Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis

scientific article published on 3 February 2017

Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BMC.2017.01.046
P932PMC publication ID5490664
P698PubMed publication ID28233680

P2093author name stringWei Chen
H Kim Lyerly
Jiangbo Wang
Larry S Barak
Xiu-Rong Ren
Robert A Mook
Hailan Piao
P2860cites workPhosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemiaQ24290495
Comprehensive molecular characterization of human colon and rectal cancerQ24630415
Wnt/beta-catenin signaling: components, mechanisms, and diseasesQ24630938
Uncouplers of oxidative phosphorylationQ24670385
Wnt/β-catenin signaling and diseaseQ26823272
Wnt/beta-catenin signaling in development and diseaseQ27860784
Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4Q28205234
Mechanism of action of reagents that uncouple oxidative phosphorylationQ28237551
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinaseQ28296225
Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathwayQ28478466
Niclosamide is a proton carrier and targets acidic endosomes with broad antiviral effectsQ28484821
Repurposing salicylanilide anthelmintic drugs to combat drug resistant Staphylococcus aureusQ28546591
A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]Q31106002
The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.Q33505762
Fasciolicides: efficacy, actions, resistance and its managementQ33733908
Multi-targeted therapy of cancer by niclosamide: A new application for an old drug.Q34199032
Growth inhibition of ovarian tumor-initiating cells by niclosamide.Q34265703
Small molecule modulators of Wnt/β-catenin signaling.Q34604768
Anticancer effects of niclosamide in human glioblastoma.Q34889036
Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in miceQ34988375
Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutationsQ35051128
Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancerQ35150756
Redeployment-based drug screening identifies the anti-helminthic niclosamide as anti-myeloma therapy that also reduces free light chain productionQ35664315
Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signalingQ36006981
Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposureQ36454906
Mining the Wnt pathway for cancer therapeuticsQ36670448
Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancerQ37227498
Effect of niclosamide on basal-like breast cancersQ37695022
Discovery of modulators of protein-protein interactions: current approaches and limitationsQ37841619
The potential of targeting Wnt/β-catenin in colon cancerQ38202202
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancerQ39001975
Inhibition of Wnt/β-catenin pathway by niclosamide: a therapeutic target for ovarian cancer.Q39003793
Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancerQ39522017
The biology and toxicology of molluscicides, BayluscideQ40254414
Mechanism of actin polymerization in cellular ATP depletionQ40615740
Activities of drug combinations against Mycobacterium tuberculosis grown in aerobic and hypoxic acidic conditionsQ41454109
Niclosamide Analogs for Treatment of Ovarian CancerQ41576087
Uncoupling: new approaches to an old problem of bioenergeticsQ41723090
New life for an old drug: the anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa quorum sensingQ42790739
Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen speciesQ43136797
The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cellsQ46152899
In vitro trypanocidal activity of the anti-helminthic drug niclosamideQ46786799
Salicylanilides: a new group of active uncouplers of oxidative phosphorylation.Q52471940
[Biological-chemical mechanism of action of an anti-cestode drug N-(2'-chloro-4'-nitrophenyl)-5-chloro-salicylamide. 1. Modification of enzyme systems]Q68453407
Niclosamide therapy for tapeworm infectionsQ70068227
ATP depletion rather than mitochondrial depolarization mediates hepatocyte killing after metabolic inhibitionQ72101322
The selection and use of essential medicinesQ80796505
6-Nitrobenzimidazole derivatives: potential phosphodiesterase inhibitors: synthesis and structure-activity relationshipQ83294987
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectniclosamideQ418523
chemotypeQ2212766
P304page(s)1804-1816
P577publication date2017-02-03
P1433published inBioorganic & Medicinal ChemistryQ2904200
P1476titleBenzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis
P478volume25

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cites work (P2860)
Q57074174Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth
Q90519433Identification of novel triazole inhibitors of Wnt/β-catenin signaling based on the Niclosamide chemotype
Q92074696Investigating Monoliths (Vinyl Azlactone-co-Ethylene Dimethacrylate) as a Support for Enzymes and Drugs, for Proteomics and Drug-Target Studies
Q57788799N-substituted phenylbenzamides of the niclosamide chemotype attenuate obesity related changes in high fat diet fed mice
Q39227540Niclosamide: Beyond an antihelminthic drug
Q55038918Preferential Inhibition of Wnt/β-Catenin Signaling by Novel Benzimidazole Compounds in Triple-Negative Breast Cancer.

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