METTL21B Is a Novel Human Lysine Methyltransferase of Translation Elongation Factor 1A: Discovery by CRISPR/Cas9 Knockout.

scientific article published on 29 June 2017

METTL21B Is a Novel Human Lysine Methyltransferase of Translation Elongation Factor 1A: Discovery by CRISPR/Cas9 Knockout. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/MCP.M116.066308
P932PMC publication ID5724183
P698PubMed publication ID28663172

P2093author name stringMarc R Wilkins
Beeke Wienert
Kate G R Quinlan
Joshua J Hamey
P2860cites workThe CYP27B1 variant associated with an increased risk of autoimmune disease is underexpressed in tolerizing dendritic cells.Q54697963
The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesisQ57667575
The translation elongation factor eEF1A1 couples transcription to translation during heat shock responseQ21128773
Genome engineering using the CRISPR-Cas9 systemQ22122027
Lysine methylation of VCP by a member of a novel human protein methyltransferase familyQ24298017
Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondriaQ24300752
Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2)Q24304158
Human METTL20 is a mitochondrial lysine methyltransferase that targets the β subunit of electron transfer flavoprotein (ETFβ) and modulates its activityQ24306907
Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylationQ24315705
The functional diversity of protein lysine methylationQ26853164
An unexpected journey: lysine methylation across the proteomeQ26864659
Protein methylation at the surface and buried deep: thinking outside the histone boxQ27025874
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal OmegaQ27860809
A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferaseQ27929810
Elongation factor methyltransferase 3--a novel eukaryotic lysine methyltransferase.Q27930495
Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human.Q27931249
Translational roles of elongation factor 2 protein lysine methylationQ27933550
The ribosomal l1 protuberance in yeast is methylated on a lysine residue catalyzed by a seven-beta-strand methyltransferaseQ27933992
Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiaeQ27937223
Methylation of translation-associated proteins in Saccharomyces cerevisiae: Identification of methylated lysines and their methyltransferases.Q27937689
A new type of protein lysine methyltransferase trimethylates Lys-79 of elongation factor 1AQ27939199
Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alphaQ28261644
Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferaseQ28542486
2016 update of the PRIDE database and its related toolsQ28603110
The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A)Q29144900
Genome-scale CRISPR-Cas9 knockout screening in human cellsQ29616044
The HSP70 chaperone machinery: J proteins as drivers of functional specificityQ29616140
Proteomics. Tissue-based map of the human proteomeQ29617248
SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase foldQ29618153
Proteomic Analysis of Arginine Methylation Sites in Human Cells Reveals Dynamic Regulation During Transcriptional ArrestQ30002366
METTL23, a transcriptional partner of GABPA, is essential for human cognitionQ30179391
A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activityQ30179453
METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-κB signaling pathway.Q30973924
The Perseus computational platform for comprehensive analysis of (prote)omics dataQ31110953
The elongation factor 1 A-2 isoform from rabbit: cloning of the cDNA and characterization of the proteinQ32082752
Proteasome-mediated degradation of cotranslationally damaged proteins involves translation elongation factor 1A.Q33552559
Disruption of the methyltransferase-like 23 gene METTL23 causes mild autosomal recessive intellectual disabilityQ33847596
Translation elongation factor 1A mutants with altered actin bundling activity show reduced aminoacyl-tRNA binding and alter initiation via eIF2α phosphorylationQ33947187
eEF1A: thinking outside the ribosomeQ33967234
Large-scale gene function analysis with the PANTHER classification systemQ34358449
A chemical proteomics approach for global analysis of lysine monomethylome profiling.Q35148553
Saccharomyces cerevisiae Eukaryotic Elongation Factor 1A (eEF1A) Is Methylated at Lys-390 by a METTL21-Like MethyltransferaseQ35675772
Improper organization of the actin cytoskeleton affects protein synthesis at initiationQ35676157
The translation elongation factor 1A in tumorigenesis, signal transduction and apoptosis: review article.Q35854271
Extracting Accurate Precursor Information for Tandem Mass Spectra by RawConverterQ36649662
Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based ProteomicsQ36745154
A general molecular affinity strategy for global detection and proteomic analysis of lysine methylationQ36862579
Large-scale global identification of protein lysine methylation in vivoQ37089501
Synchronized mitochondrial and cytosolic translation programsQ37134074
SET for life: biochemical activities and biological functions of SET domain-containing proteinsQ37615671
Emerging role for the cytoskeleton as an organizer and regulator of translationQ37660896
Recent advances in p97/VCP/Cdc48 cellular functionsQ37904023
Emerging roles of lysine methylation on non-histone proteinsQ38557842
Integrating mitochondrial translation into the cellular contextQ38624841
Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded ProteinQ38742965
Protein lysine methylation by seven-β-strand methyltransferasesQ38894639
Immunoaffinity enrichment and mass spectrometry analysis of protein methylationQ39078089
Regulation of Mammalian Mitochondrial Gene Expression: Recent AdvancesQ39174983
Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response.Q39182437
The MaxQuant computational platform for mass spectrometry-based shotgun proteomicsQ39220830
Comprehensive identification of arginine methylation in primary T cells reveals regulatory roles in cell signallingQ39618479
Global identification of protein kinase substrates by protein microarray analysisQ42212790
The activity of a yeast Family 16 methyltransferase, Efm2, is affected by a conserved tryptophan and its N-terminal regionQ42320071
Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulinQ42847905
LysargiNase mirrors trypsin for protein C-terminal and methylation-site identificationQ43023362
Location of seven post-translational modifications in rabbit elongation factor 1 alpha including dimethyllysine, trimethyllysine, and glycerylphosphorylethanolamine.Q44177881
Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome.Q44209738
Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translationQ47840135
Association between SNPs and haplotypes in the METTL21C gene and peak bone mineral density and body composition in Chinese male nuclear families.Q51810405
P433issue12
P921main subjectCas9Q16965677
CRISPRQ412563
CRISPR-Cas methodQ17310682
P304page(s)2229-2242
P577publication date2017-06-29
P1433published inMolecular & Cellular ProteomicsQ6895932
P1476titleMETTL21B Is a Novel Human Lysine Methyltransferase of Translation Elongation Factor 1A: Discovery by CRISPR/Cas9 Knockout.
P478volume16

Reverse relations

cites work (P2860)
Q89175973Chemical and Biochemical Perspectives of Protein Lysine Methylation
Q90364009Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase
Q92515267Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers
Q49981721Regulation of eukaryotic elongation factor 1 alpha (eEF1A) by dynamic lysine methylation
Q58708307The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates

Search more.