Enzymatic oxidation of xenobiotic chemicals

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Enzymatic oxidation of xenobiotic chemicals is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3109/10409239009090607
P698PubMed publication ID2183970
P5875ResearchGate publication ID20972026

P2093author name stringGuengerich FP
P2860cites workHuman liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzymeQ24297544
Human liver MAO-A and MAO-B separated by immunoaffinity chromatography with MAO-B-specific monoclonal antibodyQ24302426
cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic propertiesQ24647273
High-resolution crystal structure of cytochrome P450camQ27728724
GlutathioneQ28261279
Metabolic oxidation of acetaminophen (paracetamol) mediated by cytochrome P-450 mixed-function oxidase and prostaglandin endoperoxide synthetase in rabbit kidneyQ28273910
Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylaseQ28292662
Impaired oxidation of debrisoquine in patients with perhexiline neuropathyQ28366143
cDNA and protein structure for the alpha subunit of human liver alcohol dehydrogenaseQ28633684
Oxidation of substituted N,N-dimethylanilines by cytochrome P-450: estimation of the effective oxidation-reduction potential of cytochrome P-450.Q30458479
Molecular cloning of complementary DNA encoding the lignin-forming peroxidase from tobacco: Molecular analysis and tissue-specific expressionQ33238827
Transformation of thebaine to oripavine, codeine, and morphine by rat liver, kidney, and brain microsomesQ33554609
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequenceQ33555966
N-methylation: potential mechanism for metabolic activation of carcinogenic primary arylaminesQ33566671
Proteins from eight eukaryotic cytochrome P-450 families share a segmented region of sequence similarityQ33651405
Cloning and sequencing of a cDNA for a ligninase from Phanerochaete chrysosporiumQ34050204
Role of molecular oxygen in lignin peroxidase reactionsQ34050655
Arachidonic acid-dependent metabolism of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by ram seminal vesiclesQ43448200
Transformations of arylpropane lignin model compounds by a lignin peroxidase of the white-rot fungus Phanerochaete chrysosporiumQ43459645
Characterization of the omega-hydroxylase of Pseudomonas oleovorans as a nonheme iron proteinQ43500009
Peroxidase-catalyzed N-demethylation reactions: deuterium solvent isotope effectsQ43583524
Comparison of rates of enzymatic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responsesQ43705605
Separation of two monoamine oxidases from bovine branQ44412462
A single amino acid substitution converts cytochrome P450(14DM) to an inactive form, cytochrome P450SG1: complete primary structures deduced from cloned DNAS.Q44418687
Effect of substrate on the spin state of cytochrome P-450 in hepatic microsomesQ45182076
Spectral intermediates in the reaction of oxygen with purified liver microsomal cytochrome P-450Q45196209
Interactions of diethylphenylphosphine with purified, reconstituted mouse liver cytochrome P-450 monooxygenase systemsQ45232704
Degradation of rat hepatic cytochrome P-450 heme by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine to irreversibly bound protein adducts.Q45996347
Oxidation of (+)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by mouse keratinocytes: evidence for peroxyl radical- and monoxygenase-dependent metabolismQ46730711
Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequenceQ48325388
Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidaseQ48681443
Kinetic studies and effects in vivo of a new monoamine oxidase inhibitor, N[2(ochlorophenoxy)-ethyl]-cyclopropylamineQ49141001
The P450 gene superfamily: recommended nomenclature.Q50709368
Purification of the flavin-containing monooxygenase from mouse and pig liver microsomes.Q50925338
The purification of pig brain mitochondrial monoamine oxidase.Q51189508
The sub-mitochondrial localization of monoamine oxidase in rat liver and brain.Q51224402
Covalent binding to apoprotein is a major fate of heme in a variety of reactions in which cytochrome P-450 is destroyed.Q51806191
On the mechanism of the peroxidase-catalyzed oxygen-transfer reaction.Q52590651
Stopped-flow studies on the mechanism of oxidation of N-methyl-4-phenyltetrahydropyridine by bovine liver monoamine oxidase B.Q52594583
3-Phenylpropenes as mechanism-based inhibitors of dopamine beta-hydroxylase: evidence for a radical mechanism.Q52671978
Reducing substrate activity of some aromatic amines for prostaglandin H synthase.Q53530709
Prostaglandin H synthase-dependent epoxidation of aflatoxin B1.Q53542844
