Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives

scientific article published on June 1999

Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/0264-6021:3400845
P932PMC publication ID1220319
P698PubMed publication ID10359672
P5875ResearchGate publication ID12938635

P2093author name stringBaillie TA
Dai R
Rushmore TH
Shou M
Mei Q
Ettore MW Jr
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The active sites of cytochromes P450 IA1, IIB1, IIB2, and IIE1. Topological analysis by in situ rearrangement of phenyl-iron complexesQ44385054
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Diazepam metabolism by cDNA-expressed human 2C P450s: identification of P4502C18 and P4502C19 as low K(M) diazepam N-demethylases.Q51549688
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Characterization of specific cytochrome P450 enzymes responsible for the metabolism of diazepam in hepatic microsomes of adult male rats.Q51673373
Metabolism of diazepam and related benzodiazepines by human liver microsomes.Q51699901
[Interaction of coumarin-hydroxylating cytochrome P-450coh from liver microsomes of mice induced by pyrazole with cytochrome b5]Q68357443
The interaction of cytochrome b5 with four cytochrome P-450 enzymes from the untreated ratQ69868236
Purification and characterization of six cytochrome P-450 isozymes from human liver microsomesQ70458093
N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitorsQ71513231
Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formationQ72014034
Cytochrome P450 conformation and substrate interactions as probed by CO binding kineticsQ73017807
Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sitesQ74378005
KINETICS OF REGULATORY ENZYMES. KINETIC ORDER OF THE YEAST DIPHOSPHOPYRIDINE NUCLEOTIDE ISOCITRATE DEHYDROGENASE REACTION AND A MODEL FOR THE REACTIONQ78405723
P407language of work or nameEnglishQ1860
P921main subjectdiazepamQ210402
P1104number of pages9
P304page(s)845-853
P577publication date1999-06-01
P1433published inBiochemical JournalQ864221
P1476titleSigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives
P478volume340 ( Pt 3)

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