N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death.

scientific article published in September 2000

N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/1097-4644(20010101)80:1<53::AID-JCB60>3.0.CO;2-E
P698PubMed publication ID11029754

P2093author name stringG Gao
Q P Dou
P433issue1
P921main subjectapoptotic processQ14599311
P304page(s)53-72
P577publication date2000-09-01
P1433published inJournal of Cellular BiochemistryQ6294917
P1476titleN-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome C release and apoptotic cell death.
P478volume80

Reverse relations

cites work (P2860)
Q57491941A Calpain-Like Protein Is Involved in the Execution Phase of Programmed Cell Death of
Q42868297A novel calpain inhibitor for treatment of transient retinal ischemia in the rat.
Q35613434A46, a benzothiophene-derived compound, suppresses Jak2-mediated pathologic cell growth
Q38791117Abrus agglutinin is a potent anti-proliferative and anti-angiogenic agent in human breast cancer.
Q40709009Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin.
Q33470703Activation of calpain-1 in human carotid artery atherosclerotic lesions
Q42132317Administration of low dose estrogen attenuates gliosis and protects neurons in acute spinal cord injury in rats
Q42828076Akt is activated in response to an apoptotic signal.
Q44614770Anti-apoptotic effect of HIV protease inhibitors via direct inhibition of calpain.
Q30923800Antiproliferative and apoptotic effect of TGF-β1 in bovine mammary epithelial BME-UV1 cells
Q44301813Apoptosis induction by the dual-action DNA- and protein-reactive antitumor drug irofulven is largely Bcl-2-independent
Q36840797Arsenic trioxide and neuroblastoma cytotoxicity.
Q40150435Arsenic trioxide-induced neuroblastoma cell death is accompanied by proteolytic activation of nuclear Bax.
Q37111253Aspirin Has Antitumor Effects via Expression of Calpain Gene in Cervical Cancer Cells
Q36501184BCL-2 in the crosshairs: tipping the balance of life and death
Q40578148BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
Q31927085Bax kappa, a novel Bax splice variant from ischemic rat brain lacking an ART domain, promotes neuronal cell death
Q42149700Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells
Q37404738Biological properties of garlic and garlic-derived organosulfur compounds
Q40187206Blebbishield emergency program: an apoptotic route to cellular transformation
Q40288049CD44 ligation induces caspase-independent cell death via a novel calpain/AIF pathway in human erythroleukemia cells
Q41418176Calcium influx-mediated translocation of m-calpain induces Ku80 cleavage and enhances the Ku80-related DNA repair pathway.
Q44013231Calpain and mitochondria in ischemia/reperfusion injury
Q34175815Calpain inhibition attenuates intracellular changes in muscle cells in response to extracellular inflammatory stimulation
Q30320598Calpain inhibitor (BSF 409425) diminishes ischemia/reperfusion-induced damage of rabbit heart mitochondria
Q39723688Calpain plays a central role in 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in cerebellar granule neurons.
Q39225690Calpain, Atg5 and Bak play important roles in the crosstalk between apoptosis and autophagy induced by influx of extracellular calcium
Q40682509Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax.
Q39674453Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis
Q39947179Calpain-mediated androgen receptor breakdown in apoptotic prostate cancer cells
Q53597468Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.
Q38009779Calpains, mitochondria, and apoptosis
Q90746017Calpastatin peptide attenuates early brain injury following experimental subarachnoid hemorrhage
Q92487118Cardioprotective effects of Prolame and SNAP are related with nitric oxide production and with diminution of caspases and calpain-1 activities in reperfused rat hearts
Q33784712Caspase-3 is transiently activated without cell death during early antigen driven expansion of CD8(+) T cells in vivo
Q27331342Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns.
Q31116411Caspase-mediated death of newly formed neurons in the adult rat dentate gyrus following status epilepticus
Q34284072Caspases: a molecular switch node in the crosstalk between autophagy and apoptosis
