Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation.

scientific article published in April 2009

Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/EJI.200838904
P698PubMed publication ID19283780
P5875ResearchGate publication ID24198542

P50authorMatthias EdingerQ51013955
P2093author name stringJochen Huehn
Wolfgang Dietmaier
Stefan Floess
Petra Hoffmann
Sven Olek
Reinhard Andreesen
Ruediger Eder
Tina J Boeld
Georg Wieczorek
P2860cites workEpigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signalsQ22122053
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repressionQ24300168
Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cellsQ24645614
Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylationQ28587503
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cellsQ29618394
Epigenetic control of the foxp3 locus in regulatory T cellsQ33273617
A peripheral circulating compartment of natural naive CD4 TregsQ33865874
Cutting edge: cure of colitis by CD4+CD25+ regulatory T cellsQ34189120
CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host diseaseQ34525987
Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune diseaseQ34556560
OX40 costimulation turns off Foxp3+ Tregs.Q36007580
Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotypeQ36059631
Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cellsQ36228688
CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation.Q36229540
Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in miceQ36249529
Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantationQ36370863
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetesQ36399048
Foxp3 in control of the regulatory T cell lineageQ36794299
Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans.Q36891917
Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor functionQ40514795
Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells.Q40565739
Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo.Q40643930
CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantationQ44408941
Dynamic regulation of FoxP3 expression controls the balance between CD4+ T cell activation and cell deathQ44914986
What does the future hold for cell-based tolerogenic therapy?Q46228704
Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.Q51980108
Persistence of naive CD45RA+ regulatory T cells in adult life.Q51986549
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.Q51997055
DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.Q52924279
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expressionQ59048389
Regulatory T cells in transplantationQ61651648
Simultaneous evaluation of T- and B-cell clonality, t(11;14) and t(14;18), in a single reaction by a four-color multiplex polymerase chain reaction assay and automated high-resolution fragment analysis: a method for the rapid molecular diagnosis ofQ77321810
The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethalityQ78033315
Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-betaQ80358435
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1088-1097
P577publication date2009-04-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleLoss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation.
P478volume39

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cites work (P2860)
Q52725822A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials.
Q35088234A novel cellular senescence gene, SENEX, is involved in peripheral regulatory T cells accumulation in aged urinary bladder cancer
Q28727355Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation
Q41233136Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice
Q52595727Alloantigen-specific de novo-induced Foxp3+ Treg revert in vivo and do not protect from experimental GVHD.
Q34046489Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor
Q27028000An immunologic portrait of cancer
Q43733156Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi.
Q61803775Automated Clinical Grade Expansion of Regulatory T Cells in a Fully Closed System
Q40366439Azacytidine Treatment Inhibits the Progression of Herpes Stromal Keratitis by Enhancing Regulatory T Cell Function
Q52966824C-terminal cleavage of human Foxp3 at a proprotein convertase motif abrogates its suppressive function.
Q50281162CD137+CD154- Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures.
Q46762458CD26: a negative selection marker for human Treg cells
Q37968576CD4(+)Foxp3(+) regulatory T cell therapy in transplantation
Q97523291CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells
Q39279238Cell Therapy in Kidney Transplantation: Focus on Regulatory T Cells
Q33778359Characterization of protective human CD4CD25 FOXP3 regulatory T cells generated with IL-2, TGF-β and retinoic acid
Q38201742Clinical management of patients receiving cell-based immunoregulatory therapy.
Q37912653Clinical perspectives for regulatory T cells in transplantation tolerance
Q34440616Clues to immune tolerance: the monogenic autoimmune syndromes
Q91660080Coexpression of FOXP3 and a Helios isoform enhances the effectiveness of human engineered regulatory T cells
Q47118146Combination of IL-2, rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells
Q43160329Comment on "Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells" Haematologica 2011;96(9):1357-65.
Q35195777Comparative approach to define increased regulatory T cells in different cancer subtypes by combined assessment of CD127 and FOXP3.
Q34082794Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions
Q34994485Cutting edge: all-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu.
Q39029665Cytotoxic response of human regulatory T cells upon T-cell receptor-mediated activation: a matter of purity
Q35693630Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria
Q37420224Detection of Foreign Antigen-specific CD4(+)Foxp3(+) Regulatory T Cells by MHC Class II Tetramer and Intracellular CD154 Staining
Q28601365Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease
Q89748559Distinct microbial and immune niches of the human colon
Q35762695Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226.
Q34046493Driving allotolerance: CAR-expressing Tregs for tolerance induction in organ and stem cell transplantation.
Q91260567Efficient treatment of murine acute GvHD by in vitro expanded donor regulatory T cells
Q45875046Engineering Specificity and Function of Therapeutic Regulatory T Cells.
Q37412329Epigenetic mechanisms of regulation of Foxp3 expression
Q51013890Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naïve Treg.