Prostaglandin H synthase-dependent co-oxygenation of (+/-)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in hamster trachea and human bronchus explants.Q53551773
Purification of mixed-function amine oxidase from rat liver microsomes.Q53561036
Mechanism for reactivation of N-cyclopropylbenzylamine-inactivated monoamine oxidase by amines.Q53741439
A new spectral intermediate associated with cytochrome P-450 function in liver microsomes.Q53876638
3-(Trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine photolabels a substrate-binding site of rat hepatic cytochrome P-450 form PB-4.Q54423911
Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs.Q55060683
Dopamine beta-hydroxylase of adrenal chromaffin granules: structure and functionQ34164175
Biochemistry of metallothioneinQ34164847
Prostaglandin H synthase: distinct binding sites for cyclooxygenase and peroxidase substratesQ34167660
Oxotransition metal oxidants as mimics for the action of mixed-function oxygenases. "NIH shift" with chromyl reagentsQ34235771
Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseasesQ34256779
Aldehyde dehydrogenase from human liver. Primary structure of the cytoplasmic isoenzymeQ34267380
Purification and characterization of cysteine conjugate transaminases from rat liverQ34556957
Ferric chloride-catalyzed activation of hydrogen peroxide for the demethylation of N,N-dimethylaniline, the epoxidation of olefins, and the oxidative cleavage of vicinal diols in acetonitrile: a reaction mimic for cytochrome P-450Q34607001
Metabolism of aromatic amines by prostaglandin H synthaseQ35035594
cDNA and complete amino acid sequence of mouse P2(450): allelic variant of mouse P3(450) geneQ35050194
Flavin and 5-deazaflavin: A chemical evaluation of ‘modified’ flavoproteins with respect to the mechanisms of redox biocatalysisQ35555132
Substrate free radicals are intermediates in ligninase catalysisQ35607625
Presence and formation of codeine and morphine in the ratQ35612868
The possibility that the spectrum of intermediate two, seen in the course of reaction of flavoenzyme phenol hydroxylases, may be attributable to iminol isomers of a flavin-derived 6-arylamino-5-oxo(3H,5H)uracilQ36246601
Cytochrome P-450 related to P-4504 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cellsQ36283602
Human dopamine beta-hydroxylase gene: two mRNA types having different 3'-terminal regions are produced through alternative polyadenylationQ36417592
Crystallization of cytochrome P-450scc from bovine adrenocortical mitochondriaQ36452949
Complete amino acid sequence and predicted membrane topology of phenobarbital-induced cytochrome P-450 (isozyme 2) from rabbit liver microsomesQ37521927
Stabilization of higher-valent states of iron porphyrin by hydroxide and methoxide ligands: electrochemical generation of iron(IV)-oxo porphyrinsQ37522188
Morphine and other opiates from beef brain and adrenalQ37526607
On the mechanisms of induction of cancer-protective enzymes: a unifying proposalQ37558012
Isolation of morphine from toad skinQ37681014
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicityQ37683630
Interactions of monoamine oxidase with substrates and inhibitorsQ38601497
The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal lociQ38618586
Characterization of human microsomal cytochrome P-450 enzymesQ38639934
Comparison of the metabolism of benzo[a]pyrene and binding to DNA caused by rat liver nuclei and microsomesQ39081155
Cytochrome P450 as an oxene transferaseQ39102085
Changes of mechanisms and product distributions in the hydrolysis of benzo[a]pyrene-7,8-diol 9,10,-epoxide metabolites induced by changes in pHQ39155872
Destruction of heme and hemoproteins mediated by liver microsomal reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductaseQ39207182
Highly purified microsomal P-450: The oxyferro intermediate stabilized at low temperatureQ39267690
Pharmacogenetics of methylation: relationship to drug metabolismQ39518037
DNA repair in genesQ39542919
Endogenous substrates for UDP-glucuronosyltransferasesQ39609883
Mechanism of the neurotoxicity of 1-methyl-4-phenylpyridinium (MPP+), the toxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).Q39643835
The metabolic basis for combination chemotherapyQ39652688
Flavin-containing monooxygenases: catalytic mechanism and substrate specificitiesQ39654203
P450 genes: structure, evolution, and regulationQ39664988
Metabolism and reactions of alkylating agentsQ39691866
Kinetic isotope effects and 'metabolic switching' in cytochrome P450-catalyzed reactionsQ39693446
Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholismQ39733913
