Phase I study of the heparanase inhibitor Roneparstat: an innovative approach for multiple myeloma therapy

scientific article published on 26 April 2018

Phase I study of the heparanase inhibitor Roneparstat: an innovative approach for multiple myeloma therapy is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3324/HAEMATOL.2017.182865
P932PMC publication ID6165822
P698PubMed publication ID29700168

P50authorHermann EinseleQ1610986
Giorgina SpecchiaQ38322931
P2093author name stringRalph D Sanderson
Alessandro Rambaldi
Arnon Nagler
Silvia Pace
Hila Magen
Paola Barbieri
Manik Chatterjee
Mariella Grasso
Monica Galli
Ivana Celeghini
David Paoletti
P2860cites workSoluble syndecan-1 promotes growth of myeloma tumors in vivoQ28208004
SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 AxisQ34694466
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myelomaQ36973696
Heparanase as a target in cancer therapy.Q38190997
Targeting the bone marrow microenvironment in multiple myeloma.Q38289041
Targeting heparanase overcomes chemoresistance and diminishes relapse in myelomaQ38815363
Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapyQ38985052
Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase.Q40707545
Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotypeQ41158870
Heparanase: From basic research to therapeutic applications in cancer and inflammationQ42587945
Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splittingQ45221614
High heparanase activity in multiple myeloma is associated with elevated microvessel densityQ75207710
Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasisQ79906000
P433issue10
P407language of work or nameEnglishQ1860
P921main subjecthematologyQ103824
P304page(s)e469-e472
P577publication date2018-04-26
P1433published inHaematologicaQ5638209
P1476titlePhase I study of the heparanase inhibitor Roneparstat: an innovative approach for multiple myeloma therapy
P478volume103

Reverse relations

cites work (P2860)
Q61453558Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4
Q89497261Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan
Q91646567Clinical applications of exosome membrane proteins
Q60960606Established and Emerging Concepts to Treat Imbalances of Iron Homeostasis in Inflammatory Diseases
Q91798106Forty Years of Basic and Translational Heparanase Research
Q99591085Hedgehog Signaling and Truncated GLI1 in Cancer
Q58585910Heparan Sulfate Mimetics in Cancer Therapy: The Challenge to Define Structural Determinants and the Relevance of Targets for Optimal Activity
Q89622368Heparanase Loosens E-Cadherin-Mediated Cell-Cell Contact via Activation of Src
Q60931211Heparanase: A Multitasking Protein Involved in Extracellular Matrix (ECM) Remodeling and Intracellular Events
Q59799492Inhibition of heparanase protects against chronic kidney dysfunction following ischemia/reperfusion injury
Q99713814Long-chain polyunsaturated omega-3 fatty acids reduce multiple myeloma exosome-mediated suppression of NK cell cytotoxicity
Q58761454Multiple Roles of Glycans in Hematological Malignancies
Q92137106Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds
Q92812032The Challenge of Modulating Heparan Sulfate Turnover by Multitarget Heparin Derivatives
Q90288843The multifaceted role of iron in renal health and disease

Search more.