Oxidation of Z α1-antitrypsin by cigarette smoke induces polymerization: a novel mechanism of early-onset emphysema. (scientific article published on 22 October 2010)

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

Q29618777

Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages

Q34198111

Alpha1-antitrypsin deficiency. 1: epidemiology of alpha1-antitrypsin deficiency

Q34294602

The Z type variation of human alpha 1-antitrypsin causes a protein folding defect

Q34304294

Alpha1-antitrypsin deficiency

Q34428996

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

Q34440939

Clinical practice. Alpha1-antitrypsin deficiency

Q34988812

Worldwide racial and ethnic distribution of alpha1-antitrypsin deficiency: summary of an analysis of published genetic epidemiologic surveys

Q34993988

Chronic obstructive pulmonary disease: molecular and cellularmechanisms

Q35569962

Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase

Q35581750

Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo

Q35755014

Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice

Q35843301

Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity

Q36288052

Oxidative regulation of neutrophil elastase-alpha-1-proteinase inhibitor interactions

Q36994626

National Emphysema Treatment Trial state of the art: genetics of emphysema

Q37103683

Oxidized {alpha}1-antitrypsin stimulates the release of monocyte chemotactic protein-1 from lung epithelial cells: potential role in emphysema

Q37343918

Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages

Q40125369

Cigarette Smoking Induces Functional Antiprotease Deficiency in the Lower Respiratory Tract of Humans

Q40730350

Heteropolymerization of S, I, and Z alpha1-antitrypsin and liver cirrhosis.

Q40850434

Lung polymers in Z alpha1-antitrypsin deficiency-related emphysema

Q42454527

Polymers of alpha(1)-antitrypsin are chemotactic for human neutrophils: a new paradigm for the pathogenesis of emphysema

Q42521815

6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis

Q43843392

Evaluation of oxidized alpha-1-antitrypsin in blood as an oxidative stress marker using anti-oxidative alpha1-AT monoclonal antibody

Q43868643

Oxidation of alpha1-proteinase inhibitor by the myeloperoxidase-hydrogen peroxidase system promotes binding to immunoglobulin A.

Q45856708

Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant

Q47622881

The mechanism of alpha 1-antitrypsin polymerization probed by fluorescence spectroscopy

Q47683107

Decline in pulmonary function in patients with alpha 1-antitrypsin deficiency.

Q50550743

A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

Q57980265

P433

issue

P304

page(s)

261-269

P577

publication date

2010-10-22

P1433

published in

American Journal of Respiratory Cell and Molecular Biology

Q4744268

P1476

title

Oxidation of Z α1-antitrypsin by cigarette smoke induces polymerization: a novel mechanism of early-onset emphysema.

P478

volume

Reverse relations

cites work (P2860)

Q27343637	Active trafficking of alpha 1 antitrypsin across the lung endothelium
Q56243502	Advances in managing COPD related to α -antitrypsin deficiency: An under-recognized genetic disorder
Q38114852	Alpha-1 antitrypsin deficiency: new developments in augmentation and other therapies
Q55666746	Alpha-1 antitrypsin deficiency: outstanding questions and future directions.
Q26995192	Alpha-1-antitrypsin deficiency
Q38937853	An ECLIPSE View of Alpha-1 Antitrypsin Deficiency
Q37986343	Antioxidant pharmacological therapies for COPD.
Q55315240	Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes.
Q36549080	Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization
Q36115364	Division of labor among oxidoreductases: TMX1 preferentially acts on transmembrane polypeptides
Q35973238	Effect of cigarette smoke exposure and structural modifications on the α-1 Antitrypsin interaction with caspases
Q38937862	Gene Therapy for Alpha-1 Antitrypsin Deficiency Lung Disease
Q24630805	Genes and chronic obstructive pulmonary disease
Q64284276	Identifying Alpha-1 Antitrypsin Deficiency Based on Computed Tomography Evidence of Emphysema
Q47643314	Impact of HIV Infection on Alpha-1 Antitrypsin in the Lung
Q39085645	Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin
Q33880491	Inflammatory cytokine response to exercise in alpha-1-antitrypsin deficient COPD patients 'on' or 'off' augmentation therapy.
Q64964706	Intrapleural Gene Therapy for Alpha-1 Antitrypsin Deficiency-Related Lung Disease.
Q90585448	Lectin Complement Pathway in Emphysema
Q51596330	Nano zerovalent iron particles induce pulmonary and cardiovascular toxicity in an in vitro human co-culture model.
Q39704142	Oxidative Stress and Polymorphism of Xenobiotic-Metabolizing Enzymes in Two Patients with Severe Alpha-1-Antitrypsin Deficiency
Q37217006	REDOX IMBALANCE IN LUNG CANCER OF PATIENTS WITH UNDERLYING CHRONIC RESPIRATORY CONDITIONS.
Q63246374	Recent Developments in mRNA-Based Protein Supplementation Therapy to Target Lung Diseases
Q38988633	Recent advances in understanding and treating COPD related to α1-antitrypsin deficiency
Q28077681	Relationships between chronic obstructive pulmonary disease and lung cancer: biological insights
Q28387428	SERPINA1 PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort
Q36386977	Secretomic analysis identifies alpha-1 antitrypsin (A1AT) as a required protein in cancer cell migration, invasion, and pericellular fibronectin assembly for facilitating lung colonization of lung adenocarcinoma cells
Q59130095	The Interplay Between Immune Response and Bacterial Infection in COPD: Focus Upon Non-typeable
Q57119419	Therapeutic potential of alpha-1 antitrypsin in human disease
Q35214289	Therapeutic targeting of misfolding and conformational change in α1-antitrypsin deficiency
Q35031693	Therapy with plasma purified alpha1-antitrypsin (Prolastin®) induces time-dependent changes in plasma levels of MMP-9 and MPO.
Q38092851	Twenty years of polymers: a personal perspective on alpha-1 antitrypsin deficiency
Q61044333	Update on α-antitrypsin deficiency
Q51465416	Well-Known and Less Well-Known Functions of Alpha-1 Antitrypsin. Its Role in Chronic Obstructive Pulmonary Disease and Other Disease Developments.
Q35233352	Why has it been so difficult to prove the efficacy of alpha-1-antitrypsin replacement therapy? Insights from the study of disease pathogenesis
Q33901639	Z α1-antitrypsin confers a proinflammatory phenotype that contributes to chronic obstructive pulmonary disease

P356	DOI	10.1165/RCMB.2010-0328OC
P698	PubMed publication ID	20971880