SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold

scientific article (publication date: December 2002)

SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0959-440X(02)00391-3
P3181OpenCitations bibliographic resource ID348497
P698PubMed publication ID12504684

P50authorJennifer L. MartinQ17517193
P2093author name stringFiona M McMillan
P2860cites workCrystal structure of YecO from Haemophilus influenzae (HI0319) reveals a methyltransferase fold and a bound S-adenosylhomocysteineQ27636863
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)783-793
P577publication date2002-12-01
P1433published inCurrent Opinion in Structural BiologyQ15758416
P1476titleSAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold
P478volume12

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cites work (P2860)
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Q47408710Functional characterization of O-methyltransferases used to catalyse site-specific methylation in the post-tailoring steps of pradimicin biosynthesis
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Q27648377Functional insights from structures of coactivator-associated arginine methyltransferase 1 domains
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Q40560067Genome-Wide Chromatin Immunoprecipitation Sequencing Analysis of the Penicillium chrysogenum Velvet Protein PcVelA Identifies Methyltransferase PcLlmA as a Novel Downstream Regulator of Fungal Development
Q92753112Genome-Wide Identification and Transcriptional Expression of the METTL21C Gene Family in Chicken
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Q40677885Identification and Characterization of a Ribose 2'-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales
Q36900510Identification and characterization of archaeal and fungal tRNA methyltransferases
Q35088943Identification and characterization of the biosynthetic gene cluster of polyoxypeptin A, a potent apoptosis inducer
Q27487948Identification of Sendai Virus L Protein Amino Acid Residues Affecting Viral mRNA Cap Methylation
Q37859536Identification of a ubiG-like gene involved in ubiquinone biosynthesis from Chlamydophila pneumoniae AR39.
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Q55664127In Vitro Protein Stability of Two Naturally Occurring Thiopurine S-Methyltransferase Variants: Biophysical Characterization of TPMT*6 and TPMT*8.
Q33379284In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites
Q43163229In vitro characterization of the enzyme properties of the phospholipid N-methyltransferase PmtA from Agrobacterium tumefaciens.
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Q38275792Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus
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Q34195129Ligands in PSI structures
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Q29616667Many paths to methyltransfer: a chronicle of convergence
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Q37735417MenA is a promising drug target for developing novel lead molecules to combat Mycobacterium tuberculosis
Q24678196Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms
Q33675873Methyl transfer by substrate signaling from a knotted protein fold
Q36216897Methylation mediated by an anthocyanin, O-methyltransferase, is involved in purple flower coloration in Paeonia
Q47840135Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation
Q27937689Methylation of translation-associated proteins in Saccharomyces cerevisiae: Identification of methylated lysines and their methyltransferases.
Q39036341Methyltransferase-Directed Labeling of Biomolecules and its Applications.
Q27657139Molecular Basis of Substrate Promiscuity for the SAM-Dependent O -Methyltransferase NcsB1, Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin
Q33382585Molecular and functional characterization of a juvenile hormone acid methyltransferase expressed in the corpora allata of mosquitoes
Q34849253Molecular cloning and characterization of juvenile hormone acid methyltransferase in the honey bee, Apis mellifera, and its differential expression during caste differentiation
Q48080573Molecular cloning and characterization of tetrahydroprotoberberine cis-N-methyltransferase, an enzyme involved in alkaloid biosynthesis in opium poppy
Q39966072Molecular defects caused by temperature-sensitive mutations in Semliki Forest virus nsP1.
Q27938769Multiple Motif Scanning to identify methyltransferases from the yeast proteome
Q45369883Mutational effects of the consensus aromatic residues in the mRNA capping domain of Bamboo mosaic virus on GTP methylation and virus accumulation
Q24816614Natural history of S-adenosylmethionine-binding proteins
Q92557746Network dynamics of the yeast methyltransferome
Q33938178Phosphoethanolamine methyltransferases in phosphocholine biosynthesis: functions and potential for antiparasite therapy.
