Targeting EGFR/HER2/HER3 with a Three-in-One Aptamer-siRNA Chimera Confers Superior Activity against HER2+ Breast Cancer.

scientific article published on 30 December 2017

Targeting EGFR/HER2/HER3 with a Three-in-One Aptamer-siRNA Chimera Confers Superior Activity against HER2+ Breast Cancer. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.OMTN.2017.12.015
P932PMC publication ID5862534
P698PubMed publication ID29499944

P50authorHasan KorkayaQ62592865
P2093author name stringLu Xue
Xiaolin Yu
Haitao Liu
Lijing Zhao
Daqing Wu
Shou-Ching Tang
Nita J Maihle
Sharad Ghamande
Shuhua Zhao
Hong Yan Liu
Wenxi Tan
P2860cites workPan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and PlasticityQ38882857
Four-in-one antibodies have superior cancer inhibitory activity against EGFR, HER2, HER3, and VEGF through disruption of HER/MET crosstalk.Q38942597
PEGylated anti-MUC1 aptamer-doxorubicin complex for targeted drug delivery to MCF7 breast cancer cellsQ39494655
EGFR over-expression and activation in high HER2, ER negative breast cancer cell line induces trastuzumab resistanceQ39783093
Trastuzumab-induced HER reprogramming in "resistant" breast carcinoma cellsQ39874639
A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapyQ39960692
Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family membersQ40009294
Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor networkQ40093663
Interferon induction by siRNAs and ssRNAs synthesized by phage polymeraseQ40584437
Expression of the HER1-4 family of receptor tyrosine kinases in breast cancerQ44503047
Absence of HER4 expression predicts recurrence of ductal carcinoma in situ of the breastQ46402523
Aptamers as therapeutics.Q51813594
PEGylation and biodistribution of an anti-MUC1 aptamer in MCF-7 tumor-bearing miceQ84398421
The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferationQ24678674
Outcome and human epidermal growth factor receptor (HER) 1-4 status in invasive breast carcinomas with proliferation indices evaluated by bromodeoxyuridine labellingQ24794988
Bispecific antibodiesQ27027186
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
In vitro selection of RNA molecules that bind specific ligandsQ27861109
Progress toward in vivo use of siRNAs-IIQ28255877
Structural basis for overhang-specific small interfering RNA recognition by the PAZ domainQ28262499
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancerQ29617440
The ErbB signaling network: receptor heterodimerization in development and cancerQ29617919
Simultaneous targeting of CD44 and EpCAM with a bispecific aptamer effectively inhibits intraperitoneal ovarian cancer growthQ33588273
ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeuticsQ33601653
Aptamer-targeted antigen deliveryQ33870736
In vitro selection of RNA aptamer and specific targeting of ErbB2 in breast cancer cellsQ33958666
Complement-targeted therapeuticsQ34255011
EGFR and cancer prognosisQ34399312
Trastuzumab: a review of its use in the treatment of metastatic breast cancer overexpressing HER2.Q34492647
Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimerasQ35015737
An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized miceQ35111705
Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3.Q35234347
High throughput sequencing analysis of RNA libraries reveals the influences of initial library and PCR methods on SELEX efficiency.Q36139325
Identification and characterization of an agonistic aptamer against the T cell costimulatory receptor, OX40.Q36603032
c-erbB-4 protein expression in human breast cancerQ36621288
Trastuzumab: triumphs and tribulationsQ36832109
Co-targeting EGFR and survivin with a bivalent aptamer-dual siRNA chimera effectively suppresses prostate cancerQ37125328
Chemical modification of siRNAs for in vivo use.Q37331765
Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors.Q37469987
Therapeutic RNA aptamers in clinical trialsQ38059064
Aptamers as targeted therapeutics: current potential and challengesQ38290290
Targeting the HER Family with Pan-HER Effectively Overcomes Resistance to CetuximabQ38757863
HER3 Targeting Sensitizes HNSCC to Cetuximab by Reducing HER3 Activity and HER2/HER3 Dimerization: Evidence from Cell Line and Patient-Derived Xenograft ModelsQ38760738
A Potent HER3 Monoclonal Antibody That Blocks Both Ligand-Dependent and -Independent Activities: Differential Impacts of PTEN Status on Tumor ResponseQ38793980
Antitumor Effects of MEHD7945A, a Dual-Specific Antibody against EGFR and HER3, in Combination with Radiation in Lung and Head and Neck CancersQ38856785
P304page(s)317-330
P577publication date2017-12-30
P1433published inMolecular Therapy. Nucleic acidsQ27724110
P1476titleTargeting EGFR/HER2/HER3 with a Three-in-One Aptamer-siRNA Chimera Confers Superior Activity against HER2+ Breast Cancer
P478volume10

Reverse relations

cites work (P2860)
Q89791186A novel anti-HER2 antibody GB235 reverses Trastuzumab resistance in HER2-expressing tumor cells in vitro and in vivo
Q58584175Aptamer Chimeras for Therapeutic Delivery: The Challenging Perspectives
Q57812842Aptamer-iRNAs as Therapeutics for Cancer Treatment
Q92327243Aptamers as Delivery Agents of siRNA and Chimeric Formulations for the Treatment of Cancer
Q97568985Design, fabrication and applications of tetrahedral DNA nanostructure-based multifunctional complexes in drug delivery and biomedical treatment
Q90291164Elimination of HER3-expressing breast cancer cells using aptamer-siRNA chimeras
Q92406179Lipid Profile and Aquaporin Expression under Oxidative Stress in Breast Cancer Cells of Different Malignancies
Q90316294MiR-519d targets HER3 and can be used as a potential serum biomarker for non-small cell lung cancer
Q58728275Synergistic Targeting HER2 and EGFR with Bivalent Aptamer-siRNA Chimera Efficiently Inhibits HER2-Positive Tumor Growth

Search more.