Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.Q49073992
Impaired removal of Vβ8(+) lymphocytes aggravates colitis in mice deficient for B cell lymphoma-2-interacting mediator of cell death (Bim).Q50998106
The origin of anti-nuclear antibodies in bcl-2 transgenic mice.Q52170468
Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14⁺ macrophages.Q54351753
Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivoQ57079498
Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNFα treatmentQ57119828
Increased proportion of CD16+ NK cells in the colonic lamina propria of inflammatory bowel disease patients, but not after azathioprine treatmentQ57971839
Bcl-2 oncogene (B cell lymphoma/leukemia-2) levels correlate with systemic lupus erythematosus disease activityQ73397066
P433issue2
P304page(s)343-356
P577publication date2015-05-19
P1433published inClinical and Experimental ImmunologyQ15716708
P1476titleIncreased lymphocyte apoptosis in mouse models of colitis upon ABT-737 treatment is dependent upon BIM expression.
P478volume181

Reverse relations

cites work (P2860)
Q88624173BCL-2 levels do not predict azathioprine treatment response in inflammatory bowel disease, but inhibition induces lymphocyte apoptosis and ameliorates colitis in mice
Q39277476Dying to protect: cell death and the control of T-cell homeostasis.
Q92493786Imbalance of Controlled Death in Peripheral Blood Lymphocytes in Crohn's Disease and Ulcerative Colitis
Q48104766Isolation and high-dimensional phenotyping of gastrointestinal immune cells.
Q37521403Killing Two Cells with One Stone: Pharmacologic BCL-2 Family Targeting for Cancer Cell Death and Immune Modulation
Q39290025Pharmacological modulation of cell death in organ transplantation.
Q41203716The Extracts of Morinda officinalis and Its Hairy Roots Attenuate Dextran Sodium Sulfate-Induced Chronic Ulcerative Colitis in Mice by Regulating Inflammation and Lymphocyte Apoptosis
Q27324510Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice
Q41092619αMSH prevents ROS-induced apoptosis by inhibiting Foxo1/mTORC2 in mice adipose tissue

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