Q24654460Cellular interplay between neurons and glia: toward a comprehensive mechanism for excitotoxic neuronal loss in neurodegeneration
Q38869779Characterization of Apoptosis Signaling Cascades During the Differentiation Process of Human Neural ReNcell VM Progenitor Cells In Vitro
Q41359733Characterization of methyl-beta-cyclodextrin toxicity in NGF-differentiated PC12 cell death.
Q40647520Cisplatin triggers apoptotic or nonapoptotic cell death in Fanconi anemia lymphoblasts in a concentration-dependent manner.
Q46121006Compartmental analysis of steady-state diaphragm Ca2+ kinetics in chronic congestive heart failure
Q37424410Conformational changes and protein stability of the pro-apoptotic protein Bax.
Q36321947Conformational control of Bax localization and apoptotic activity by Pro168.
Q53531534Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury.
Q33869940Cross-talk between IGF-1 and estrogen receptors attenuates intracellular changes in ventral spinal cord 4.1 motoneuron cells because of interferon-gamma exposure
Q40671716Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis
Q79387221Cross-talk between calpain and caspase-3/-7 in cisplatin-induced apoptosis of melanoma cells: a major role of calpain inhibition in cell death protection and p53 status
Q36916903Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo
Q56880500Death effector activation in the subventricular zone subsequent to perinatal hypoxia/ischemia
Q34411011Degradation of the transcription factors NF-κB, STAT3, and STAT5 is involved in Entamoeba histolytica-induced cell death in Caco-2 colonic epithelial cells
Q39580397Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines
Q35662047Differential effects of ethanol on c-jun N-terminal kinase, 14-3-3 proteins, and Bax in postnatal day 4 and postnatal day 7 rat cerebellum
Q43902939Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cells
Q36325128Distinct cell death pathways triggered by the adenovirus early region 4 ORF 4 protein
Q37154960Disulfiram promotes the conversion of carcinogenic cadmium to a proteasome inhibitor with pro-apoptotic activity in human cancer cells.
Q40400306Early mitochondrial alterations in ATRA-induced cell death
Q38957058Effects of copper overload in P19 neurons: impairment of glutathione redox homeostasis and crosstalk between caspase and calpain protease systems in ROS-induced apoptosis
Q36266206Employing new cellular therapeutic targets for Alzheimer's disease: a change for the better?
Q57223169Erythrocytes: death of a mummy
Q42286702Ethanol influences on Bax translocation, mitochondrial membrane potential, and reactive oxygen species generation are modulated by vitamin E and brain-derived neurotrophic factor
Q35083349Gold(III)-dithiocarbamato peptidomimetics in the forefront of the targeted anticancer therapy: preclinical studies against human breast neoplasia.
Q39977177HCCS1 overexpression induces apoptosis via cathepsin D and intracellular calcium, and HCCS1 disruption in mice causes placental abnormality
Q38989333HIV-1 protease-induced apoptosis
Q38639870HM015k, a Novel Silybin Derivative, Multi-Targets Metastatic Ovarian Cancer Cells and Is Safe in Zebrafish Toxicity Studies
Q44956681Heat-induced apoptosis of mouse meiotic cells is suppressed by ectopic expression of testis-specific calpastatin
Q44789133High levels of cellular prion protein improve astrocyte development
Q42565249ICP10PK inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin MPP+.
Q36662334IFNB1/interferon-β-induced autophagy in MCF-7 breast cancer cells counteracts its proapoptotic function
Q36554860Implication of calpain in neuronal apoptosis. A possible regulation of Alzheimer's disease
Q36090325Increased sensitivity of African American triple negative breast cancer cells to nitric oxide-induced mitochondria-mediated apoptosis
Q40722126Induction of apoptosis by the new anticancer drug XK469 in human ovarian cancer cell lines
Q37158093Inhibition of tumor proteasome activity by gold-dithiocarbamato complexes via both redox-dependent and -independent processes
Q22001543Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum
Q36856535Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity.
