Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily.

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Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3109/00498259609050260
P698PubMed publication ID8948091

P2093author name stringF J Gonzalez
T Satoh
S Miyazawa
S Ono
T Aoyama
T Hatanaka
M Tsutsui
P2860cites workEvidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humansQ24323988
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Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liverQ28243581
The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomesQ28281124
Biochemistry and molecular biology of the human CYP2C subfamilyQ28299258
Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1Q33645193
Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoformsQ34346567
Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populationsQ34695612
cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liverQ35570503
Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and manQ35580014
Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytesQ35608569
Genetic polymorphism of S-mephenytoin hydroxylationQ38692055
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclatureQ40484461
Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomesQ41187611
Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactionsQ44735365
Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics.Q51686117
Diazepam metabolism by rat and human liver in vitro: inhibition by mephenytoinQ51692236
Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.Q51755470
Determination of diazepam and oxazepam using high-performance liquid chromatography and fourth-derivative spectrophotometric techniques.Q51767867
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectdiazepamQ210402
P304page(s)1155-1166
P577publication date1996-11-01
P1433published inXenobioticaQ1360678
P1476titleHuman liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily.
P478volume26

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