S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.

scientific article published on 28 January 2017

S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.MOLCEL.2017.01.008
P932PMC publication ID5319395
P698PubMed publication ID28162934

P50authorAgata SmogorzewskaQ29839145
Lingmin YuanQ45918934
Shaun K OlsenQ54253067
Zongyang LvQ55163172
P2093author name stringBesim Ogretmen
Alec N Woosley
Philip H Howe
Kimberly A Rickman
Shanmugam Panneer Selvam
Katelyn Williams
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UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitinationQ24297826
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulationQ24300065
Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCIQ24311413
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Structural Insights into the Conformation and Oligomerization of E2∼Ubiquitin ConjugatesQ27678872
Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 SelectionQ27681171
Structure of the ubiquitin-activating enzyme loaded with two ubiquitin moleculesQ27690199
Coot: model-building tools for molecular graphicsQ27860505
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A flexible codon in genomically recoded Escherichia coli permits programmable protein phosphorylationQ28267103
E2s: structurally economical and functionally repleteQ28301074
Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chainsQ28594243
Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrateQ28740322
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Ubiquitin in motion: structural studies of the ubiquitin-conjugating enzyme∼ubiquitin conjugateQ34666396
The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteinsQ35014611
Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemiaQ35689795
Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi AnemiaQ35836818
Activation of UbcH5c~Ub is the result of a shift in interdomain motions of the conjugate bound to U-box E3 ligase E4B.Q36882621
What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor?Q37215638
The courtship of proteins: understanding the encounter complexQ37411740
Structural insights into the catalysis and regulation of E3 ubiquitin ligasesQ38916854
Molecular basis for lysine specificity in the yeast ubiquitin-conjugating enzyme Cdc34.Q40337840
Human Cdc34 employs distinct sites to coordinate attachment of ubiquitin to a substrate and assembly of polyubiquitin chainsQ42067617
The loop-less tmCdc34 E2 mutant defective in polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2.Q42720645
Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34.Q46711534
SnapShot: Fanconi anemia and associated proteins.Q55058813
P4510describes a project that usesImageJQ1659584
P433issue4
P304page(s)699-714.e6
P577publication date2017-02-02
P1433published inMolecular CellQ3319468
P1476titleS. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity
P478volume65

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cites work (P2860)
Q57046930Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity
Q91173854Differential Inhibition of Human and Trypanosome Ubiquitin E1S by TAK-243 Offers Possibilities for Parasite Selective Inhibitors
Q38749959Domain alternation and active site remodeling are conserved structural features of ubiquitin E1.
Q57471364Generation and characterization of functional phosphoserine-incorporated neuronal nitric oxide synthase holoenzyme
Q59794218Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
Q92998759Structural basis for adenylation and thioester bond formation in the ubiquitin E1
Q92153523Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34
Q98513852Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer
Q93241593UFM1-Activating Enzyme 5 (Uba5) Requires an Extension to Get the Job Done Right

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