Intratumor OX40 stimulation inhibits IRF1 expression and IL-10 production by Treg cells while enhancing CD40L expression by effector memory T cells

scientific article published in December 2011

Intratumor OX40 stimulation inhibits IRF1 expression and IL-10 production by Treg cells while enhancing CD40L expression by effector memory T cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/EJI.201141700
P698PubMed publication ID22229156
P5875ResearchGate publication ID221732983

P50authorMario Paolo ColomboQ41570231
Alessia BurocchiQ42574397
P2093author name stringSilvia Piconese
Andrea Gorzanelli
Paola Pittoni
P2860cites workInterleukin-10: new perspectives on an old cytokineQ24653771
OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cellsQ28188488
Cancer despite immunosurveillance: immunoselection and immunosubversionQ28263865
The TRAIL to selective tumor deathQ28504568
IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene inductionQ28509760
Regulatory T cell lineage specification by the forkhead transcription factor foxp3Q28510328
OX40/OX40L costimulation affects induction of Foxp3+ regulatory T cells in part by expanding memory T cells in vivoQ28585756
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survivalQ29547865
How regulatory T cells workQ29614262
The regulation of IL-10 production by immune cellsQ29615479
Genomic definition of multiple ex vivo regulatory T cell subphenotypesQ33778238
Control of immunity by the TNFR-related molecule OX40 (CD134)Q33899607
Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of Foxp3 expression and Treg function.Q34158278
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunityQ34161493
IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cellsQ34318928
CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacyQ58235013
Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of ColitisQ61779891
A non-redundant role for OX40 in the competitive fitness of Treg in response to IL-2Q62040086
OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligandQ71420856
Engagement of the OX-40 receptor in vivo enhances antitumor immunityQ73407121
Regulation of transcriptional activity of the murine CD40 ligand promoter in response to signals through TCR and the costimulatory molecules CD28 and CD2Q73630460
Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40Q77966184
Differential CD40/CD40L expression results in counteracting antitumor immune responsesQ79717949
The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cellsQ80146459
Suppression of mature dendritic cell function by regulatory T cells in vivo is abrogated by CD40 licensingQ80523542
Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cellsQ80641619
A unique subset of CD4+CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironmentQ80726091
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10Q80785928
Distinct and overlapping roles of interleukin-10 and CD25+ regulatory T cells in the inhibition of antitumor CD8 T-cell responsesQ81223194
Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cellsQ34582700
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfacesQ34590015
Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responsesQ34626052
A therapeutic OX40 agonist dynamically alters dendritic, endothelial, and T cell subsets within the established tumor microenvironment.Q34682173
OX40 ligand shuts down IL-10-producing regulatory T cellsQ35016533
IFN-inducible GTPases and immunity to intracellular pathogensQ35920524
OX40 costimulation turns off Foxp3+ Tregs.Q36007580
Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is rightQ36224132
Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glandsQ36229323
Dendritic cells infiltrating tumors cotransduced with granulocyte/macrophage colony-stimulating factor (GM-CSF) and CD40 ligand genes take up and present endogenous tumor-associated antigens, and prime naive mice for a cytotoxic T lymphocyte responsQ36375059
Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibodyQ36376567
OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejectionQ36537926
Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survivalQ36696891
CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell primingQ36946552
Nonredundant roles for B cell-derived IL-10 in immune counter-regulationQ37409360
Molecular mechanism and function of CD40/CD40L engagement in the immune system.Q37474929
Plasticity of CD4(+) FoxP3(+) T cellsQ37509592
Foxp3+ regulatory T cells: differentiation, specification, subphenotypesQ37523266
Heterogeneity of CD4+ memory T cells: functional modules for tailored immunityQ37578374
OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology.Q37761492
Developmental plasticity of Foxp3+ regulatory T cellsQ37786736
Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection.Q38327926
Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanomaQ39830418
OX40 is required for regulatory T cell-mediated control of colitisQ40066564
T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposisQ40909943
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammationQ41762357
Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive miceQ42587994
TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand.Q42972510
OX40 ligand-transduced tumor cell vaccine synergizes with GM-CSF and requires CD40-Apc signaling to boost the host T cell antitumor responseQ45857323
Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR.Q45879987
Anthrax lethal toxin enhances TNF-induced endothelial VCAM-1 expression via an IFN regulatory factor-1-dependent mechanismQ46587215
Hybrid Treg cells: steel frames and plastic exteriorsQ47781759
IFN-alpha induces the human IL-10 gene by recruiting both IFN regulatory factor 1 and Stat3.Q47817002
Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growthQ50539541
OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor.Q51963656
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)3615-3626
P577publication date2011-12-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleIntratumor OX40 stimulation inhibits IRF1 expression and IL-10 production by Treg cells while enhancing CD40L expression by effector memory T cells
P478volume41

Reverse relations

cites work (P2860)
Q56889692A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity
Q42099442A diametric role for OX40 in the response of effector/memory CD4+ T cells and regulatory T cells to alloantigen
Q35427446Agonist antibodies to TNFR molecules that costimulate T and NK cells
Q39303777CD8+ T cell-independent tumor regression induced by Fc-OX40L and therapeutic vaccination in a mouse model of glioma.
Q42571627Convergences and divergences of thymus- and peripherally derived regulatory T cells in cancer
Q35922726Effector function of CTLs is increased by irradiated colorectal tumor cells that modulate OX-40L and 4-1BBL and is reversed following dual blockade
Q38749824Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy
Q48131172Eradication of spontaneous malignancy by local immunotherapy.
Q42222888Human OX40 tunes the function of regulatory T cells in tumor and nontumor areas of hepatitis C virus-infected liver tissue.
Q39235364Local expression of interleukin-2 by B16 melanoma cells results in decreased tumour growth and long-term tumour dormancy
Q38943411Nanoparticle formulation enhanced protective immunity provoked by PYGPI8p-transamidase related protein (PyTAM) DNA vaccine in Plasmodium yoelii malaria model
Q94552595New pathways in immune stimulation: targeting OX40
Q38374889OX40 Agonists and Combination Immunotherapy: Putting the Pedal to the Metal.
Q33627023Radiation-induced modulation of costimulatory and coinhibitory T-cell signaling molecules on human prostate carcinoma cells promotes productive antitumor immune interactions
Q38948909Review on the immunotherapy strategies against metastatic colorectal carcinoma.
Q92534116T-Regulatory Cells In Tumor Progression And Therapy
Q53652973TLR2-dependent amelioration of allergic airway inflammation by parasitic nematode type II MIF in mice.
Q90094371Therapeutic strategies for the costimulatory molecule OX40 in T-cell-mediated immunity
Q27008946Treg functional stability and its responsiveness to the microenvironment
Q89506076Tumor necrosis factor receptor family costimulation increases regulatory T-cell activation and function via NF-κB
Q52643529Updates on immunotherapy for colorectal cancer.

Search more.