Calphostin C induces AP1 synthesis and AP1-dependent c-jun transactivation in normal human chondrocytes independent of protein kinase C-alpha inhibition: possible role for c-jun N-terminal kinase.

scientific article published in December 1999

Calphostin C induces AP1 synthesis and AP1-dependent c-jun transactivation in normal human chondrocytes independent of protein kinase C-alpha inhibition: possible role for c-jun N-terminal kinase. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/(SICI)1097-4644(20000201)76:2<290::AID-JCB12>3.0.CO;2-V
P698PubMed publication ID10618645

P50authorJohanne Martel-PelletierQ1697061
P2093author name stringC Miller
M Zhang
Y He
J P Pelletier
J A Di Battista
P2860cites workThe cyclic AMP response element plays an essential role in the expression of the human prostaglandin-endoperoxide synthase 2 gene in differentiated U937 monocytic cellsQ72134277
Protein kinase C: interactions and consequencesQ75293231
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factorQ28288345
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1Q28291340
c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactionsQ28298557
Transcription factor ATF2 regulation by the JNK signal transduction pathwayQ28305631
How MAP kinases are regulatedQ28609360
Protein kinase C: structure, function, and regulationQ28618608
Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase CQ29620247
The regulation of AP-1 activity by mitogen-activated protein kinasesQ29620431
Different binding specificities and transactivation of variant CRE's by CREB complexesQ34822878
A three-dimensional collagen lattice induces protein kinase C-zeta activity: role in alpha2 integrin and collagenase mRNA expressionQ36259429
The regulation of transcription by phosphorylationQ36377421
DNA binding activities of three murine Jun proteins: stimulation by Fos.Q36434190
Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytesQ36819033
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activityQ38336655
Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear proteinQ38338602
Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C.Q38345137
Interleukin-1beta activates protein kinase C zeta in renal mesangial cells. Potential role in prostaglandin E2 up-regulationQ38355205
Fos and Jun: the AP-1 connectionQ39606540
The protein kinase C and protein kinase C related gene families.Q40428353
Apoptosis of human glioma cells in response to calphostin C, a specific protein kinase C inhibitorQ41268780
c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK.Q41442860
Light-dependent induction of early-response gene expression by calphostin-C.Q41452947
JNK is involved in signal integration during costimulation of T lymphocytes.Q41461688
Inhibition by cAMP of Ras-Dependent Activation of RafQ41514458
Inhibition of protein kinase C by calphostin C is light-dependentQ41687741
v-src induces prostaglandin synthase 2 gene expression by activation of the c-Jun N-terminal kinase and the c-Jun transcription factorQ42820538
Overexpression of cellular activity and protein level of protein kinase FA/GSK‐3α correlates with human thyroid tumor cell dedifferentiationQ45056089
Glucocorticoid receptor mediated inhibition of interleukin-1 stimulated neutral metalloprotease synthesis in normal human chondrocytesQ67912741
Modulation of interleukin-1–induced alterations in cartilage proteoglycan metabolism by activation of protein kinase CQ67925053
Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase CQ69059319
Protein kinase C activator inhibits progression of osteoarthritis induced in rabbit knee jointsQ71120894
Calphostin C induces tyrosine dephosphorylation/inactivation of protein kinase FA/GSK-3 alpha in a pathway independent of tumor promoter phorbol ester-mediated down-regulation of protein kinase CQ71576395
Prostaglandin E2 up-regulates insulin-like growth factor binding protein-3 expression and synthesis in human articular chondrocytes by a c-AMP-independent pathway: role of calcium and protein kinase A and CQ71769552
P433issue2
P304page(s)290-302
P577publication date1999-12-01
P1433published inJournal of Cellular BiochemistryQ6294917
P1476titleCalphostin C induces AP1 synthesis and AP1-dependent c-jun transactivation in normal human chondrocytes independent of protein kinase C-alpha inhibition: possible role for c-jun N-terminal kinase.
P478volume76

Reverse relations

cites work (P2860)
Q54472600Dextromethorphan attenuates LPS-induced adhesion molecule expression in human endothelial cells.
Q37101667Forebrain ischemia-reperfusion simulating cardiac arrest in mice induces edema and DNA fragmentation in the brain
Q36539539Identification and characterization of Chlamydia pneumoniae-specific proteins that activate tumor necrosis factor alpha production in RAW 264.7 murine macrophages
Q22255498Imaging Cerebral Gene Transcripts in Live Animals
Q38302094MR contrast probes that trace gene transcripts for cerebral ischemia in live animals
Q35214667Signaling to migration in neutrophils: importance of localized pathways

Search more.