Q37962599Epigenomics in hematopoietic transplantation: novel treatment strategies
Q34424570Ex Vivo Expanded Autologous Polyclonal Regulatory T Cells Suppress Inhibitor Formation in Hemophilia.
Q35252405Ex vivo-expanded but not in vitro-induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the FOXP3 regulatory T cell-specific demethylated region.
Q54236063Expression of Ets-1 and FOXP3 mRNA in CD4(+)CD25 (+) T regulatory cells from patients with systemic lupus erythematosus.
Q29307487FOXP3+ regulatory T cells in the human immune system
Q54473462Flt3 ligand expands CD4+ FoxP3+ regulatory T cells in human subjects.
Q38124117Forkhead Box P family members at the crossroad between tolerance and immunity: a balancing act.
Q38172563Forkhead box P3: the peacekeeper of the immune system.
Q47914208Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments.
Q38000883Functional plasticity in human FOXP3(+) regulatory T cells: implications for cell-based immunotherapy
Q92714308Functions of T-cell subsets and their related cytokines in the pathological processes of autoimmune encephalomyelitic mice
Q35815893HY-Specific Induced Regulatory T Cells Display High Specificity and Efficacy in the Prevention of Acute Graft-versus-Host Disease
Q51539858Hepatic stellate cells increase the immunosuppressive function of natural Foxp3+ regulatory T cells via IDO-induced AhR activation.
Q36388771Heterogeneity and plasticity of T helper cells
Q40145396Histone methylation mediates plasticity of human FOXP3(+) regulatory T cells by modulating signature gene expressions
Q33644234Human Antigen-Specific Regulatory T Cells Generated by T Cell Receptor Gene Transfer
Q34626852Human FoxP3(+)CD4(+) regulatory T cells: their knowns and unknowns
Q34384366Human regulatory T cells in autoimmune diseases
Q53212253Human regulatory T cells suppress proliferation of B lymphoma cells.
Q34614309Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC.
Q54427491Human tumor antigen-specific helper and regulatory T cells share common epitope specificity but exhibit distinct T cell repertoire.
Q47095275IL-17A-Producing Foxp3+ Regulatory T Cells and Human Diseases
Q33968156IL-1β promotes TGF-β1 and IL-2 dependent Foxp3 expression in regulatory T cells.
Q36200557IL-7 uniquely maintains FoxP3(+) adaptive Treg cells that reverse diabetes in NOD mice via integrin-β7-dependent localization
Q37641059Immune infiltration in human tumors: a prognostic factor that should not be ignored
Q34750481Immunomodulatory effects of transforming growth factor-β in the liver
Q38194133Improving engraftment and immune reconstitution in umbilical cord blood transplantation
Q47140596In Vivo Attenuation of Antibody-Mediated Acute Renal Allograft Rejection by Ex Vivo TGF-β-Induced CD4+Foxp3+ Regulatory T Cells
Q36537036In vivo activation of transferred regulatory T cells specific for third-party exogenous antigen controls GVH disease in mice
Q36378864Induced Foxp3(+) regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases?
Q35050808Interferon-gamma producing regulatory T cells as a diagnostic and therapeutic tool in organ transplantation
Q33999367Isolation of purified and live Foxp3+ regulatory T cells using FACS sorting on scatter plot
Q61802512Kidney Transplant Outcome Is Associated with Regulatory T Cell Population and Gene Expression Early after Transplantation
Q34661115Lineage stability and phenotypic plasticity of Foxp3⁺ regulatory T cells.
Q36551599Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity
Q92319311Mechanisms of human FoxP3+ Treg cell development and function in health and disease
Q42117528Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
Q41696924Mild hypothermia provides Treg stability.
Q39380502Molecular mechanisms underlying Th1-like Treg generation and function.
Q37952092Molecular mechanisms underlying the regulation and functional plasticity of FOXP3(+) regulatory T cells
Q37881151Moving to tolerance: clinical application of T regulatory cells
Q42046573New tools to expand regulatory T cells from HIV-1-infected individuals.
Q90197782Next-generation regulatory T cell therapy
Q46975760Novel Concept of CD4-Mediated Activation of Regulatory T Cells for the Treatment of Graft-Versus-Host Disease.
Q38367524Now or never? The case for cell-based immunosuppression in kidney transplantation.
Q35891619Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion
Q33561651Once a Treg, always a Treg?
Q38790694Optimization of cGMP purification and expansion of umbilical cord blood-derived T-regulatory cells in support of first-in-human clinical trials
Q28081922Origin and functions of pro-inflammatory cytokine producing Foxp3+ regulatory T cells
Q50594543Origin of Enriched Regulatory T Cells in Patients Receiving Combined Kidney-Bone Marrow Transplantation to Induce Transplantation Tolerance.
