An ECLIPSE View of Alpha-1 Antitrypsin Deficiency

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An ECLIPSE View of Alpha-1 Antitrypsin Deficiency is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1513/ANNALSATS.201506-348KV
P698PubMed publication ID27564668

P2093author name stringDavid A Lomas
P2860cites workGlobal Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary DiseaseQ22299313
Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregatesQ24645055
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Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysisQ35536791
COPD association and repeatability of blood biomarkers in the ECLIPSE cohortQ35637295
Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivoQ35755014
Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiencyQ35837259
COPD, a multicomponent disease: implications for managementQ36119043
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Blood fibrinogen as a biomarker of chronic obstructive pulmonary diseaseQ37012728
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New Findings in PiZZ alpha1-antitrypsin deficiency-related panniculitis. Demonstration of skin polymers and high dosing requirements of intravenous augmentation therapyQ37466723
Club cell protein 16 and disease progression in chronic obstructive pulmonary diseaseQ37566520
Lessons from ECLIPSE: a review of COPD biomarkersQ38169066
C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary diseaseQ40277494
Quantitative isolation of alphalAT mutant Z protein polymers from human and mouse livers and the effect of heatQ40518358
Lung polymers in Z alpha1-antitrypsin deficiency-related emphysemaQ42454527
Polymers of alpha(1)-antitrypsin are chemotactic for human neutrophils: a new paradigm for the pathogenesis of emphysemaQ42521815
Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary diseaseQ43779676
The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE studyQ43875548
Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD.Q46150950
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Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractantQ47622881
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Exacerbations in {alpha}1-antitrypsin deficiencyQ47787819
Should we view chronic obstructive pulmonary disease differently after ECLIPSE? A clinical perspective from the study team.Q51159286
Changes in forced expiratory volume in 1 second over time in COPD.Q51521679
Oxidation of Z α1-antitrypsin by cigarette smoke induces polymerization: a novel mechanism of early-onset emphysema.Q51536039
Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease.Q53409072
Systemic Inflammation and COPDQ57072926
Inflammatory Biomarkers Improve Clinical Prediction of Mortality in Chronic Obstructive Pulmonary DiseaseQ57955696
Susceptibility to Exacerbation in Chronic Obstructive Pulmonary DiseaseQ57955820
Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE)Q57955885
Evaluation of serum CC-16 as a biomarker for COPD in the ECLIPSE cohortQ58316998
Circulating polymers in 1-antitrypsin deficiencyQ58966863
ANCA-associated vasculitis is linked to carriage of the Z allele of 1 antitrypsin and its polymersQ58967026
P304page(s)S326-31
P577publication date2016-08-01
P1433published inProceedings of the American Thoracic SocietyQ7247176
P1476titleAn ECLIPSE View of Alpha-1 Antitrypsin Deficiency
P478volume13 Suppl 4

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cites work (P2860)
Q55666746Alpha-1 antitrypsin deficiency: outstanding questions and future directions.
Q55689873Cigarette smoke extract enhances neutrophil elastase-induced IL-8 production via proteinase-activated receptor-2 upregulation in human bronchial epithelial cells.
Q39173207Double-hit mouse model of cigarette smoke priming for acute lung injury
Q29091067Network biology concepts in complex disease comorbidities

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