T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion.

scientific article published on 5 May 2013

T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NI.2606
P698PubMed publication ID23644506
P5875ResearchGate publication ID236638542

P50authorDaniel UtzschneiderQ43123785
P2093author name stringDaniel E Speiser
Silvia A Fuertes Marraco
Dietmar Zehn
Immanuel Luescher
Amandine Legat
Lucie Carrié
P2860cites workViral immune evasion due to persistence of activated T cells without effector functionQ24646943
Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistenceQ27488844
Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsQ28146072
Restoring function in exhausted CD8 T cells during chronic viral infectionQ28289222
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytesQ29616210
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progressionQ29618956
Adaptive immune responses in acute and chronic hepatitis C virus infectionQ29619722
T cell exhaustionQ29620463
Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909.Q33211563
Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigenQ33322422
Efficacy of new antiretroviral drugs in treatment-experienced HIV-infected patients: a systematic review and meta-analysis of recent randomized controlled trialsQ34235156
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunctionQ34570127
Effector and memory CTL differentiationQ34584974
Enhancing SIV-specific immunity in vivo by PD-1 blockadeQ34601856
The immune response during acute HIV-1 infection: clues for vaccine developmentQ34614862
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairmentQ34857689
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.Q34891171
Protective capacity of memory CD8+ T cells is dictated by antigen exposure history and nature of the infectionQ35012041
Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection.Q36228011
Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infectionQ36229254
T cells and viral persistence: lessons from diverse infectionsQ36238129
Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.Q36368095
Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes.Q36400784
Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice.Q36478253
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infectionQ36737159
CD8 T cell dysfunction during chronic viral infection.Q36893050
Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockadeQ36937145
Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adultsQ37046087
High antigen levels are the cause of T cell exhaustion during chronic viral infectionQ37208927
Antigen-independent memory CD8 T cells do not develop during chronic viral infectionQ37591855
Plasticity in programming of effector and memory CD8 T-cell formationQ37763999
Generation of effector CD8+ T cells and their conversion to memory T cellsQ37773428
CD8(+) T cells in preventing HIV infection and diseaseQ37996285
The road not taken: memory T cell fate 'decisions'.Q39382868
Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.Q40695934
Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well platesQ41681194
Role of thymic output in regulating CD8 T-cell homeostasis during acute and chronic viral infection.Q41789710
Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells.Q41862309
Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistenceQ42937121
Phenotypic and functional separation of memory and effector human CD8+ T cellsQ42951823
V beta 5+ T cell receptors skew toward OVA+H-2Kb recognitionQ43516685
Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cellsQ45151385
Viral escape by selection of cytotoxic T cell-resistant virus variants in vivoQ45860175
Molecular signature of CD8+ T cell exhaustion during chronic viral infection.Q51970485
Involvement of both T cell receptor V alpha and V beta variable region domains and alpha chain junctional region in viral antigen recognition.Q52862469
Vaccination-induced functional competence of circulating human tumor-specific CD8 T-cells.Q54571266
IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ PathologyQ61727556
Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokinesQ78952589
Antigen amount dictates CD8+ T-cell exhaustion during chronic viral infection irrespective of the type of antigen presenting cellQ84267427
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)603-610
P577publication date2013-05-05
P1433published inNature ImmunologyQ1071725
P1476titleT cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion.
P478volume14