Q40555716Overexpression of CD45RA isoforms in carriers of the C77G mutation leads to hyporeactivity of CD4+CD25highFoxp3+ regulatory T cells
Q41140315PKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells
Q50130381Partial CD25 Antagonism Enables Dominance of Antigen-Inducible CD25high FOXP3+ Regulatory T Cells As a Basis for a Regulatory T Cell-Based Adoptive Immunotherapy.
Q92286626Peptidase inhibitor 16 identifies a human regulatory T-cell subset with reduced FOXP3 expression over the first year of recent onset type 1 diabetes
Q46584678Phenotypic analysis of human peripheral blood regulatory T cells (CD4+FOXP3+CD127lo/-) ex vivo and after in vitro restimulation with malaria antigens
Q34969823Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.
Q85185759Polyclonal Expansion of Human CD4+CD25+ Regulatory T Cells
Q38235166Potential and limitations of regulatory T-cell therapy in solid organ transplantation.
Q46088131Predominance of activated, clonally expanded T helper type 17 cells within the CD4+ T cell population in psoriatic lesions
Q38097917Promoting transplantation tolerance; adoptive regulatory T cell therapy
Q26800184Regulatory T Cells in Kidney Transplantation: New Directions?
Q47195561Regulatory T Cells: From Discovery to Autoimmunity
Q26784460Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation
Q37900645Regulatory T cells and IL-17-producing cells in graft-versus-host disease
Q89171054Regulatory T cells in autoimmune disease
Q38020963Regulatory T cells in the central nervous system
Q37021703Regulatory T cells vs Th17: differentiation of Th17 versus Treg, are the mutually exclusive?
Q38557841Regulatory T cells: tolerance induction in solid organ transplantation
Q30425184Regulatory T-Cell (Treg) hybridoma as a novel tool to study Foxp3 regulation and Treg fate
Q37309438Regulatory T-Cell Therapy for Graft-versus-host Disease
Q37855952Regulatory T-cell adoptive immunotherapy: potential for treatment of autoimmunity
Q27025869Regulatory T-cell therapy in transplantation: moving to the clinic
Q58694412Regulatory immunotherapy in bone marrow transplantation
Q35242154Resolving the identity myth: key markers of functional CD4+FoxP3+ regulatory T cells.
Q38963375Restoring Regulatory T Cells in Type 1 Diabetes
Q93347701Restoring self-tolerance in autoimmune diseases by enhancing regulatory T-cells
Q37550184Soluble OX40L and JAG1 Induce Selective Proliferation of Functional Regulatory T-Cells Independent of canonical TCR signaling
Q35193745Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells
Q38644779Stabilizing human regulatory T cells for tolerance inducing immunotherapy
Q38918455Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation.
Q56447647Systemic lupus erythematosus exhibits a dynamic and continuum spectrum of effector/regulatory T cells
Q39575774T cell signaling targets for enhancing regulatory or effector function
Q41939919T cell-intrinsic TLR2 stimulation promotes IL-10 expression and suppressive activity by CD45RbHi T cells
Q37792312T regulatory cells and the control of alloimmunity: from characterisation to clinical application
Q43044049TGF-β-induced CD4+Foxp3+ T cells attenuate acute graft-versus-host disease by suppressing expansion and killing of effector CD8+ cells.
Q37595721Targeting Treg cells in situ: emerging expansion strategies for (CD4(+)CD25(+)) regulatory T cells
Q46184995Targeting the epitope spreader Pep19 by naïve human CD45RA+ regulatory T cells dictates a distinct suppressive T cell fate in a novel form of immunotherapy.
Q36075960The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway.
Q35928046The molecular mechanisms of regulatory T cell immunosuppression
Q37528094The plasticity of human Treg and Th17 cells and its role in autoimmunity
Q37861024The prognostic impact of anti-cancer immune response: a novel classification of cancer patients
Q36085059The role of all-trans retinoic acid in the biology of Foxp3+ regulatory T cells
Q47623651The role of regulatory T cells in the regulation of upper airway inflammation
Q51014475The time is crucial for ex vivo expansion of T regulatory cells for therapy.
Q28118511The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3
Q52674851Therapeutic Potential of Gene-Modified Regulatory T Cells: From Bench to Bedside.
Q46772183Therapeutic application of T regulatory cells in composite tissue allotransplantation.
Q34527281Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer
Q37616428Therapeutic polyclonal human CD8+ CD25+ Fox3+ TNFR2+ PD-L1+ regulatory cells induced ex-vivo
Q38000048Therapeutic potential of induced and natural FoxP3(+) regulatory T cells for the treatment of Graft-versus-host disease
Q58615311Tolerising cellular therapies: what is their promise for autoimmune disease?
Q39175303Transplant genetics and genomics
Q27008946Treg functional stability and its responsiveness to the microenvironment
Q34957397Treg vaccination in autoimmune type 1 diabetes
Q39836444Tregs activated by bispecific antibodies: Killers or suppressors?
Q36456483Trial watch: Prognostic and predictive value of the immune infiltrate in cancer
Q36043724Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.