Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors.

scientific article published on 24 April 2018

Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MBIO.00430-18
P932PMC publication ID5915737
P698PubMed publication ID29691337

P50authorRichard WebbyQ89595126
Elena GovorkovaQ89851432
Jeremy C JonesQ90689818
P2093author name stringStephen W White
Gyanendra Kumar
Subrata Barman
Isabel Najera
P2860cites workCrystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active siteQ27653656
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunitQ27653657
Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA EndonucleaseQ27671357
Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) PolymeraseQ27671365
HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutesQ27860502
The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug DesignQ28071809
Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonucleaseQ28534627
Phaser.MRage: automated molecular replacementQ28661765
A Novel Endonuclease Inhibitor Exhibits Broad-Spectrum Anti-Influenza Virus Activity In VitroQ30390167
Antivirals for pandemic influenzaQ30427953
Characterization of mutants of influenza A virus selected with the neuraminidase inhibitor 4-guanidino-Neu5Ac2enQ35857200
Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor.Q36770792
Oseltamivir-resistant influenza virus A (H1N1), Europe, 2007-08 seasonQ37164761
In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses.Q37392896
Single PA mutation as a high yield determinant of avian influenza vaccinesQ37584477
The PA Endonuclease Inhibitor RO-7 Protects Mice from Lethal Challenge with Influenza A or B VirusesQ38963385
PA subunit of RNA polymerase as a promising target for anti-influenza virus agentsQ40015466
Selection of multi-drug resistant influenza A and B viruses under zanamivir pressure and their replication fitness in ferrets.Q40333849
Eight-plasmid system for rapid generation of influenza virus vaccinesQ40712787
In vitro selection and characterisation of influenza B/Beijing/1/87 isolates with altered susceptibility to zanamivirQ40911739
Mutational and metal binding analysis of the endonuclease domain of the influenza virus polymerase PA subunitQ42428242
Infections with oseltamivir-resistant influenza A(H1N1) virus in the United StatesQ45118572
In vivo Selection of an Influenza A2 Strain resistant to AmantadineQ71478276
P2507corrigendum / erratumAuthor Correction for Jones et al., "Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors"Q59132664
P433issue2
P577publication date2018-04-24
P1433published inmBioQ15817061
P1476titleIdentification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors.
P478volume9

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cites work (P2860)
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Q64136457A Step Forward in the Treatment of Influenza
Q93028017Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference
Q90689822Influenza A and B viruses with reduced baloxavir susceptibility display attenuated in vitro fitness but retain ferret transmissibility
Q63976719Influenza virus polymerase inhibitors in clinical development
Q64065291Inhibition of avian-origin influenza A(H7N9) virus by the novel cap-dependent endonuclease inhibitor baloxavir marboxil
Q90736243Key Role of the Influenza A Virus PA Gene Segment in the Emergence of Pandemic Viruses
Q89843860Next-generation direct-acting influenza therapeutics
Q66679577Overview of Current Therapeutics and Novel Candidates Against Influenza, Respiratory Syncytial Virus, and Middle East Respiratory Syndrome Coronavirus Infections
Q60046097Susceptibility of Influenza Viruses to the Novel Cap-Dependent Endonuclease Inhibitor Baloxavir Marboxil

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