RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis.

scientific article published in February 2004

RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1359/JBMR.0301233
P698PubMed publication ID14969390

P2093author name stringLin Ma
Regis J O'Keefe
Ping Li
Edward M Schwarz
Lianping Xing
Brendan F Boyce
P2860cites workMechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritisQ34967810
TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritisQ35788463
Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritisQ35789185
P433issue2
P921main subjectinflammationQ101991
P304page(s)207-213
P577publication date2004-02-01
P1433published inJournal of Bone and Mineral ResearchQ15750941
P1476titleRANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis.
P478volume19

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cites work (P2860)
Q36587768Activated NF-κB in bone marrow mesenchymal stem cells from systemic lupus erythematosus patients inhibits osteogenic differentiation through downregulating Smad signaling.
Q36733053Advances in osteoclast biology reveal potential new drug targets and new roles for osteoclasts
Q38818913Age-dependent alterations in osteoblast and osteoclast activity in human cancellous bone
Q54684809Alteration of newly induced endochondral bone formation in adult mice without tumour necrosis factor receptor 1.
Q26774874Animal Models of Bone Loss in Inflammatory Arthritis: from Cytokines in the Bench to Novel Treatments for Bone Loss in the Bedside-a Comprehensive Review
Q43252993Antitumor necrotic factor agent promotes BMP-2-induced ectopic bone formation
Q36702302Bone Mineral Density, Bone Turnover, and Systemic Inflammation in Non-cirrhotics with Chronic Hepatitis C
Q36532536Bone cell precursors and the pathophysiology of bone loss
Q34001621Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention
Q33896725Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment
Q58774487Bone erosions in rheumatoid arthritis: recent developments in pathogenesis and therapeutic implications
Q38598776Can rheumatoid arthritis ever cease to exist: a review of various therapeutic modalities to maintain drug-free remission?
Q35769060Cells of the synovium in rheumatoid arthritis. Osteoclasts
Q35901092Clinical development of anti-RANKL therapy
Q34252489Cytokine-mediated bone destruction in rheumatoid arthritis
Q26782454Cytokines and MicroRNAs as Candidate Biomarkers for Systemic Lupus Erythematosus
Q28303865Cytokines in the pathogenesis of rheumatoid arthritis
Q37342578Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT.
Q28295303Disorders of Bone Remodeling
Q53742233Editorial: Inflammatory Osteoclasts: A Different Breed of Bone Eaters?
Q37880163Effects of inflammatory and anti-inflammatory cytokines on the bone
Q35901078Erosive arthritis
Q26863571Feedback inhibition of osteoclastogenesis during inflammation by IL-10, M-CSF receptor shedding, and induction of IRF8
Q38295616Focal bone involvement in inflammatory arthritis: the role of IL17.
Q35075554Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation
Q43190058How does joint remodeling work?: new insights in the molecular regulation of the architecture of joints
Q36394731Human scaphoid non-unions exhibit increased osteoclast activity compared to adjacent cancellous bone
Q40909592IL-1 mediates TNF-induced osteoclastogenesis
Q34545945IL-11 produced by breast cancer cells augments osteoclastogenesis by sustaining the pool of osteoclast progenitor cells
Q64118198Imaging the Bone-Immune Cell Interaction in Bone Destruction
Q38114066Immunological reaction in TNF-α-mediated osteoclast formation and bone resorption in vitro and in vivo
Q35913720Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
Q38618883Inflammatory Cell Migration in Rheumatoid Arthritis: A Comprehensive Review
Q91925637Inflammatory processes and elevated osteoclast activity chaperon atrophic non-union establishment in a murine model
Q37829690Interaction between the skeletal and immune systems in cancer: mechanisms and clinical implications
Q35011305Interleukin-3 plays dual roles in osteoclastogenesis by promoting the development of osteoclast progenitors but inhibiting the osteoclastogenic process
Q35775909Kruppel-like factor 2 (KLF2) regulates monocyte differentiation and functions in mBSA and IL-1β-induced arthritis
Q53221110Lineage-committed osteoclast precursors circulate in blood and settle down into bone.
Q37143025Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography.
Q36618009Mechanisms of bone loss in rheumatoid arthritis
Q34246045Mice Deficient in NF-κB p50 and p52 or RANK Have Defective Growth Plate Formation and Post-natal Dwarfism.
Q38721980Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy.
