Cigarette smoke extract enhances neutrophil elastase-induced IL-8 production via proteinase-activated receptor-2 upregulation in human bronchial epithelial cells.

scientific article published on 6 July 2018

Cigarette smoke extract enhances neutrophil elastase-induced IL-8 production via proteinase-activated receptor-2 upregulation in human bronchial epithelial cells. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1105340377
P356DOI10.1038/S12276-018-0114-1
P2888exact matchhttps://scigraph.springernature.com/pub.10.1038/s12276-018-0114-1
P932PMC publication ID6035212
P698PubMed publication ID29980681

P2093author name stringChang-Hoon Lee
Chul-Gyu Yoo
Jinwoo Lee
Jiyeong Jeong
Kyoung-Hee Lee
Jisu Woo
P2860cites workPathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammationQ24615052
Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cellsQ28208613
Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cellsQ33799418
Signal transduction by protease-activated receptorsQ33870369
Low-concentration hydrogen peroxide can upregulate keratinocyte intracellular calcium and PAR-2 expression in a human keratinocyte-melanocyte co-culture system.Q51410860
House dust mite allergen suppresses neutrophil apoptosis by cytokine release via PAR2 in normal and allergic lymphocytes.Q52895485
Imbalance of apoptosis and cell proliferation contributes to the development and persistence of emphysema.Q53211563
Clinical implication of protease-activated receptor-2 in idiopathic pulmonary fibrosis.Q53354513
Quantitative analysis of the hydrogen peroxide formed in aqueous cigarette tar extractsQ69665738
Severity of airflow limitation is associated with severity of airway inflammation in smokersQ77400204
Protease-activated receptor-2 (PAR-2) expression in human fibroblasts is regulated by growth factors and extracellular matrixQ80857298
[Human lung epithelial cells produce interleukin-8 through protease-activated receptor 1]Q81083858
[Neutrophils and macrophages related to the pathogenesis and disease development of chronic obstructive pulmonary disease by the inflammatory reaction]Q82456065
Protease-activated receptor-2 (PAR2) in the airwaysQ34305483
Inflammation in sputum relates to progression of disease in subjects with COPD: a prospective descriptive studyQ35171918
Expression of protease activated receptor-2 (PAR-2) in central airways of smokers and non-smokers.Q35534960
Inflammatory cells in the airways in COPD.Q36203075
Neutrophil Elastase Differentially Regulates Interleukin 8 (IL-8) and Vascular Endothelial Growth Factor (VEGF) Production by Cigarette Smoke ExtractQ36301335
Mechanisms of cigarette smoke-induced COPD: insights from animal modelsQ37068538
The dual role of neutrophil elastase in lung destruction and repair.Q37075255
Neutrophils and emerging targets for treatment in chronic obstructive pulmonary disease.Q38156225
Exogenous neutrophil elastase enters bronchial epithelial cells and suppresses cigarette smoke extract-induced heme oxygenase-1 by cleaving sirtuin 1.Q38701061
Does Protease-Antiprotease Imbalance Explain Chronic Obstructive Pulmonary Disease?Q38817967
An ECLIPSE View of Alpha-1 Antitrypsin DeficiencyQ38937853
Chronic obstructive pulmonary disease and neutrophil infiltration: role of cigarette smoke and cyclooxygenase productsQ39777516
PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cellsQ39929499
Signal transduction for formation/release of interleukin-8 caused by a PAR2-activating peptide in human lung epithelial cellsQ40081234
Protease-activated receptor-2 induces myofibroblast differentiation and tissue factor up-regulation during bleomycin-induced lung injury: potential role in pulmonary fibrosisQ41459860
Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase beta in human endothelial cellsQ41585571
Upregulation of proteinase-activated receptor-2 and increased response to trypsin in endothelial cells after exposure to oxidative stress in rat aortasQ43079183
The effect of tobacco ingredients on smoke chemistry. Part I: Flavourings and additivesQ44836319
Functional inhibition of PAR2 alleviates allergen-induced airway hyperresponsiveness and inflammation.Q45980761
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue7
P304page(s)79
P577publication date2018-07-06
P1433published inExperimental and Molecular MedicineQ15758292
P1476titleCigarette smoke extract enhances neutrophil elastase-induced IL-8 production via proteinase-activated receptor-2 upregulation in human bronchial epithelial cells.
P478volume50

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Q93140318Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide‑induced pulmonary inflammation by inhibiting interleukin‑8 production and NF‑κB activationcites workP2860

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