Reverse relations

cites work (P2860)
Q37368692A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire.
Q98177687A Peptide-Based PD1 Antagonist Enhances T-Cell Priming and Efficacy of a Prophylactic Malaria Vaccine and Promotes Survival in a Lethal Malaria Model
Q92623863A dynamical motif comprising the interactions between antigens and CD8 T cells may underlie the outcomes of viral infections
Q38163290A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
Q52723547Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1.
Q36629345An inducible transgenic mouse breast cancer model for the analysis of tumor antigen specific CD8+ T-cell responses
Q40522642Apoptotic Epitope-Specific CD8+ T Cells and Interferon Signaling Intersect in Chronic Hepatitis C Virus Infection
Q97883527Cancer and HIV-1 Infection: Patterns of Chronic Antigen Exposure
Q39003162Cell-Intrinsic Barriers of T Cell-Based Immunotherapy
Q34374089Cellular immune responses in HIV-negative immunodeficiency with anti-interferon-γ antibodies and opportunistic intracellular microorganisms
Q90479796Checkpoint Inhibitors and Therapeutic Vaccines for the Treatment of Chronic HBV Infection
Q49565575Chromatin dependencies in cancer and inflammation.
Q35798822Consensus nomenclature for CD8(+) T cell phenotypes in cancer
Q30301182Control of pathogenic effector T-cell activities in situ by PD-L1 expression on respiratory inflammatory dendritic cells during respiratory syncytial virus infection
Q38709894De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation
Q90391279Defining 'T cell exhaustion'
Q37252876Demethylation of the PD-1 Promoter Is Imprinted during the Effector Phase of CD8 T Cell Exhaustion.
Q40601767Distinct Metabolic Requirements of Exhausted and Functional Virus-Specific CD8 T Cells in the Same Host.
Q28263550Distinct plasma immune signatures in ME/CFS are present early in the course of illness
Q100455189Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion
Q40414806Dynamic Changes in Chromatin Accessibility Occur in CD8+ T Cells Responding to Viral Infection.
Q36778601Dysregulation of Antiviral Function of CD8(+) T Cells in the Chronic Obstructive Pulmonary Disease Lung. Role of the PD-1-PD-L1 Axis.
Q98665280Early precursor T cells establish and propagate T cell exhaustion in chronic infection
Q36148988Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite Controllers
Q56889801Epigenetic mechanisms of tumor resistance to immunotherapy
Q33835454Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
Q35506504Ex vivo expanded human circulating Vδ1 γδT cells exhibit favorable therapeutic potential for colon cancer
Q52725102Exhaustion of the CD8+ T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta.
Q64882590Expression of Lymphocyte-Activation Gene 3 (LAG-3) Immune Checkpoint Receptor Identifies a Tumor-Reactive T Cell Population in the Peripheral Blood of Patients with Colorectal Cancer.
Q37620568Fallen angels or risen apes? A tale of the intricate complexities of imbalanced immune responses in the pathogenesis and progression of immune-mediated and viral cancers
Q27322730Functional classification of memory CD8(+) T cells by CX3CR1 expression
Q37280990Generating long-lived CD8(+) T-cell memory: Insights from epigenetic programs.
Q38761535Genetic and Epigenetic Regulation of PD-1 Expression
Q37421220Genetic disruption of CD8+ Treg activity enhances the immune response to viral infection
Q91800255Helminth-induced Th2 cell dysfunction is distinct from exhaustion and is maintained in the absence of antigen
Q54266090Hepatitis B Virus-Specific CD8+ T Cells Maintain Functional Exhaustion after Antigen Reexposure in an Acute Activation Immune Environment.
Q37197889High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival
Q90714840IFN-γ and CD25 drive distinct pathologic features during hemophagocytic lymphohistiocytosis
Q64252953Immune Exhaustion: Past Lessons and New Insights from Lymphocytic Choriomeningitis Virus
Q38577713Immune Memory and Exhaustion: Clinically Relevant Lessons from the LCMV Model
Q37381314In vivo blockade of the programmed cell death-1 pathway using soluble recombinant PD-1-Fc enhances CD4+ and CD8+ T cell responses but has limited clinical benefit
Q38309348Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses
Q42244580Increased levels of PD-1 expression on CD8 T cells in patients post-renal transplant irrespective of chronic high EBV viral load.
Q37402534Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than "Exhaustion" of Human CD8 T Cells
Q35783318Inhibitory Receptors Beyond T Cell Exhaustion.
