Abstract is: Dr. David D. Ginty (born 1962) is an American neuroscientist and developmental biologist. David graduated from Mount Saint Mary's College and received his Ph.D. degree in physiology from East Carolina University for graduate work with Edward Seidel, on the regulation of polyamine compounds and their metabolism during cell growth and proliferation. Moving to Boston, David completed his postdoctoral research, first, with John Wagner at the Dana–Farber Cancer Institute at Harvard Medical School, and then with Michael Greenberg at Harvard Medical School, where he made several seminal contributions to signal transduction and growth factor signaling in neurons. In 1995, David was invited by Solomon Snyder to move to Baltimore, Maryland, to become a new faculty member of the Department of Neuroscience at the Johns Hopkins University School of Medicine. In 2000, he became an investigator of the Howard Hughes Medical Institute. David remained a faculty member at Johns Hopkins for 18 years. In the fall of 2013, David and his laboratory moved from Maryland to Boston, MA, where he became the Edward R. and Anne G. Lefler Professor of Neurobiology in the Department of Neurobiology at Harvard Medical School, while maintaining his status of an HHMI investigator. In the 1990s, David received several awards including a , a Award, and the Basil O'Connor Starter Scholar Award from the March of Dimes. After becoming established, he received a Jacob Javitz Neuroscience Investigator's Award from the National Institutes of Health. In 2015, David was elected into the American Academy of Arts and Science. In 2017, David was elected to the National Academy of Sciences. His lab at Johns Hopkins discovered functions and mechanisms of action of neuronal growth factors and axon guidance cues, and mechanisms of assembly and functional organization of the neural circuits that underlie autonomic functions and the sense of touch. His lab at Harvard uses a variety of techniques including genetics, circuit mapping, and electrophysiological analyses to gain understanding of the development, organization, and function of neural circuits that underlie the sense of touch. He uses mouse molecular genetic approaches to identify, visualize, and functionally manipulate physiologically defined classes of low-threshold mechanosensory neurons (LTMRs), the primary cutaneous sensory neurons that mediate the sense of touch, as well as spinal cord neurons that process LTMR information and convey it to the brain.
human | Q5 |
P2381 | Academic Tree ID | 4329 |
P646 | Freebase ID | /m/03c_4pz |
P244 | Library of Congress authority ID | n2012189655 |
no2017023296 | ||
P5380 | National Academy of Sciences member ID | 20041812 |
P496 | ORCID iD | 0000-0001-9723-8530 |
P4012 | Semantic Scholar author ID | 6965353 |
P214 | VIAF ID | 287385692 |
7148874519849621155 |
P166 | award received | Fellow of the American Association for the Advancement of Science | Q5442484 |
P27 | country of citizenship | United States of America | Q30 |
P69 | educated at | East Carolina University | Q1277776 |
Mount St. Mary's University | Q6923804 | ||
P108 | employer | Harvard Medical School | Q49121 |
Johns Hopkins University | Q193727 | ||
Howard Hughes Medical Institute | Q1512226 | ||
P734 | family name | Ginty | Q21492208 |
Ginty | Q21492208 | ||
Ginty | Q21492208 | ||
P735 | given name | David | Q18057751 |
David | Q18057751 | ||
P463 | member of | National Academy of Sciences | Q270794 |
P106 | occupation | researcher | Q1650915 |
neuroscientist | Q6337803 | ||
P551 | residence | Maryland | Q1391 |
P21 | sex or gender | male | Q6581097 |
Q46429990 | A chemical-genetic approach to studying neurotrophin signaling |
Q33849150 | A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal |
Q28505880 | A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons |
Q36728766 | A model for neuronal competition during development |
Q52088593 | A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. |
Q28510057 | A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons |
Q52097674 | Active Touch and Self-Motion Encoding by Merkel Cell-Associated Afferents. |
Q28584964 | An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates |
Q28505126 | Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB |
Q33594808 | Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex |
Q36505916 | Calcium signals control Wnt-dependent dendrite growth |
Q34358632 | Differential requirements for semaphorin 3F and Slit-1 in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections. |
Q34477943 | Distinct roles for secreted semaphorin signaling in spinal motor axon guidance |
Q28593913 | Dystroglycan organizes axon guidance cue localization and axonal pathfinding |
Q37269587 | Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons |
Q52551292 | Evidence in support of signaling endosome-based retrograde survival of sympathetic neurons. |
Q36311690 | Extrinsic and intrinsic signals converge on the Runx1/CBFβ transcription factor for nonpeptidergic nociceptor maturation |
Q36215528 | Functions and mechanisms of retrograde neurotrophin signalling |
Q41844696 | Genetic Identification of an Expansive Mechanoreceptor Sensitive to Skin Stroking |
Q36196524 | Growth and survival signals controlling sympathetic nervous system development |
Q28587439 | Heterogeneous requirement of NGF for sympathetic target innervation in vivo |
Q28594886 | LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development |
Q33876935 | Linx mediates interaxonal interactions and formation of the internal capsule |
Q34171908 | Long-distance control of synapse assembly by target-derived NGF. |
Q34328577 | Long-distance retrograde neurotrophic factor signalling in neurons |
Q21128782 | MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons |
Q96590198 | Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception |
Q28580488 | Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival |
Q33619112 | Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling |
Q28508306 | Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development |
Q92461490 | Multiplexed peroxidase-based electron microscopy labeling enables simultaneous visualization of multiple cell types |
Q48142730 | Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling. |
Q28585676 | Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development |
Q48654388 | Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons. |
Q101051370 | Parallel ascending spinal pathways for affective touch and pain |
Q41493945 | Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs |
Q40487239 | Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins |
Q40534480 | Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival |
Q28512435 | Restricted inactivation of serum response factor to the cardiovascular system |
Q40190102 | Retrograde control of neural circuit formation |
Q34671401 | Retrograde neurotrophin signaling: Trk-ing along the axon |
Q41460503 | Retrogradely Transported TrkA Endosomes Signal Locally within Dendrites to Maintain Sympathetic Neuron Synapses |
Q34413584 | SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells |
Q42477944 | SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability |
Q28584955 | Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure |
Q33742592 | Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS. |
Q46425957 | Secreted semaphorins modulate synaptic transmission in the adult hippocampus. |
Q34989752 | Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting |
Q47724321 | Semaphorin 3F is critical for development of limbic system circuitry and is required in neurons for selective CNS axon guidance events. |
Q37209812 | Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons |
Q37304060 | Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland |
Q35099606 | Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance |
Q30365130 | The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. |
Q33671912 | The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value |
Q27323935 | The cellular and molecular basis of direction selectivity of Aδ-LTMRs |
Q115683384 | The encoding of touch by somatotopically aligned dorsal column subdivisions |
Q40534410 | The functional organization of cutaneous low-threshold mechanosensory neurons |
Q38270142 | The gentle touch receptors of mammalian skin |
Q37596041 | The structure and organization of lanceolate mechanosensory complexes at mouse hair follicles |
Q41500862 | Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses |
Q37621018 | Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve |
Q43971437 | What a privilege to reside at the synapse: NMDA receptor signaling to CREB. |
Egyptian Arabic (arz / Q29919) | ديفيد دى جينتى | wikipedia |
David Ginty | wikipedia |
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