Q31111333Phosphoproteomic analysis of Methanohalophilus portucalensis FDF1(T) identified the role of protein phosphorylation in methanogenesis and osmoregulation
Q61806013Potential for Heightened Sulfur-Metabolic Capacity in Coastal Subtropical Microalgae
Q88740551Preparation, Assay, and Application of Chlorinase SalL for the Chemoenzymatic Synthesis of S-Adenosyl-l-Methionine and Analogs
Q43232429Preparation, crystallization and preliminary X-ray diffraction analysis of PH1948, predicted RNA methyltransferase from Pyrococcus horikoshii
Q37726342Protein arginine methyltransferases: nuclear receptor coregulators and beyond
Q33959579Proteomics in the liver of gilthead sea bream (Sparus aurata) to elucidate the cellular response induced by the intake of maslinic acid.
Q28493137Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase
Q37685286Purification, crystallization and X-ray crystallographic studies on a putative methyltransferase, YtqB, from Bacillus subtilis
Q35539371Purification, crystallization and diffraction studies of the methyltransferases BT_2972 and BVU_3255 from antibiotic-resistant pathogens of the genus Bacteroides from the human intestine
Q47220653Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics
Q30320181Putrescine N-methyltransferase in Solanum tuberosum L., a calystegine-forming plant
Q96128014Pyridoxal-5'-phosphate-dependent alkyl transfer in nucleoside antibiotic biosynthesis
Q38699925QUASIMODO 3 (QUA3) is a putative homogalacturonan methyltransferase regulating cell wall biosynthesis in Arabidopsis suspension-cultured cells.
Q27641109Recognition of ribosomal protein L11 by the protein trimethyltransferase PrmA
Q38095914Ribonucleoproteins in archaeal pre-rRNA processing and modification.
Q38062519S-adenosyl-methionine-dependent methyltransferases: highly versatile enzymes in biocatalysis, biosynthesis and other biotechnological applications.
Q42793465S-adenosylmethionine-binding properties of a bacterial phospholipid N-methyltransferase.
Q38625953SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases
Q49862141Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.
Q52707778Selective terminal methylation of a tRNA wobble base.
Q39683334Sequence-function analysis of the Sendai virus L protein domain VI.
Q46908139Specificity of the CheR2 methyltransferase in Pseudomonas aeruginosa is directed by a C-terminal pentapeptide in the McpB chemoreceptor
Q33658853Spermine synthase
Q37487365Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Q60960278Structural Basis of DNMT1 and DNMT3A-Mediated DNA Methylation
Q47391281Structural Basis of Mitochondrial Transcription Initiation
Q95601805Structural Basis of RNA Cap Modification by SARS-CoV-2 Coronavirus
Q27671608Structural Basis of Substrate Recognition in Human Nicotinamide N -Methyltransferase
Q27650629Structural Basis of Substrate Recognition in Thiopurine S -Methyltransferase † ‡
Q27684887Structural Insights into the Catalytic Mechanism of Synechocystis Magnesium Protoporphyrin IX O -Methyltransferase (ChlM)
Q27684530Structural analysis of coniferyl alcohol 9-O-methyltransferase from Linum nodiflorum reveals a novel active-site environment
Q27667462Structural and Functional Characterization of Rv2966c Protein Reveals an RsmD-like Methyltransferase from Mycobacterium tuberculosis and the Role of Its N-terminal Domain in Target Recognition
Q27657763Structural and biochemical insights into 2'-O-methylation at the 3'-terminal nucleotide of RNA by Hen1
Q37419993Structural and functional characterization of CalS11, a TDP-rhamnose 3'-O-methyltransferase involved in calicheamicin biosynthesis
Q27679181Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis
Q27679679Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ
Q29568202Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes
Q34687096Structural and functional studies of S-adenosyl-L-methionine binding proteins: a ligand-centric approach
Q35910211Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex
Q27678821Structural basis for S-adenosylmethionine binding and methyltransferase activity by mitochondrial transcription factor B1
Q27657231Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2
Q97692635Structural basis of RNA cap modification by SARS-CoV-2
Q52338894Structural insights into the RNA methyltransferase domain of METTL16.
Q27482178Structural insights into the mechanism and evolution of the vaccinia virus mRNA cap N7 methyl-transferase
Q27683006Structure analysis of geranyl pyrophosphate methyltransferase and the proposed reaction mechanism of SAM-dependent C-methylation
Q41952467Structure and Biophysical Characterization of the S-Adenosylmethionine-dependent O-Methyltransferase PaMTH1, a Putative Enzyme Accumulating during Senescence of Podospora anserina
Q27478377Structure and Function of Flavivirus NS5 Methyltransferase
Q37781847Structure and function of eukaryotic fatty acid synthases
Q27690685Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase
Q35590837Structure and mechanism of an antibiotics-synthesizing 3-hydroxykynurenine C-methyltransferase
Q24646712Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM
Q27689753Structure and possible mechanism of the CcbJ methyltransferase from Streptomyces caelestis
Q27678240Structure of Geranyl Diphosphate C -Methyltransferase from Streptomyces coelicolor and Implications for the Mechanism of Isoprenoid Modification
Q41975063Structure of a class II TrmH tRNA-modifying enzyme from Aquifex aeolicus.
Q27681235Structure of an As(III) S -Adenosylmethionine Methyltransferase: Insights into the Mechanism of Arsenic Biotransformation
Q27642733Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity
Q42255927Structure of the SHR-SCR heterodimer bound to the BIRD/IDD transcriptional factor JKD.
Q27677448Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA
Q24299789Structure of the essential MTERF4:NSUN4 protein complex reveals how an MTERF protein collaborates to facilitate rRNA modification
Q46865967Structure, function, and evolution of plant O-methyltransferases
Q27666367Structure-Function Analyses of a Caffeic Acid O -Methyltransferase from Perennial Ryegrass Reveal the Molecular Basis for Substrate Preference
Q27656089Structure-Function Relationships in Miscoding by Sulfolobus solfataricus DNA Polymerase Dpo4: GUANINE N2,N2-DIMETHYL SUBSTITUTION PRODUCES INACTIVE AND MISCODING POLYMERASE COMPLEXES
Q37635194Structure-based drug design of catechol-O-methyltransferase inhibitors for CNS disorders
Q40525882Structure-function analysis of severe acute respiratory syndrome coronavirus RNA cap guanine-N7-methyltransferase.
Q41776527Structure-function relationships of wheat flavone O-methyltransferase: Homology modeling and site-directed mutagenesis
Q37812407Structures of ribonucleoprotein particle modification enzymes.
Q47434368Substrate Scope of O-Methyltransferase from Streptomyces peucetius for Biosynthesis of Diverse Natural Products Methoxides
Q46910405The Arabidopsis Exine Formation Defect (EFD) gene is required for primexine patterning and is critical for pollen fertility
Q92988604The Common Partner of Several Methyltransferases TRMT112 Regulates the Expression of N6AMT1 Isoforms in Mammalian Cells
Q27657980The Crystal Structure of the Novobiocin Biosynthetic Enzyme NovP: The First Representative Structure for the TylF O-Methyltransferase Superfamily
Q92800161The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity
Q64928223The Evolution of Substrate Specificity by tRNA Modification Enzymes.
Q92290537The Genetic Basis of Toxin Biosynthesis in Dinoflagellates
Q33312940The OSU1/QUA2/TSD2-encoded putative methyltransferase is a critical modulator of carbon and nitrogen nutrient balance response in Arabidopsis
Q42320071The activity of a yeast Family 16 methyltransferase, Efm2, is affected by a conserved tryptophan and its N-terminal region
Q27934553The carboxyl-terminal extension of yeast tRNA m5C methyltransferase enhances the catalytic efficiency of the amino-terminal domain
Q27649572The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site
Q27651988The crystal structure of a mammalian fatty acid synthase
Q36476600The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii
Q27646904The crystal structure ofM. lepraeML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria
Q30407348The diversity of polyketide synthase genes from sugarcane-derived fungi.
Q37846576The endosymbiont Amoebophilus asiaticus encodes an S-adenosylmethionine carrier that compensates for its missing methylation cycle
Q26853164The functional diversity of protein lysine methylation
Q35005892The human WBSCR22 protein is involved in the biogenesis of the 40S ribosomal subunits in mammalian cells
Q64082977The interactome of a family of potential methyltransferases in HeLa cells
Q91735801The multistructural forms of box C/D ribonucleoprotein particles
Q28476204The pathogenic properties of a novel and conserved gene product, KerV, in proteobacteria
Q43044010The purification, crystallization and preliminary structural characterization of PhzM, a phenazine-modifying methyltransferase from Pseudomonas aeruginosa.
Q26824482The structural biology of enzymes involved in natural product glycosylation
Q35781843The structure and function of small nucleolar ribonucleoproteins
Q38031740The structures of type I polyketide synthases
Q36489362The type I fatty acid and polyketide synthases: a tale of two megasynthases
Q28535458Theoretical insights into catalytic mechanism of protein arginine methyltransferase 1
Q33611509Transcriptional responses in honey bee larvae infected with chalkbrood fungus
Q38759584Trifluoroselenomethionine: A New Unnatural Amino Acid
Q34454874Uncovering the human methyltransferasome
Q37718564Vitamin K2 in electron transport system: are enzymes involved in vitamin K2 biosynthesis promising drug targets?

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