Q35939914Molecular basis of requirement of receptor activator of nuclear factor κB signaling for interleukin 1-mediated osteoclastogenesis.
Q34488033Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice
Q37363042NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism
Q64235920New Insights for RANKL as a Proinflammatory Modulator in Modeled Inflammatory Arthritis
Q36246080OsteoRheumatology: a new discipline?
Q28593804Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha
Q36568536Osteoclast fusion and regulation by RANKL-dependent and independent factors
Q79370827Osteoclastic differentiation and function regulated by old and new pathways
Q35755039Osteoclasts: New Insights
Q38109578Osteoimmunology and bone homeostasis: relevance to spondyloarthritis
Q37626412Osteoimmunology and the effects of the immune system on bone
Q47944184Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems.
Q37544448Osteoimmunology: crosstalk between the immune and bone systems
Q24655113Osteoimmunology: interactions of the bone and immune system
Q28294477Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
Q64071144Overview of RAW264.7 for osteoclastogensis study: Phenotype and stimuli
Q45091256PC-PLC is involved in osteoclastogenesis induced by TNF-α through upregulating IP3R1 expression
Q36090203Pathological role of osteoclast costimulation in arthritis-induced bone loss.
Q37115802Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis
Q51426261RANK ligand and TNF-alpha mediate acid-induced bone calcium efflux in vitro.
Q37738754RANK ligand: effects of inhibition.
Q46515547RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis
Q34333628Receptor Activator of NF-κB (RANK) Cytoplasmic IVVY535–538 Motif Plays an Essential Role in Tumor Necrosis Factor-α (TNF)-mediated Osteoclastogenesis
Q36860987Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease.
Q33946711Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentiation
Q38102876Regulation of TNF-α with a focus on rheumatoid arthritis
Q37118782Review: Immune cells and mediators of inflammatory arthritis
Q38215027Role of periodontal ligament fibroblasts in osteoclastogenesis: a review
Q36177501Roles for NF-kappaB and c-Fos in osteoclasts
Q37670112Runx1-mediated regulation of osteoclast differentiation and function
Q40463168Soluble RANKL Cleaved from Activated Lymphocytes by TNF-α-Converting Enzyme Contributes to Osteoclastogenesis in Periodontitis.
Q34950018Supplementation with fish oil and genistein, individually or in combination, protects bone against the adverse effects of methotrexate chemotherapy in rats
Q50523565Synovial Immunophenotype and Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis Patients: Relationship to Treatment Response and Radiologic Prognosis.
Q37801555Systemic bone effects of biologic therapies in rheumatoid arthritis and ankylosing spondylitis
Q93053015TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
Q35760837TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J.
Q48088552TNF-α promotes osteoclastogenesis through JNK signaling-dependent induction of Semaphorin3D expression in estrogen-deficiency induced osteoporosis.
Q52784518Targeting Notch-Activated M1 Macrophages Attenuates Joint Tissue Damage in a Mouse Model of Inflammatory Arthritis.
Q36093022The IVVY Motif and Tumor Necrosis Factor Receptor-associated Factor (TRAF) Sites in the Cytoplasmic Domain of the Receptor Activator of Nuclear Factor κB (RANK) Cooperate to Induce Osteoclastogenesis
Q43494262The evolving systemic and local biomarker milieu at different stages of disease progression in rat adjuvant-induced arthritis
Q41973199The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritis
Q39248512The role of stromal cells in inflammatory bone loss
Q48867598The sphingosine-1-phosphate receptor 1 binding molecule FTY720 inhibits osteoclast formation in rats with ligature-induced periodontitis
Q33360030The synovio-entheseal complex in enthesoarthritis
Q54460498Tumor necrosis factor-inhibiting therapy preferentially targets bone destruction but not synovial inflammation in a tumor necrosis factor-driven model of rheumatoid arthritis.
Q36901702Use of a whole-slide imaging system to assess the presence and alteration of lymphatic vessels in joint sections of arthritic mice
Q39982542Value of digital X-ray radiogrammetry in the assessment of inflammatory bone loss in rheumatoid arthritis
Q93052617Vitamin D Inhibition of TRPV5 Expression During Osteoclast Differentiation
Q80463776[Bone metabolism: molecular mechanisms]
Q44536102p-Coumaric acid, a dietary polyphenol ameliorates inflammation and curtails cartilage and bone erosion in the rheumatoid arthritis rat model.