Q28079717Innate and Adaptive Immune Regulation During Chronic Viral Infections
Q59351616Insights From Antiviral Therapy into Immune Responses to HBV and HCV Infection
Q35836864Mechanisms of PD-L1/PD-1-mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eµ-TCL1 CLL mouse model.
Q41266256Memory of Inflammation in Regulatory T Cells
Q99595178Metabolic and epigenetic regulation of T-cell exhaustion
Q47215596Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells
Q57963265Molecular Recalibration of PD-1+ Antigen-Specific T Cells from Blood and Liver
Q26800047Molecular and cellular insights into T cell exhaustion
Q36000835Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion.
Q36569520NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
Q56892392Outcome of Antiviral Immunity in the Liver Is Shaped by the Level of Antigen Expressed in Infected Hepatocytes
Q26829885Overcoming T cell exhaustion in infection and cancer
Q37726682PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors
Q28547901PD-1, PD-L1 and PD-L2 Gene Expression on T-Cells and Natural Killer Cells Declines in Conjunction with a Reduction in PD-1 Protein during the Intensive Phase of Tuberculosis Treatment
Q26796435Pembrolizumab
Q92252194Personal response to immune checkpoint inhibitors of patients with advanced melanoma explained by a computational model of cellular immunity, tumor growth, and drug
Q90576088Precursor exhausted T cells: key to successful immunotherapy?
Q37413039Programmed Death-1 Culls Peripheral Accumulation of High-Affinity Autoreactive CD4 T Cells to Protect against Autoimmunity
Q48312642Programmed cell death-1 expression correlates with disease severity and IL-5 in chronic rhinosinusitis with nasal polyps
Q34197037Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load
Q35070236Protective efficacy of individual CD8+ T cell specificities in chronic viral infection
Q45324828Purging Exhausted Virus-Specific CD8 T Cell Phenotypes by Somatic Cell Reprogramming
Q90220049Re-defining T-Cell Exhaustion: Subset, Function, and Regulation
Q90243326Restoring, releasing or replacing adaptive immunity in chronic hepatitis B
Q100737256Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey
Q57176933Role of Epstein-Barr Virus in the Pathogenesis of Head and Neck Cancers and Its Potential as an Immunotherapeutic Target
Q35871953Selective Loss of Early Differentiated, Highly Functional PD1high CD4 T Cells with HIV Progression
Q92404807Striking a Balance-Cellular and Molecular Drivers of Memory T Cell Development and Responses to Chronic Stimulation
Q50778923T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion?
Q35582265T cell exhaustion during persistent viral infections
Q43874746T cell exhaustion: a means or an end?
Q93001461T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant
Q38815977T cell responses to cytomegalovirus
Q33916550T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection
Q92291598T-cell exhaustion in HIV infection
Q26865338T-cell exhaustion in allograft rejection and tolerance
Q36347369T-cell exhaustion in the tumor microenvironment
Q40217589TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation.
Q92812698TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection
Q35101608Targeting of non-dominant antigens as a vaccine strategy to broaden T-cell responses during chronic viral infection
Q38807692The Human Vaccines Project: A roadmap for cancer vaccine development
Q38259565The Many Unknowns Concerning the Bioenergetics of Exhaustion and Senescence during Chronic Viral Infection
Q47678849The diverse functions of the PD1 inhibitory pathway
Q43600178The speed of change: towards a discontinuity theory of immunity?
Q38161101Tolerance and exhaustion: defining mechanisms of T cell dysfunction
Q40448724Tumor-infiltrating Tim-3+ T cells proliferate avidly except when PD-1 is co-expressed: Evidence for intracellular cross talk.
Q96640583Type 1 Treg cells act as unexpected helpers
Q40794710Type I Interferon Elevates Co-Regulatory Receptor Expression on CMV- and EBV-Specific CD8 T Cells in Chronic Hepatitis C.
Q50535489Understanding Subset Diversity in T Cell Memory.
Q89621125Use of Mass Cytometry to Profile Human T Cell Exhaustion
Q92916578Widespread B cell perturbations in HIV-1 infection afflict naive and marginal zone B cells
Q54415837[Influence of PD-1 on the immunological synapse: a facet of immune regulation ?].
Q90639386iCa2+ Flux, ROS and IL-10 Determines Cytotoxic, and Suppressor T Cell Functions in Chronic Human Viral Infections

Search more.