An update on the identity crisis of monoamine oxidase: new and old evidence for the independence of MAO A and B.Q39843930
Enzymatic activation of chemicals to toxic metabolites.Q39847955
Isolation from bovine liver mitochondria of a soluble ferredoxin active in a reconstituted steroid hydroxylation reactionQ40096645
Vitamin D: recent advancesQ40137018
Chemical Mechanisms of Halocarbon MetabolismQ40147765
Suicidal destruction of cytochrome P-450 during oxidative drug metabolismQ40152926
Xenobiotic metabolism by prostaglandin endoperoxide synthetaseQ40210070
Models for ferric cytochrome P450. Characterization of hemin mercaptide complexes by electronic and ESR spectraQ40275383
Oxygen activation by cytochrome P-450.Q40289289
Oxygenase-catalyzed biological hydroxylationsQ40690254
Differences in mutagenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxidesQ40808035
Nuclear Activation of Polycyclic HydrocarbonsQ41201277
Prostagland in synthetase dependent benzo(a)pyrene oxidation: Products of the oxidation and inhibition of their formation by antioxidantsQ41346686
Lignin peroxidase: resonance Raman spectral evidence for compound II and for a temperature-dependent coordination-state equilibrium in the ferric enzymeQ41372672
4-alkyl radical extrusion in the cytochrome P-450-catalyzed oxidation of 4-alkyl-1,4-dihydropyridinesQ41408857
Inactivation of dopamine beta-hydroxylase by p-cresol: isolation and characterization of covalently modified active site peptidesQ41418608
Iodosylbenzene derivatives as oxygen donors in cytochrome P-450 catalyzed steroid hydroxylationsQ41439521
Synthesis of the skeleton of the morphine molecule by mammalian liverQ41466253
Determination of the membrane topology of the phenobarbital-inducible rat liver cytochrome P-450 isoenzyme PB-4 using site-specific antibodiesQ41514139
Olefin oxidation by cytochrome P-450: evidence for group migration in catalytic intermediates formed with vinylidene chloride and trans-1-phenyl-1-buteneQ41589786
Oxidation of trichloroethylene by liver microsomal cytochrome P-450: evidence for chlorine migration in a transition state not involving trichloroethylene oxideQ41620925
25-Hydroxylation of vitamin D3 by a cytochrome P-450 from rabbit liver mitochondriaQ42164193
Participation of cytochrome P-450 isozymes in N-demethylation, N-hydroxylation and aromatic hydroxylation of methamphetamineQ42209001
Mechanism of formation and structural characterization of DNA adducts derived from peroxidative activation of benzidineQ42209031
Bioactivation of MPTP: reactive metabolites and possible biochemical sequelaeQ42216518
A genetic polymorphism of the N-oxidation of trimethylamine in humansQ42220150
Inactivation of cytochrome P-450 by 2-isopropyl-4-pentenamide and other xenobiotics leads to heme-derived protein adducts.Q42221739
Studies on the 1-methyl-4-phenyl-2,3-dihydropyridinium species 2,3-MPDP+, the monoamine oxidase catalyzed oxidation product of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).Q42224907
Characterization of the enzymatic and nonenzymatic peroxidative degradation of iron porphyrins and cytochrome P-450 hemeQ42226013
Carbon tetrachloride and 2-isopropyl-4-pentenamide-induced inactivation of cytochrome P-450 leads to heme-derived protein adductsQ42226618
Destruction of cytochrome P-450 by vinyl fluoride, fluroxene, and acetylene. Evidence for a radical intermediate in olefin oxidationQ42241514
Chemical Mutation of Enzyme Active SitesQ42244435
Metabolic activation of the carcinogen N-[4-(5-nitro-2-furyl)-2-thiazolyl]acetamide by prostaglandin H synthaseQ42249301
Rabbit lung flavin-containing monooxygenase is immunochemically and catalytically distinct from the liver enzymeQ42249402
Effect of alpha-methylation on inactivation of monoamine oxidase by N-cyclopropylbenzylamineQ42250963
Inhibition by aspirin of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide-induced bladder carcinogenesis and enhancement of forestomach carcinogenesisQ42255167
Dopamine-B-hydroxylase: suicide inhibition by the novel olefinic substrate, 1-phenyl-1-aminomethyletheneQ42259898
Alkylation of the prosthetic heme in cytochrome P-450 during oxidative metabolism of the sedative-hypnotic ethchlorvynolQ42265519
Prostaglandin hydroperoxidase-catalyzed activation of certain N-substituted aryl renal and bladder carcinogensQ43235620
P433issue2
P304page(s)97-153
P577publication date1990-01-01
P1433published inCritical Reviews in Biochemistry and Molecular BiologyQ5186661
P1476titleEnzymatic oxidation of xenobiotic chemicals
P478volume25

Reverse relations

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