An Essential Role for ECSIT in Mitochondrial Complex I Assembly and Mitophagy in Macrophages.

scientific article published in March 2018

An Essential Role for ECSIT in Mitochondrial Complex I Assembly and Mitophagy in Macrophages. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CELREP.2018.02.051
P932PMC publication ID5909989
P698PubMed publication ID29514094

P50authorAlice LepelleyQ56871875
Flávia R G CarneiroQ84113506
P2093author name stringSankar Ghosh
Matthew S Hayden
John J Seeley
P2860cites workPINK1 is selectively stabilized on impaired mitochondria to activate ParkinQ21145802
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathwayQ22010492
Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex IQ24298522
Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assemblyQ24299292
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stabilityQ24299939
Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathyQ24302105
YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferationQ24302280
TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complexQ24314040
Parkin is recruited selectively to impaired mitochondria and promotes their autophagyQ24317471
The pathways of mitophagy for quality control and clearance of mitochondriaQ27009206
Self and nonself: how autophagy targets mitochondria and bacteriaQ27012602
Architecture of succinate dehydrogenase and reactive oxygen species generationQ27640410
Ubiquitin-dependent mitochondrial protein degradationQ27692704
The YTA10-12 complex, an AAA protease with chaperone-like activity in the inner membrane of mitochondriaQ27931009
Isolated complex I deficiency in children: clinical, biochemical and genetic aspectsQ28143420
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseasesQ28269333
Mitochondria and reactive oxygen species: physiology and pathophysiologyQ28397259
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesisQ28587816
Intestinal epithelial autophagy is essential for host defense against invasive bacteriaQ30543790
Respiratory chain complex I deficiency: an underdiagnosed energy generation disorderQ33600939
Oxidative stress and mitochondrial dysfunction across broad-ranging pathologies: toward mitochondria-targeted clinical strategiesQ33625254
Low abundance of the matrix arm of complex I in mitochondria predicts longevity in miceQ33626717
A hyperactive piggyBac transposase for mammalian applicationsQ33785567
Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS releaseQ33913079
High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria.Q34014350
Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarizationQ34143332
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.Q34180844
A giant molecular proton pump: structure and mechanism of respiratory complex I.Q34477041
Mitochondrial ROS metabolism: modulation by uncoupling proteins.Q34499078
Mutations in human nuclear genes encoding for subunits of mitochondrial respiratory complex I: the NDUFS4 geneQ34594206
Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradationQ35163362
An update on complex I assembly: the assembly of playersQ35547747
Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activityQ36200269
Natural disease course and genotype-phenotype correlations in Complex I deficiency caused by nuclear gene defects: what we learned from 130 cases.Q36203487
Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.Q37197479
Biallelic Mutations in TMEM126B Cause Severe Complex I Deficiency with a Variable Clinical PhenotypeQ37218530
Assembly factors for the membrane arm of human complex I.Q37340668
Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutaseQ37357532
The ubiquitin ligase parkin mediates resistance to intracellular pathogensQ37458253
Assembly factors of human mitochondrial complex I and their defects in diseaseQ37765531
Ubiquitin-proteasome system and mitochondria - reciprocityQ37776909
Understanding mitochondrial complex I assembly in health and diseaseQ37933572
The role of mitochondrial OXPHOS dysfunction in the development of neurologic diseasesQ37994541
The Assembly Pathway of Mitochondrial Respiratory Chain Complex I.Q38741912
A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria.Q39675106
Mutations in the mitochondrial complex I assembly factor NDUFAF1 cause fatal infantile hypertrophic cardiomyopathyQ39706072
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membraneQ42235376
Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages.Q42248604
The contribution of mitochondrial respiratory complexes to the production of reactive oxygen species.Q42514984
A case of mitochondrial myopathy, lactic acidosis and complex I deficiencyQ43635325
Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase.Q45050762
Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.Q45050765
ELMO1 regulates the induction of autophagy and bacterial clearance during enteric infection.Q46252758
Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK/T cell lymphomaQ47240802
NDUFAF4 variants are associated with Leigh syndrome and cause a specific mitochondrial complex I assembly defectQ47788849
Loss of cytochrome c oxidase promotes RAS-dependent ROS production from the ER resident NADPH oxidase, Yno1p, in yeastQ47818025
Fatal mitochondrial myopathy, lactic acidosis, and complex I deficiency associated with a heteroplasmic A --> G mutation at position 3251 in the mitochondrial tRNALeu(UUR) gne.Q49082669
Complexome profiling identifies TMEM126B as a component of the mitochondrial complex I assembly complex.Q50241308
Afg3p, a mitochondrial ATP-dependent metalloprotease, is involved in degradation of mitochondrially-encoded Cox1, Cox3, Cob, Su6, Su8 and Su9 subunits of the inner membrane complexes III, IV and VQ71103986
P433issue10
P304page(s)2654-2666
P577publication date2018-03-01
P1433published inCell ReportsQ5058165
P1476titleAn Essential Role for ECSIT in Mitochondrial Complex I Assembly and Mitophagy in Macrophages
P478volume22

Reverse relations

cites work (P2860)
Q91712071A Combined Mass Spectrometry and Data Integration Approach to Predict the Mitochondrial Poly(A) RNA Interacting Proteome
Q91868596Common Neurodegeneration-Associated Proteins Are Physiologically Expressed by Human B Lymphocytes and Are Interconnected via the Inflammation/Autophagy-Related Proteins TRAF6 and SQSTM1
Q91819984Emerging perspectives on mitochondrial dysfunction and inflammation in Alzheimer's disease
Q92153256Metabolic Reprogramming in Mitochondria of Myeloid Cells
Q91814085Metabolic, Anti-apoptotic and Immune Evasion Strategies of Primary Human Myeloma Cells Indicate Adaptations to Hypoxia
Q91231275Mitochondria in innate immune signaling
Q64988558Nilotinib: A Tyrosine Kinase Inhibitor Mediates Resistance to Intracellular Mycobacterium Via Regulating Autophagy.
Q89878907TLR2 Signaling Pathway Combats Streptococcus uberis Infection by Inducing Mitochondrial Reactive Oxygen Species Production
Q92106730The Metabolic Signature of Macrophage Responses

Search more.