Q40817417Involvement of Bcl-2 and Bax in photodynamic therapy-mediated apoptosis. Antisense Bcl-2 oligonucleotide sensitizes RIF 1 cells to photodynamic therapy apoptosis
Q35182059Low dose estrogen prevents neuronal degeneration and microglial reactivity in an acute model of spinal cord injury: effect of dosing, route of administration, and therapy delay
Q38170009Lysosomal membrane permeabilization as a key player in brain ischemic cell death: a "lysosomocentric" hypothesis for ischemic brain damage
Q43002647Mechanism of action of interleukin-2 (IL-2)-Bax, an apoptosis-inducing chimaeric protein targeted against cells expressing the IL-2 receptor
Q38326656Mechanisms of myocardial ischemia-reperfusion injury and the cytoprotective role of minocycline: scope and limitations
Q41767236Mitochondrial oligomers boost glycolysis in cancer stem cells to facilitate blebbishield-mediated transformation after apoptosis
Q42910802Molecular details of Bax activation, oligomerization, and membrane insertion.
Q39009577Natural compound Alternol induces oxidative stress-dependent apoptotic cell death preferentially in prostate cancer cells
Q38222884Neuroprotective Mechanisms of Taurine against Ischemic Stroke
Q35081723Neuroprotective strategies against calpain-mediated neurodegeneration
Q37189804Novel 8-hydroxylquinoline analogs induce copper-dependent proteasome inhibition and cell death in human breast cancer cells.
Q40444757Overexpression of Bax sensitizes prostate cancer cells to TGF-beta induced apoptosis.
Q40643972Oxidized low-density lipoprotein induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells
Q35359342P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism.
Q38747840Phosphorylation Impacts N-end Rule Degradation of the Proteolytically Activated Form of BMX Kinase
Q28534817Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells
Q92080181Protective effect of hsa-miR-570-3p targeting CD274 on triple negative breast cancer by blocking PI3K/AKT/mTOR signaling pathway
Q60603698Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens
Q37148849Pyrrolidine dithiocarbamate-zinc(II) and -copper(II) complexes induce apoptosis in tumor cells by inhibiting the proteasomal activity
Q40511549Rapid induction of the intrinsic apoptotic pathway by L-glutamine starvation
Q52721187Regulatory role of calpain in neuronal death.
Q33752784Release of Cytochrome C from Bax Pores at the Mitochondrial Membrane
Q39685758Requirement of BAX for efficient adenovirus-induced apoptosis
Q44100053Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells
Q44023078Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury
Q42264580Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis.
Q40632735Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions.
Q37521398Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium
Q81860462Stress in the brain: novel cellular mechanisms of injury linked to Alzheimer's disease
Q31046923Study of apoptosis in human liver cancers.
Q35921561Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress
Q39792514The HSV-2 mutant DeltaPK induces melanoma oncolysis through nonredundant death programs and associated with autophagy and pyroptosis proteins.
Q33285445The N-terminus and alpha-5, alpha-6 helices of the pro-apoptotic protein Bax, modulate functional interactions with the anti-apoptotic protein Bcl-xL.
Q39903945The amino-terminal peptide of Bax perturbs intracellular Ca2+ homeostasis to enhance apoptosis in prostate cancer cells.
Q37867486The calpain system and cancer.
Q34658476The calpain/calpastatin system has opposing roles in growth and metastatic dissemination of melanoma.
Q39005984The cellular autophagy/apoptosis checkpoint during inflammation
Q33726729The dual role of calcium as messenger and stressor in cell damage, death, and survival.
Q37310187The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family.
Q40606386The p18 truncated form of Bax behaves like a Bcl-2 homology domain 3-only protein
Q37142312The proteasome is a molecular target of environmental toxic organotins
Q39872718The protective effects and potential mechanism of Calpain inhibitor Calpeptin against focal cerebral ischemia-reperfusion injury in rats
Q38429588The role of excitotoxic programmed necrosis in acute brain injury

Search more.